Human Gene RBMXL2 (ENST00000306904.7_4) from GENCODE V47lift37
  Description: RBMX like 2 (from RefSeq NM_014469.5)
Gencode Transcript: ENST00000306904.7_4
Gencode Gene: ENSG00000170748.7_8
Transcript (Including UTRs)
   Position: hg19 chr11:7,110,229-7,112,379 Size: 2,151 Total Exon Count: 1 Strand: +
Coding Region
   Position: hg19 chr11:7,110,352-7,111,530 Size: 1,179 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersGene AllelesRNA-Seq Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Model InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr11:7,110,229-7,112,379)mRNA (may differ from genome)Protein (392 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MGIOMIMPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: RMXL2_HUMAN
DESCRIPTION: RecName: Full=RNA-binding motif protein, X-linked-like-2; AltName: Full=Testis-specific heterogeneous nuclear ribonucleoprotein G-T; Short=hnRNP G-T;
SUBCELLULAR LOCATION: Nucleus.
TISSUE SPECIFICITY: Expressed predominantly in spermatocytes and less in round spermatids (at protein level). Expressed in germ cells.
SIMILARITY: Contains 1 RRM (RNA recognition motif) domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 35.58 RPKM in Testis
Total median expression: 36.32 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -44.10123-0.359 Picture PostScript Text
3' UTR -172.40849-0.203 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR012677 - Nucleotide-bd_a/b_plait
IPR012604 - RBM1CTR
IPR000504 - RRM_dom

Pfam Domains:
PF00076 - RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
PF08081 - RBM1CTR (NUC064) family

SCOP Domains:
54928 - RNA-binding domain, RBD

ModBase Predicted Comparative 3D Structure on O75526
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003676 nucleic acid binding
GO:0003723 RNA binding

Cellular Component:
GO:0005634 nucleus


-  Descriptions from all associated GenBank mRNAs
  AK292271 - Homo sapiens cDNA FLJ76931 complete cds, highly similar to Homo sapiens testes-specific heterogenous nuclear ribonucleoprotein G-T, mRNA.
AF069682 - Homo sapiens testes specific heterogenous nuclear ribonucleoprotein G-T (hnRNPG-T) mRNA, complete cds.
JD460662 - Sequence 441686 from Patent EP1572962.
JD159570 - Sequence 140594 from Patent EP1572962.
JD131485 - Sequence 112509 from Patent EP1572962.
BC057796 - Homo sapiens RNA binding motif protein, X-linked-like 2, mRNA (cDNA clone MGC:71651 IMAGE:5261317), complete cds.
BC029295 - Homo sapiens RNA binding motif protein, X-linked-like 2, mRNA (cDNA clone IMAGE:5169888).
AB527964 - Synthetic construct DNA, clone: pF1KE0664, Homo sapiens RBMXL2 gene for RNA binding motif protein, X-linked-like 2, without stop codon, in Flexi system.
JD317518 - Sequence 298542 from Patent EP1572962.
JD059034 - Sequence 40058 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000306904.1, ENST00000306904.2, ENST00000306904.3, ENST00000306904.4, ENST00000306904.5, ENST00000306904.6, HNRNPGT, NM_014469, O75526, Q6PEZ2, Q9NQU0, RMXL2_HUMAN, uc317nyk.1, uc317nyk.2
UCSC ID: ENST00000306904.7_4
RefSeq Accession: NM_014469.5
Protein: O75526 (aka RMXL2_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.