ID:RBL2_HUMAN DESCRIPTION: RecName: Full=Retinoblastoma-like protein 2; AltName: Full=130 kDa retinoblastoma-associated protein; Short=p130; AltName: Full=Retinoblastoma-related protein 2; Short=RBR-2; AltName: Full=pRb2; FUNCTION: Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor. SUBUNIT: Interacts with AATF. Interacts with SUV420H1, SUV420H2 and USP4 (By similarity). Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL2. Interacts with RINT1. INTERACTION: Q13574-2:DGKZ; NbExp=2; IntAct=EBI-971439, EBI-715527; P24610:Pax3 (xeno); NbExp=3; IntAct=EBI-971439, EBI-1208116; Q923E4:Sirt1 (xeno); NbExp=2; IntAct=EBI-971439, EBI-1802585; Q61412:Vsx2 (xeno); NbExp=4; IntAct=EBI-971439, EBI-1208174; SUBCELLULAR LOCATION: Nucleus. DEVELOPMENTAL STAGE: G0-restricted expression. PTM: During G0 and early G1 phase of the cell cycle, phosphorylated on Ser-639 and on 5 sites within the domain B. Phosphorylation on Ser-672 in G1 leads to its ubiquitin-dependent proteolysis. SIMILARITY: Belongs to the retinoblastoma protein (RB) family. WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/RBL2ID443.html";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF01857 - Retinoblastoma-associated protein B domain PF01858 - Retinoblastoma-associated protein A domain PF11934 - Domain of unknown function (DUF3452)
ModBase Predicted Comparative 3D Structure on Q08999
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006325 chromatin organization GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0007049 cell cycle GO:0010629 negative regulation of gene expression GO:0043550 regulation of lipid kinase activity GO:0051726 regulation of cell cycle
BC034490 - Homo sapiens retinoblastoma-like 2 (p130), mRNA (cDNA clone MGC:26535 IMAGE:4838444), complete cds. AK307881 - Homo sapiens cDNA, FLJ97829. X76061 - H.sapiens p130 mRNA for 130K protein. S67171 - Rbr-2=retinoblastoma susceptibility gene [human, HeLa S3 suspension cells, mRNA, 3448 nt]. X74594 - H.sapiens mRNA for Rb2/p130 protein. AK300047 - Homo sapiens cDNA FLJ53188 complete cds, highly similar to Retinoblastoma-like protein 2. BX537767 - Homo sapiens mRNA; cDNA DKFZp781K2028 (from clone DKFZp781K2028); complete cds. AK304283 - Homo sapiens cDNA FLJ53278 complete cds, highly similar to Retinoblastoma-like protein 2. DQ578636 - Homo sapiens piRNA piR-46748, complete sequence. AK129969 - Homo sapiens cDNA FLJ26459 fis, clone KDN03761, highly similar to Retinoblastoma-like protein 2. DQ574140 - Homo sapiens piRNA piR-42252, complete sequence. JD521475 - Sequence 502499 from Patent EP1572962. JD110470 - Sequence 91494 from Patent EP1572962. JD499767 - Sequence 480791 from Patent EP1572962. JD303217 - Sequence 284241 from Patent EP1572962. JD566139 - Sequence 547163 from Patent EP1572962. JD229380 - Sequence 210404 from Patent EP1572962. JD132664 - Sequence 113688 from Patent EP1572962. JD079942 - Sequence 60966 from Patent EP1572962. JD088908 - Sequence 69932 from Patent EP1572962. JD166577 - Sequence 147601 from Patent EP1572962. JD106564 - Sequence 87588 from Patent EP1572962. JD350054 - Sequence 331078 from Patent EP1572962. JD284962 - Sequence 265986 from Patent EP1572962. JD502040 - Sequence 483064 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q08999 (Reactome details) participates in the following event(s):
R-HSA-1363306 p130 (RBL2) binds Cyclin E/A:CDK2 R-HSA-1363276 Dephosphorylation of p130 (RBL2) by PP2A R-HSA-1363328 Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex R-HSA-1226094 Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex R-HSA-1227670 Recruitment of HDAC1 by p130 (RBL2) R-HSA-1362261 p130 (RBL2) associates with MuvB to form DREAM complex R-HSA-1363303 p130 (RBL2) in complex with E2F4/5:DP1/2 binds to cyclin E/A:CDK2 R-HSA-1363331 Ubiquitination of p130 (RBL2) by SCF (Skp2) R-HSA-8964465 DREAM complex binds the PCNA gene promoter R-HSA-8964471 DREAM complex binds the CDC25A gene promoter R-HSA-8964475 DREAM complex binds the TOP2A gene promoter R-HSA-8964482 DREAM complex binds the E2F1 gene promoter R-HSA-8964492 DREAM complex binds the RBL1 gene promoter R-HSA-8964498 DREAM complex binds the CDC6 gene promoter R-HSA-6798282 TP53 and E2F4 bind the CDC25C gene R-HSA-8964550 The complex of HDAC1, RBL1 and E2F4 or HDAC1, RBL2, E2F4 or E2F5 binds E2F1 gene promoter R-HSA-8964561 The complex of HDAC1, RBL1 and E2F4 or HDAC1, RBL2, E2F4 or E2F5 binds MYBL2 gene promoter R-HSA-8964567 The complex of HDAC1, RBL1 and E2F4 or HDAC1, RBL2, E2F4 or E2F5 binds CDK1 gene promoter R-HSA-8964580 The complex of HDAC1, RBL1 and E2F4 or HDAC1, RBL2, E2F4 or E2F5 binds CCNA2 gene promoter R-HSA-1538133 G0 and Early G1 R-HSA-69231 Cyclin D associated events in G1 R-HSA-453279 Mitotic G1-G1/S phases R-HSA-69236 G1 Phase R-HSA-1362277 Transcription of E2F targets under negative control by DREAM complex R-HSA-6804114 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-69278 Cell Cycle (Mitotic) R-HSA-1362300 Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-6791312 TP53 Regulates Transcription of Cell Cycle Genes R-HSA-1640170 Cell Cycle R-HSA-3700989 Transcriptional Regulation by TP53 R-HSA-212436 Generic Transcription Pathway R-HSA-73857 RNA Polymerase II Transcription R-HSA-74160 Gene expression (Transcription)
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
