Human Gene RBP1 (ENST00000672186.1_7) from GENCODE V47lift37
  Description: retinol binding protein 1, transcript variant 1 (from RefSeq NM_002899.5)
Gencode Transcript: ENST00000672186.1_7
Gencode Gene: ENSG00000114115.11_13
Transcript (Including UTRs)
   Position: hg19 chr3:139,236,280-139,258,584 Size: 22,305 Total Exon Count: 4 Strand: -
Coding Region
   Position: hg19 chr3:139,236,469-139,258,560 Size: 22,092 Coding Exon Count: 4 

Page IndexSequence and LinksPrimersMalaCardsCTDGene Alleles
Microarray ExpressionRNA StructureOther SpeciesmRNA DescriptionsPathwaysOther Names
Model InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr3:139,236,280-139,258,584)mRNA (may differ from genome)Protein (197 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: RBP1
Diseases sorted by gene-association score: blepharophimosis (11), epithelioid cell melanoma (11), juxtacortical chondroma (9), keratoacanthoma (7), renal-hepatic-pancreatic dysplasia (5), fetal alcohol spectrum disorder (5), fetal alcohol syndrome (5), keratosis, seborrheic, somatic (4), dowling-degos disease 1 (4)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -7.7024-0.321 Picture PostScript Text
3' UTR -52.00189-0.275 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
      
      

-  Descriptions from all associated GenBank mRNAs
  JD310094 - Sequence 291118 from Patent EP1572962.
M11433 - Human cellular retinol-binding protein mRNA, complete cds.
JD243447 - Sequence 224471 from Patent EP1572962.
JD317361 - Sequence 298385 from Patent EP1572962.
BC121052 - Homo sapiens retinol binding protein 1, cellular, mRNA (cDNA clone MGC:149753 IMAGE:40118103), complete cds.
AK290315 - Homo sapiens cDNA FLJ76382 complete cds, highly similar to Homo sapiens retinol binding protein 1, cellular (RBP1), mRNA.
JD347144 - Sequence 328168 from Patent EP1572962.
EU831403 - Synthetic construct Homo sapiens clone HAIB:100066432; DKFZo008A0117 retinol binding protein 1, cellular protein (RBP1) gene, encodes complete protein.
EU831495 - Synthetic construct Homo sapiens clone HAIB:100066524; DKFZo004A0118 retinol binding protein 1, cellular protein (RBP1) gene, encodes complete protein.
CR541979 - Homo sapiens full open reading frame cDNA clone RZPDo834A0235D for gene RBP1, retinol binding protein 1, cellular; complete cds, incl. stopcodon.
KJ901699 - Synthetic construct Homo sapiens clone ccsbBroadEn_11093 RBP1 gene, encodes complete protein.
AB464149 - Synthetic construct DNA, clone: pF1KB6724, Homo sapiens RBP1 gene for retinol binding protein 1, without stop codon, in Flexi system.
CR542005 - Homo sapiens full open reading frame cDNA clone RZPDo834G0135D for gene RBP1, retinol binding protein 1, cellular; complete cds, without stopcodon.
M36809 - Human cellular retinol-binding protein (CRBP) mRNA, 5' end.
AK301684 - Homo sapiens cDNA FLJ50903 complete cds, moderately similar to Retinol-binding protein I, cellular.
AK307378 - Homo sapiens cDNA, FLJ97326.
AK309492 - Homo sapiens cDNA, FLJ99533.
JD141129 - Sequence 122153 from Patent EP1572962.
JD056338 - Sequence 37362 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  BioCyc Knowledge Library
PWY-6857 - retinol biosynthesis
PWY-6861 - the visual cycle I (vertebrates)
PWY-6872 - retinoate biosynthesis I
PWY-6875 - retinoate biosynthesis II

-  Other Names for This Gene
  Alternate Gene Symbols: A0A0A0MQT0, A0A0A0MQT0_HUMAN, hCG_16055 , NM_002899, RBP1 , uc329wlo.1, uc329wlo.2
UCSC ID: ENST00000672186.1_7
RefSeq Accession: NM_002899.5

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.