ID:RASF1_HUMAN DESCRIPTION: RecName: Full=Ras association domain-containing protein 1; FUNCTION: Potential tumor suppressor. Required for death receptor- dependent apoptosis. Mediates activation of STK3/MST2 and STK4/MST1 during Fas-induced apoptosis by preventing their dephosphorylation. When associated with MOAP1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. Isoform A interacts with CDC20, an activator of the anaphase-promoting complex, APC, resulting in the inhibition of APC activity and mitotic progression. Inhibits proliferation by negatively regulating cell cycle progression at the level of G1/S-phase transition by regulating accumulation of cyclin D1 protein. Isoform C has been shown not to perform these roles, no function has been identified for this isoform. Isoform A disrupts interactions among MDM2, DAXX and USP7, thus contributing to the efficient activation of TP53 by promoting MDM2 self-ubiquitination in cell-cycle checkpoint control in response to DNA damage. SUBUNIT: Interacts with MAP1S and XPA. Binds to the N-terminal of CDC20 during prometaphase. Binds to STK3/MST2 and STK4/MST1. Isoform A interacts with MOAP1 and E4F1. Recruited to the TNFRSF1A and TNFRSF10A complexes in response to their respective cognate ligand, after internalization. Can self-associate. Isoform A interacts with RSSF5 and probably associates with HRAS1 via a RSSF1 isoform A-RSSF5 heterodimer. Part of a complex with MDM2, DAXX, RASSF1 and USP7. Isoform A interacts (via C-terminus) with DAXX (via N-terminus); the interaction is independent of MDM2 and TP53. Isoform C or isoform H interacts (via N-terminus) with DAXX. Isoform A interacts (via N-terminus) with MDM2 (via C-terminus); the interaction is independent of TP53. INTERACTION: Q12834:CDC20; NbExp=2; IntAct=EBI-438698, EBI-367462; Q66K89:E4F1; NbExp=7; IntAct=EBI-438698, EBI-1227043; Q01844:EWSR1; NbExp=3; IntAct=EBI-438698, EBI-739737; O95166:GABARAP; NbExp=2; IntAct=EBI-367363, EBI-712001; P60520:GABARAPL2; NbExp=2; IntAct=EBI-367363, EBI-720116; P01112:HRAS; NbExp=2; IntAct=EBI-438698, EBI-350145; Q9GZQ8:MAP1LC3B; NbExp=2; IntAct=EBI-367363, EBI-373144; Q9BXW4:MAP1LC3C; NbExp=2; IntAct=EBI-367363, EBI-2603996; Q13188:STK3; NbExp=3; IntAct=EBI-438698, EBI-992580; Q13043:STK4; NbExp=4; IntAct=EBI-438698, EBI-367376; SUBCELLULAR LOCATION: Isoform A: Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, centrosome. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Nucleus. Note=Localizes to cytoplasmic microtubules during interphase, to bipolar centrosomes associated with microtubules during prophase, to spindle fibers and spindle poles at metaphase and anaphase, to the midzone during early telophase, and to the midbody in late telophase in cells. Colocalizes with MDM2 in the nucleus. SUBCELLULAR LOCATION: Isoform C: Nucleus. Note=Predominantly nuclear. TISSUE SPECIFICITY: Isoform A and isoform C are ubiquitously expressed in all tissues tested, however isoform A is absent in many corresponding cancer cell lines. Isoform B is mainly expressed in hematopoietic cells. SIMILARITY: Contains 1 phorbol-ester/DAG-type zinc finger. SIMILARITY: Contains 1 Ras-associating domain. SIMILARITY: Contains 1 SARAH domain. SEQUENCE CAUTION: Sequence=AAB67312.1; Type=Erroneous gene model prediction; WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/RASSF1ID377.html";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9NS23
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006974 cellular response to DNA damage stimulus GO:0007049 cell cycle GO:0007050 cell cycle arrest GO:0007165 signal transduction GO:0007265 Ras protein signal transduction GO:0031398 positive regulation of protein ubiquitination GO:0035556 intracellular signal transduction GO:0050821 protein stabilization GO:0070507 regulation of microtubule cytoskeleton organization GO:0071157 negative regulation of cell cycle arrest
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
