ID:RASF2_HUMAN DESCRIPTION: RecName: Full=Ras association domain-containing protein 2; FUNCTION: Potential tumor suppressor. Acts as a KRAS-specific effector protein. May promote apoptosis and cell cycle arrest. Stabilizes STK3/MST2 by protecting it from proteasomal degradation. SUBUNIT: Interacts directly with activated KRAS in a GTP-dependent manner. Interacts (via SARAH domain) with STK3/MST2 AND STK4/MST1. INTERACTION: P01116:KRAS; NbExp=2; IntAct=EBI-960081, EBI-367415; Q13043:STK4; NbExp=4; IntAct=EBI-960081, EBI-367376; SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Translocates to the cytoplasm in the presence of STK3/MST2 AND STK4/MST1. TISSUE SPECIFICITY: Widely expressed with highest levels in brain, placenta, peripheral blood and lung. Frequently down-regulated in lung tumor cell lines. PTM: Phosphorylated by STK3/MST2 and STK4/MST1. SIMILARITY: Contains 1 Ras-associating domain. SIMILARITY: Contains 1 SARAH domain. SEQUENCE CAUTION: Sequence=BAA11485.2; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P50749
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0004672 protein kinase activity GO:0005515 protein binding
Biological Process: GO:0001501 skeletal system development GO:0001503 ossification GO:0006468 protein phosphorylation GO:0007049 cell cycle GO:0007165 signal transduction GO:0031954 positive regulation of protein autophosphorylation GO:0033137 negative regulation of peptidyl-serine phosphorylation GO:0038168 epidermal growth factor receptor signaling pathway via I-kappaB kinase/NF-kappaB cascade GO:0042981 regulation of apoptotic process GO:0043065 positive regulation of apoptotic process GO:0045667 regulation of osteoblast differentiation GO:0045670 regulation of osteoclast differentiation GO:0045860 positive regulation of protein kinase activity GO:0046330 positive regulation of JNK cascade GO:0046849 bone remodeling GO:0048872 homeostasis of number of cells GO:0050821 protein stabilization GO:1901222 regulation of NIK/NF-kappaB signaling GO:1901223 negative regulation of NIK/NF-kappaB signaling
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
