ID:RBL1_HUMAN DESCRIPTION: RecName: Full=Retinoblastoma-like protein 1; AltName: Full=107 kDa retinoblastoma-associated protein; Short=p107; AltName: Full=pRb1; FUNCTION: Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation. Forms a complex with adenovirus E1A and with SV40 large T antigen. May bind and modulate functionally certain cellular proteins with which T and E1A compete for pocket binding. May act as a tumor suppressor. SUBUNIT: Interacts with SUV420H1, SUV420H2 and USP4 (By similarity). Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle- dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL2. Interacts with AATF. Interacts with KDM5A. Interacts with SV40 and JC virus large T antigens. INTERACTION: Q9BUH8:BEGAIN; NbExp=2; IntAct=EBI-971402, EBI-742722; P11802:CDK4; NbExp=2; IntAct=EBI-971402, EBI-295644; Q13574-2:DGKZ; NbExp=2; IntAct=EBI-971402, EBI-715527; Q14653:IRF3; NbExp=2; IntAct=EBI-971402, EBI-2650369; P24610:Pax3 (xeno); NbExp=3; IntAct=EBI-971402, EBI-1208116; Q923E4:Sirt1 (xeno); NbExp=2; IntAct=EBI-971402, EBI-1802585; SUBCELLULAR LOCATION: Nucleus (Potential). PTM: Exists in both phosphorylated and unphosphorylated forms, and T, but not E1A, binds only to the unphosphorylated form. Cell- cycle arrest properties are inactivated by phosphorylation on Thr- 332, Ser-640, Ser-964 and Ser-975 by CDK4. SIMILARITY: Belongs to the retinoblastoma protein (RB) family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF01857 - Retinoblastoma-associated protein B domain PF01858 - Retinoblastoma-associated protein A domain PF08934 - Rb C-terminal domain PF11934 - Domain of unknown function (DUF3452)
ModBase Predicted Comparative 3D Structure on P28749
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0006325 chromatin organization GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0007049 cell cycle GO:0010629 negative regulation of gene expression GO:0016032 viral process GO:0043550 regulation of lipid kinase activity GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0051726 regulation of cell cycle GO:2000773 negative regulation of cellular senescence
AK308096 - Homo sapiens cDNA, FLJ98044. LF383761 - JP 2014500723-A/191264: Polycomb-Associated Non-Coding RNAs. L14812 - Human retinoblastoma related protein (p107) mRNA, complete cds. AK290380 - Homo sapiens cDNA FLJ76705 complete cds, highly similar to Homo sapiens retinoblastoma-like 1 (p107) (RBL1), transcript variant 1, mRNA. M74547 - H.sapiens retinoblastoma related protein (p107) mRNA, 3' end. AB384850 - Synthetic construct DNA, clone: pF1KB3761, Homo sapiens RBL1 gene for retinoblastoma-like protein 1, complete cds, without stop codon, in Flexi system. BC032247 - Homo sapiens retinoblastoma-like 1 (p107), mRNA (cDNA clone MGC:40006 IMAGE:4521266), complete cds. KJ904546 - Synthetic construct Homo sapiens clone ccsbBroadEn_13940 RBL1-like gene, encodes complete protein. DQ890612 - Synthetic construct clone IMAGE:100003242; FLH169170.01X; RZPDo839H0394D retinoblastoma-like 1 (p107) (RBL1) gene, encodes complete protein. DQ893783 - Synthetic construct Homo sapiens clone IMAGE:100008243; FLH169166.01L; RZPDo839H0393D retinoblastoma-like 1 (p107) (RBL1) gene, encodes complete protein. MA619338 - JP 2018138019-A/191264: Polycomb-Associated Non-Coding RNAs. JD510880 - Sequence 491904 from Patent EP1572962. JD286921 - Sequence 267945 from Patent EP1572962. JD116903 - Sequence 97927 from Patent EP1572962. JD138613 - Sequence 119637 from Patent EP1572962. JD534769 - Sequence 515793 from Patent EP1572962. JD447369 - Sequence 428393 from Patent EP1572962. JD141773 - Sequence 122797 from Patent EP1572962. JD041214 - Sequence 22238 from Patent EP1572962. JD169178 - Sequence 150202 from Patent EP1572962. JD529106 - Sequence 510130 from Patent EP1572962. JD430124 - Sequence 411148 from Patent EP1572962. JD455198 - Sequence 436222 from Patent EP1572962. JD201253 - Sequence 182277 from Patent EP1572962. JD457078 - Sequence 438102 from Patent EP1572962. JD041213 - Sequence 22237 from Patent EP1572962. JD559650 - Sequence 540674 from Patent EP1572962. JD169176 - Sequence 150200 from Patent EP1572962. JD092491 - Sequence 73515 from Patent EP1572962. JD481568 - Sequence 462592 from Patent EP1572962. JD514908 - Sequence 495932 from Patent EP1572962. JD294104 - Sequence 275128 from Patent EP1572962. JD421421 - Sequence 402445 from Patent EP1572962. JD145388 - Sequence 126412 from Patent EP1572962. JD199434 - Sequence 180458 from Patent EP1572962. JD106660 - Sequence 87684 from Patent EP1572962. JD186525 - Sequence 167549 from Patent EP1572962. JD286026 - Sequence 267050 from Patent EP1572962. JD246972 - Sequence 227996 from Patent EP1572962. JD429246 - Sequence 410270 from Patent EP1572962. JD413417 - Sequence 394441 from Patent EP1572962. JD198117 - Sequence 179141 from Patent EP1572962. JD212728 - Sequence 193752 from Patent EP1572962. JD542750 - Sequence 523774 from Patent EP1572962. JD537334 - Sequence 518358 from Patent EP1572962. JD537333 - Sequence 518357 from Patent EP1572962. JD551555 - Sequence 532579 from Patent EP1572962. JD375534 - Sequence 356558 from Patent EP1572962. AK310870 - Homo sapiens cDNA, FLJ17912. CU689312 - Synthetic construct Homo sapiens gateway clone IMAGE:100017880 5' read RBL1 mRNA. JD461775 - Sequence 442799 from Patent EP1572962. JD406841 - Sequence 387865 from Patent EP1572962.
Biochemical and Signaling Pathways
BioCarta from NCI Cancer Genome Anatomy Project h_cellcyclePathway - Cyclins and Cell Cycle Regulation h_etsPathway - METS affect on Macrophage Differentiation
Reactome (by CSHL, EBI, and GO)
Protein P28749 (Reactome details) participates in the following event(s):
R-HSA-1363314 p107 (RBL1) binds CyclinE/A:CDK2 R-HSA-1363274 Dephosphorylation of p107 (RBL1) by PP2A R-HSA-1226095 Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex R-HSA-1227671 Recruitment of HDAC1 by p107 (RBL1) R-HSA-1363311 p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2 R-HSA-2127257 SMAD2/3:SMAD4 heterotrimer forms a complex with RBL1, E2F4/5 and DP1/2 R-HSA-6798282 TP53 and E2F4 bind the CDC25C gene R-HSA-8964550 The complex of HDAC1, RBL1 and E2F4 or HDAC1, RBL2, E2F4 or E2F5 binds E2F1 gene promoter R-HSA-8964561 The complex of HDAC1, RBL1 and E2F4 or HDAC1, RBL2, E2F4 or E2F5 binds MYBL2 gene promoter R-HSA-8964567 The complex of HDAC1, RBL1 and E2F4 or HDAC1, RBL2, E2F4 or E2F5 binds CDK1 gene promoter R-HSA-8964580 The complex of HDAC1, RBL1 and E2F4 or HDAC1, RBL2, E2F4 or E2F5 binds CCNA2 gene promoter R-HSA-1538133 G0 and Early G1 R-HSA-69231 Cyclin D associated events in G1 R-HSA-1362277 Transcription of E2F targets under negative control by DREAM complex R-HSA-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-453279 Mitotic G1-G1/S phases R-HSA-69236 G1 Phase R-HSA-2173793 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-6804114 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-69278 Cell Cycle (Mitotic) R-HSA-1362300 Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-170834 Signaling by TGF-beta Receptor Complex R-HSA-212436 Generic Transcription Pathway R-HSA-6791312 TP53 Regulates Transcription of Cell Cycle Genes R-HSA-1640170 Cell Cycle R-HSA-9006936 Signaling by TGF-beta family members R-HSA-73857 RNA Polymerase II Transcription R-HSA-3700989 Transcriptional Regulation by TP53 R-HSA-162582 Signal Transduction R-HSA-74160 Gene expression (Transcription)
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
