Human Gene RBM15 (ENST00000369784.9_9) from GENCODE V47lift37
  Description: RNA binding motif protein 15, transcript variant 1 (from RefSeq NM_022768.5)
Gencode Transcript: ENST00000369784.9_9
Gencode Gene: ENSG00000162775.17_17
Transcript (Including UTRs)
   Position: hg19 chr1:110,881,999-110,889,299 Size: 7,301 Total Exon Count: 3 Strand: +
Coding Region
   Position: hg19 chr1:110,882,028-110,888,231 Size: 6,204 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:110,881,999-110,889,299)mRNA (may differ from genome)Protein (977 aa)
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WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: RBM15_HUMAN
DESCRIPTION: RecName: Full=Putative RNA-binding protein 15; AltName: Full=One-twenty two protein 1; AltName: Full=RNA-binding motif protein 15;
FUNCTION: May be implicated in HOX gene regulation.
SUBUNIT: Interacts with Epstein-Barr virus BSFL2/BMLF1.
SUBCELLULAR LOCATION: Nucleus.
PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.
DISEASE: Note=A chromosomal aberration involving RBM15 may be a cause of acute megakaryoblastic leukemia. Translocation t(1;22)(p13;q13) with MKL1. Although both reciprocal fusion transcripts are detected in acute megakaryoblastic leukemia (AMKL, FAB-M7), the RBM15-MKL1 chimeric protein has all the putative functional domains encoded by each gene and is the candidate oncogene.
SIMILARITY: Belongs to the RRM Spen family.
SIMILARITY: Contains 3 RRM (RNA recognition motif) domains.
SIMILARITY: Contains 1 SPOC domain.
SEQUENCE CAUTION: Sequence=BAB14088.1; Type=Erroneous initiation; Sequence=BAB15185.1; Type=Erroneous initiation;
WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/OTTID175.html";

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: RBM15
Diseases sorted by gene-association score: megakaryoblastic acute myeloid leukemia with t(1;22)(p13;q13)* (350), pancreatic cystadenoma (9), megakaryocytic leukemia (8), microcystic adenoma (6), kidney angiomyolipoma (5)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 8.37 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 86.41 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -0.1029-0.003 Picture PostScript Text
3' UTR -91.20410-0.222 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR012677 - Nucleotide-bd_a/b_plait
IPR000504 - RRM_dom
IPR016194 - SPOC-like
IPR012921 - SPOC_C
IPR010912 - SPOC_met

Pfam Domains:
PF00076 - RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
PF07744 - SPOC domain

SCOP Domains:
100939 - SPOC domain-like
54928 - RNA-binding domain, RBD

ModBase Predicted Comparative 3D Structure on Q96T37
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0005515 protein binding

Biological Process:
GO:0000398 mRNA splicing, via spliceosome
GO:0001569 branching involved in blood vessel morphogenesis
GO:0007221 positive regulation of transcription of Notch receptor target
GO:0016032 viral process
GO:0045638 negative regulation of myeloid cell differentiation
GO:0048536 spleen development
GO:0060412 ventricular septum morphogenesis
GO:0060674 placenta blood vessel development
GO:0045892 negative regulation of transcription, DNA-templated

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0016020 membrane
GO:0016607 nuclear speck
GO:0031965 nuclear membrane


-  Descriptions from all associated GenBank mRNAs
  BC042587 - Homo sapiens cDNA clone IMAGE:4837213, containing frame-shift errors.
AF368062 - Homo sapiens putative RNA-binding motif protein 15 short form (RBM15) mRNA, complete cds, alternatively spliced.
AF368063 - Homo sapiens putative RNA-binding motif protein 15 short form plus alternative exon (RBM15) mRNA, complete cds, alternatively spliced.
BC098140 - Homo sapiens RNA binding motif protein 15, mRNA (cDNA clone MGC:119583 IMAGE:40008573), complete cds.
BC103493 - Homo sapiens RNA binding motif protein 15, mRNA (cDNA clone MGC:119582 IMAGE:40008572), complete cds.
BC103507 - Homo sapiens RNA binding motif protein 15, mRNA (cDNA clone MGC:119585 IMAGE:40008575), complete cds.
BC103660 - Homo sapiens cDNA clone IMAGE:40008574.
KJ903098 - Synthetic construct Homo sapiens clone ccsbBroadEn_12492 RBM15 gene, encodes complete protein.
BC047479 - Homo sapiens RNA binding motif protein 15, mRNA (cDNA clone IMAGE:5267759), partial cds.
AK022541 - Homo sapiens cDNA FLJ12479 fis, clone NT2RM1001059, weakly similar to NUCLEAR POLYADENYLATED RNA-BINDING PROTEIN NAB4.
BC006397 - Homo sapiens RNA binding motif protein 15, mRNA (cDNA clone IMAGE:4298786), partial cds.
BC062316 - Homo sapiens RNA binding motif protein 15, mRNA (cDNA clone IMAGE:4869518), partial cds.
KJ906302 - Synthetic construct Homo sapiens clone ccsbBroadEn_15972 RBM15 gene, encodes complete protein.
AB209680 - Homo sapiens mRNA for RNA binding motif protein 15 variant protein.
AF368064 - Homo sapiens putative RNA-binding motif protein 15 long form (RBM15) mRNA, complete cds, alternatively spliced.
AK025596 - Homo sapiens cDNA: FLJ21943 fis, clone HEP04547.
AF364035 - Homo sapiens RNA-binding motif protein 15/megakaryoblastic leukemia-1 fusion protein (RBM15/MKL1 fusion) mRNA, partial cds.
BC000841 - Homo sapiens RNA binding motif protein 15, mRNA (cDNA clone IMAGE:3457406), partial cds.
AF364037 - Homo sapiens megakaryoblastic leukemia-1 protein/RNA-binding motif protein 15s + ae fusion protein (MKL1/RBM15 fusion) mRNA, complete cds.
BC010891 - Homo sapiens RNA binding motif protein 15, mRNA (cDNA clone IMAGE:4278414), with apparent retained intron.
AF364036 - Homo sapiens megakaryoblastic leukemia-1 protein/RNA-binding motif protein 15s fusion protein (MKL1/RBM15 fusion) mRNA, complete cds.
JD566789 - Sequence 547813 from Patent EP1572962.
JD273926 - Sequence 254950 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A1A693, ENST00000369784.1, ENST00000369784.2, ENST00000369784.3, ENST00000369784.4, ENST00000369784.5, ENST00000369784.6, ENST00000369784.7, ENST00000369784.8, NM_022768, OTT , OTT1 , Q3ZB86, Q4V760, Q5D058, Q5T613, Q86VW9, Q96PE4, Q96SC5, Q96SC6, Q96SC9, Q96SD0, Q96T37, Q96T38, Q9BRA5, Q9H6R8, Q9H9Y0, RBM15 , RBM15_HUMAN, uc318hvv.1, uc318hvv.2
UCSC ID: ENST00000369784.9_9
RefSeq Accession: NM_022768.5
Protein: Q96T37 (aka RBM15_HUMAN or RBMF_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.