ID:RBMX_HUMAN DESCRIPTION: RecName: Full=RNA-binding motif protein, X chromosome; AltName: Full=Glycoprotein p43; AltName: Full=Heterogeneous nuclear ribonucleoprotein G; Short=hnRNP G; Contains: RecName: Full=RNA-binding motif protein, X chromosome, N-terminally processed; FUNCTION: RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue-specific regulation of gene transcription and alternative splicing of several pre-mRNAs. Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter; may thus be involved in tumor suppression. When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates pre-mRNA alternative splice site selection. Can either activate or suppress exon inclusion; acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN2. Represses the splicing of MAPT/Tau exon 10. Binds preferentially to single- stranded 5'-CC[A/C]-rich RNA sequence motifs localized in a single-stranded conformation; probably binds RNA as a homodimer. Binds non-specifically to pre-mRNAs. Plays also a role in the cytoplasmic TNFR1 trafficking pathways; promotes both the IL-1- beta-mediated inducible proteolytic cleavage of TNFR1 ectodomains and the release of TNFR1 exosome-like vesicles to the extracellular compartment. SUBUNIT: Homomultimer. Interacts with SAFB/SAFB1 (By similarity). Found in the supraspliceosome complex. Identified in the spliceosome C complex. Interacts with KHDRBS3. Forms a complex with ILF2, ILF3, YLPM1, KHDRBS1, NCOA5 and PPP1CA. Interacts with CLK2, KHDRBS2, SAFB, TRA2B and YTHDC1. Interacts with ERAP1; the interaction is RNA-independent. INTERACTION: Q5VWX1:KHDRBS2; NbExp=2; IntAct=EBI-743526, EBI-742808; SUBCELLULAR LOCATION: Nucleus. Note=Component of ribonucleosomes. Localizes in numerous small granules in the nucleus. TISSUE SPECIFICITY: Expressed strongly in oral keratinocytes, but only weakly detected in oral squamous cell carcinomas (at protein level). DOMAIN: The RRM domain is necessary for RNA-binding, but not for splice site selection, indicating that its splicing activity does not require direct binding to RNA (By similarity). PTM: O-glycosylated. PTM: Arg-185 is dimethylated, probably to asymmetric dimethylarginine. PTM: Cleavage of initiator Met is partial. If Met-1 is not removed, it is acetylated. If it is removed, Val-2 is acetylated. SIMILARITY: Contains 1 RRM (RNA recognition motif) domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P38159
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000381 regulation of alternative mRNA splicing, via spliceosome GO:0000398 mRNA splicing, via spliceosome GO:0001649 osteoblast differentiation GO:0006351 transcription, DNA-templated GO:0006366 transcription from RNA polymerase II promoter GO:0006376 mRNA splice site selection GO:0006397 mRNA processing GO:0006509 membrane protein ectodomain proteolysis GO:0008380 RNA splicing GO:0016070 RNA metabolic process GO:0045893 positive regulation of transcription, DNA-templated GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0048025 negative regulation of mRNA splicing, via spliceosome GO:0048026 positive regulation of mRNA splicing, via spliceosome GO:0051259 protein oligomerization GO:0051260 protein homooligomerization GO:0071347 cellular response to interleukin-1
BX647131 - Homo sapiens mRNA; cDNA DKFZp686M09166 (from clone DKFZp686M09166). AK304868 - Homo sapiens cDNA FLJ59107 complete cds, moderately similar to Heterogeneous nuclear ribonucleoprotein G. Z69915 - H.sapiens mRNA (clone ICRFp507L1876). AK091520 - Homo sapiens cDNA FLJ34201 fis, clone FCBBF3019714, highly similar to HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN G. Z23064 - H.sapiens mRNA gene for hnRNP G protein. BC006550 - Homo sapiens RNA binding motif protein, X-linked, mRNA (cDNA clone MGC:2471 IMAGE:3010123), complete cds. BC007435 - Homo sapiens RNA binding motif protein, X-linked, mRNA (cDNA clone MGC:4146 IMAGE:3010123), complete cds. AK096015 - Homo sapiens cDNA FLJ38696 fis, clone KIDNE2001931, highly similar to HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN G. JD284843 - Sequence 265867 from Patent EP1572962. JD120317 - Sequence 101341 from Patent EP1572962. JD456366 - Sequence 437390 from Patent EP1572962. JD466068 - Sequence 447092 from Patent EP1572962. JD379035 - Sequence 360059 from Patent EP1572962. JD273966 - Sequence 254990 from Patent EP1572962. JD549935 - Sequence 530959 from Patent EP1572962. JD184356 - Sequence 165380 from Patent EP1572962. JD110014 - Sequence 91038 from Patent EP1572962. JD450611 - Sequence 431635 from Patent EP1572962. JD309456 - Sequence 290480 from Patent EP1572962. JD074451 - Sequence 55475 from Patent EP1572962. JD048689 - Sequence 29713 from Patent EP1572962. JD475043 - Sequence 456067 from Patent EP1572962. BC073747 - Homo sapiens cDNA clone IMAGE:6208426, **** WARNING: chimeric clone ****. JD346822 - Sequence 327846 from Patent EP1572962. JD181067 - Sequence 162091 from Patent EP1572962. JD312276 - Sequence 293300 from Patent EP1572962. AK304573 - Homo sapiens cDNA FLJ54953 complete cds, highly similar to Heterogeneous nuclear ribonucleoprotein G. JD068158 - Sequence 49182 from Patent EP1572962. AY464692 - Homo sapiens heterogeneous nuclear ribonucleoprotein G mRNA, complete cds. DQ893211 - Synthetic construct clone IMAGE:100005841; FLH195282.01X; RZPDo839A09152D RNA binding motif protein, X-linked (RBMX) gene, encodes complete protein. KJ893634 - Synthetic construct Homo sapiens clone ccsbBroadEn_03028 RBMX gene, encodes complete protein. DQ896540 - Synthetic construct Homo sapiens clone IMAGE:100011000; FLH195278.01L; RZPDo839A09151D RNA binding motif protein, X-linked (RBMX) gene, encodes complete protein. JD081029 - Sequence 62053 from Patent EP1572962. AK309911 - Homo sapiens cDNA, FLJ99952. LF373916 - JP 2014500723-A/181419: Polycomb-Associated Non-Coding RNAs. LF334082 - JP 2014500723-A/141585: Polycomb-Associated Non-Coding RNAs. JD317503 - Sequence 298527 from Patent EP1572962. MA609493 - JP 2018138019-A/181419: Polycomb-Associated Non-Coding RNAs. MA569659 - JP 2018138019-A/141585: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein P38159 (Reactome details) participates in the following event(s):
R-HSA-72103 Formation of pre-mRNPs R-HSA-72107 Formation of the Spliceosomal E complex R-HSA-72124 Formation of the Spliceosomal A Complex R-HSA-72127 Formation of the Spliceosomal B Complex R-HSA-72130 Formation of an intermediate Spliceosomal C (Bact) complex R-HSA-72143 Lariat Formation and 5'-Splice Site Cleavage R-HSA-72139 Formation of the active Spliceosomal C (B*) complex R-HSA-156661 Formation of Exon Junction Complex R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA R-HSA-72163 mRNA Splicing - Major Pathway R-HSA-8953854 Metabolism of RNA R-HSA-72172 mRNA Splicing
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
