Human Gene RBM33 (ENST00000401878.8_11) from GENCODE V47lift37
  Description: RNA binding motif protein 33 (from RefSeq NM_053043.3)
Gencode Transcript: ENST00000401878.8_11
Gencode Gene: ENSG00000184863.11_16
Transcript (Including UTRs)
   Position: hg19 chr7:155,437,355-155,574,174 Size: 136,820 Total Exon Count: 18 Strand: +
Coding Region
   Position: hg19 chr7:155,437,571-155,567,735 Size: 130,165 Coding Exon Count: 18 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr7:155,437,355-155,574,174)mRNA (may differ from genome)Protein (1170 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIPubMedUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: RBM33_HUMAN
DESCRIPTION: RecName: Full=RNA-binding protein 33; AltName: Full=Proline-rich protein 8; AltName: Full=RNA-binding motif protein 33;
SIMILARITY: Contains 1 RRM (RNA recognition motif) domain.
SEQUENCE CAUTION: Sequence=AAH93947.1; Type=Erroneous initiation; Sequence=AAH93949.1; Type=Erroneous initiation; Sequence=AAS01989.1; Type=Erroneous gene model prediction; Sequence=AAS02026.1; Type=Erroneous gene model prediction; Sequence=AAS07551.1; Type=Erroneous gene model prediction; Sequence=CAB70894.1; Type=Miscellaneous discrepancy; Note=Intron retention; Sequence=EAL23911.1; Type=Erroneous gene model prediction; Sequence=EAL23912.1; Type=Erroneous gene model prediction; Sequence=EAX04539.1; Type=Erroneous gene model prediction;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 16.85 RPKM in Brain - Cerebellum
Total median expression: 428.06 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -103.30216-0.478 Picture PostScript Text
3' UTR -2072.206439-0.322 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR012677 - Nucleotide-bd_a/b_plait
IPR000504 - RRM_dom

SCOP Domains:
54928 - RNA-binding domain, RBD

ModBase Predicted Comparative 3D Structure on Q96EV2
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003676 nucleic acid binding
GO:0003723 RNA binding


-  Descriptions from all associated GenBank mRNAs
  BC011923 - Homo sapiens RNA binding motif protein 33, mRNA (cDNA clone IMAGE:4542314), complete cds.
AK307515 - Homo sapiens cDNA, FLJ97463.
KJ903906 - Synthetic construct Homo sapiens clone ccsbBroadEn_13300 RBM33 gene, encodes complete protein.
JD027408 - Sequence 8432 from Patent EP1572962.
JD031007 - Sequence 12031 from Patent EP1572962.
AL137724 - Homo sapiens mRNA; cDNA DKFZp434D1319 (from clone DKFZp434D1319); partial cds.
JD328200 - Sequence 309224 from Patent EP1572962.
JD475812 - Sequence 456836 from Patent EP1572962.
JD529989 - Sequence 511013 from Patent EP1572962.
JD507036 - Sequence 488060 from Patent EP1572962.
JD090500 - Sequence 71524 from Patent EP1572962.
JD065607 - Sequence 46631 from Patent EP1572962.
JD409934 - Sequence 390958 from Patent EP1572962.
JD202825 - Sequence 183849 from Patent EP1572962.
AK301179 - Homo sapiens cDNA FLJ60909 complete cds, highly similar to Proline-rich protein 8.
JD179315 - Sequence 160339 from Patent EP1572962.
JD075306 - Sequence 56330 from Patent EP1572962.
JD339247 - Sequence 320271 from Patent EP1572962.
JD107450 - Sequence 88474 from Patent EP1572962.
JD470350 - Sequence 451374 from Patent EP1572962.
JD065030 - Sequence 46054 from Patent EP1572962.
JD464356 - Sequence 445380 from Patent EP1572962.
JD062474 - Sequence 43498 from Patent EP1572962.
JD253415 - Sequence 234439 from Patent EP1572962.
JD418335 - Sequence 399359 from Patent EP1572962.
JD554906 - Sequence 535930 from Patent EP1572962.
JD079717 - Sequence 60741 from Patent EP1572962.
JD516330 - Sequence 497354 from Patent EP1572962.
JD318680 - Sequence 299704 from Patent EP1572962.
JD439167 - Sequence 420191 from Patent EP1572962.
JD117353 - Sequence 98377 from Patent EP1572962.
JD431491 - Sequence 412515 from Patent EP1572962.
JD484306 - Sequence 465330 from Patent EP1572962.
JD482470 - Sequence 463494 from Patent EP1572962.
JD207867 - Sequence 188891 from Patent EP1572962.
JD358458 - Sequence 339482 from Patent EP1572962.
JD260664 - Sequence 241688 from Patent EP1572962.
JD457090 - Sequence 438114 from Patent EP1572962.
AL832196 - Homo sapiens mRNA; cDNA DKFZp686F102 (from clone DKFZp686F102).
JD062660 - Sequence 43684 from Patent EP1572962.
JD123728 - Sequence 104752 from Patent EP1572962.
JD476632 - Sequence 457656 from Patent EP1572962.
JD116480 - Sequence 97504 from Patent EP1572962.
BC093949 - Homo sapiens RNA binding motif protein 33, mRNA (cDNA clone IMAGE:7939794), complete cds.
BC093947 - Homo sapiens RNA binding motif protein 33, mRNA (cDNA clone IMAGE:7939792), complete cds.
JD519374 - Sequence 500398 from Patent EP1572962.
JD452323 - Sequence 433347 from Patent EP1572962.
JD057557 - Sequence 38581 from Patent EP1572962.
AK056415 - Homo sapiens cDNA FLJ31853 fis, clone NT2RP7000876.
JD515921 - Sequence 496945 from Patent EP1572962.
JD376159 - Sequence 357183 from Patent EP1572962.
JD185181 - Sequence 166205 from Patent EP1572962.
JD267201 - Sequence 248225 from Patent EP1572962.
DQ587919 - Homo sapiens piRNA piR-55031, complete sequence.
JD189636 - Sequence 170660 from Patent EP1572962.
JD127461 - Sequence 108485 from Patent EP1572962.
JD372646 - Sequence 353670 from Patent EP1572962.
JD098209 - Sequence 79233 from Patent EP1572962.
JD499260 - Sequence 480284 from Patent EP1572962.
AK055645 - Homo sapiens cDNA FLJ31083 fis, clone HSYRA2001638.
JD055786 - Sequence 36810 from Patent EP1572962.
JD220740 - Sequence 201764 from Patent EP1572962.
JD252318 - Sequence 233342 from Patent EP1572962.
JD391990 - Sequence 373014 from Patent EP1572962.
JD508892 - Sequence 489916 from Patent EP1572962.
JD541727 - Sequence 522751 from Patent EP1572962.
JD198535 - Sequence 179559 from Patent EP1572962.
JD298495 - Sequence 279519 from Patent EP1572962.
JD078927 - Sequence 59951 from Patent EP1572962.
JD506366 - Sequence 487390 from Patent EP1572962.
JD491458 - Sequence 472482 from Patent EP1572962.
JD327066 - Sequence 308090 from Patent EP1572962.
JD068809 - Sequence 49833 from Patent EP1572962.
JD453586 - Sequence 434610 from Patent EP1572962.
DQ601526 - Homo sapiens piRNA piR-39592, complete sequence.
JD353566 - Sequence 334590 from Patent EP1572962.
JD339172 - Sequence 320196 from Patent EP1572962.
JD072675 - Sequence 53699 from Patent EP1572962.
JD282395 - Sequence 263419 from Patent EP1572962.
JD306499 - Sequence 287523 from Patent EP1572962.
JD453585 - Sequence 434609 from Patent EP1572962.
JD270590 - Sequence 251614 from Patent EP1572962.
JD221510 - Sequence 202534 from Patent EP1572962.
JD221511 - Sequence 202535 from Patent EP1572962.
JD301030 - Sequence 282054 from Patent EP1572962.
JD103553 - Sequence 84577 from Patent EP1572962.
DL492202 - Novel nucleic acids.
JD051603 - Sequence 32627 from Patent EP1572962.
JD235636 - Sequence 216660 from Patent EP1572962.
JD038774 - Sequence 19798 from Patent EP1572962.
JD101040 - Sequence 82064 from Patent EP1572962.
JD539307 - Sequence 520331 from Patent EP1572962.
JD324062 - Sequence 305086 from Patent EP1572962.
JD552597 - Sequence 533621 from Patent EP1572962.
JD561919 - Sequence 542943 from Patent EP1572962.
JD298457 - Sequence 279481 from Patent EP1572962.
JD392870 - Sequence 373894 from Patent EP1572962.
JD077035 - Sequence 58059 from Patent EP1572962.
JD435191 - Sequence 416215 from Patent EP1572962.
JD084264 - Sequence 65288 from Patent EP1572962.
AK055460 - Homo sapiens cDNA FLJ30898 fis, clone FEBRA2005572.
JD507203 - Sequence 488227 from Patent EP1572962.
DQ587177 - Homo sapiens piRNA piR-54289, complete sequence.
JD391861 - Sequence 372885 from Patent EP1572962.
JD081331 - Sequence 62355 from Patent EP1572962.
JD327471 - Sequence 308495 from Patent EP1572962.
JD347412 - Sequence 328436 from Patent EP1572962.
JD514381 - Sequence 495405 from Patent EP1572962.
JD538959 - Sequence 519983 from Patent EP1572962.
JD195555 - Sequence 176579 from Patent EP1572962.
JD118610 - Sequence 99634 from Patent EP1572962.
JD053857 - Sequence 34881 from Patent EP1572962.
JD250248 - Sequence 231272 from Patent EP1572962.
JD358596 - Sequence 339620 from Patent EP1572962.
JD354631 - Sequence 335655 from Patent EP1572962.
JD239658 - Sequence 220682 from Patent EP1572962.
JD528296 - Sequence 509320 from Patent EP1572962.
JD325634 - Sequence 306658 from Patent EP1572962.
JD524584 - Sequence 505608 from Patent EP1572962.
JD414074 - Sequence 395098 from Patent EP1572962.
JD173194 - Sequence 154218 from Patent EP1572962.
JD276597 - Sequence 257621 from Patent EP1572962.
JD297507 - Sequence 278531 from Patent EP1572962.
JD150581 - Sequence 131605 from Patent EP1572962.
JD216941 - Sequence 197965 from Patent EP1572962.
JD491351 - Sequence 472375 from Patent EP1572962.
JD381381 - Sequence 362405 from Patent EP1572962.
JD555492 - Sequence 536516 from Patent EP1572962.
JD416424 - Sequence 397448 from Patent EP1572962.
JD294644 - Sequence 275668 from Patent EP1572962.
JD525254 - Sequence 506278 from Patent EP1572962.
JD501433 - Sequence 482457 from Patent EP1572962.
JD525332 - Sequence 506356 from Patent EP1572962.
JD437570 - Sequence 418594 from Patent EP1572962.
JD293865 - Sequence 274889 from Patent EP1572962.
LQ980566 - Sequence 212 from Patent WO2013050532.

-  Other Names for This Gene
  Alternate Gene Symbols: A4D244, B5MC24, ENST00000401878.1, ENST00000401878.2, ENST00000401878.3, ENST00000401878.4, ENST00000401878.5, ENST00000401878.6, ENST00000401878.7, NM_053043, PRR8, Q52LF5, Q75LN9, Q75ML5, Q96EV2, Q9NSV0, RBM33_HUMAN, uc319boi.1, uc319boi.2
UCSC ID: ENST00000401878.8_11
RefSeq Accession: NM_053043.3
Protein: Q96EV2 (aka RBM33_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.