Human Gene RC3H2 (ENST00000357244.7_8) from GENCODE V47lift37
  Description: ring finger and CCCH-type domains 2, transcript variant 5 (from RefSeq NM_001354482.2)
Gencode Transcript: ENST00000357244.7_8
Gencode Gene: ENSG00000056586.16_11
Transcript (Including UTRs)
   Position: hg19 chr9:125,606,835-125,667,638 Size: 60,804 Total Exon Count: 21 Strand: -
Coding Region
   Position: hg19 chr9:125,611,906-125,659,788 Size: 47,883 Coding Exon Count: 20 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr9:125,606,835-125,667,638)mRNA (may differ from genome)Protein (1191 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: RC3H2_HUMAN
DESCRIPTION: RecName: Full=RING finger and CCCH-type zinc finger domain-containing protein 2; AltName: Full=Membrane-associated nucleic acid-binding protein; AltName: Full=RING finger protein 164;
SUBUNIT: Binds DNA.
SUBCELLULAR LOCATION: Cytoplasm, perinuclear region. Endomembrane system. Note=Membrane-associated. Primarily localizes to the perinuclear space, probably to the endoplasmic reticulum or trans- Golgi network.
TISSUE SPECIFICITY: Expressed in spleen, testis, ovary and small intestine.
SIMILARITY: Contains 1 C3H1-type zinc finger.
SIMILARITY: Contains 1 RING-type zinc finger.
SEQUENCE CAUTION: Sequence=BAA91340.1; Type=Erroneous initiation; Sequence=BAB15634.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 7.25 RPKM in Brain - Cerebellar Hemisphere
Total median expression: 238.51 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -146.40317-0.462 Picture PostScript Text
3' UTR -1269.305071-0.250 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000571 - Znf_CCCH
IPR001841 - Znf_RING
IPR013083 - Znf_RING/FYVE/PHD
IPR017907 - Znf_RING_CS

Pfam Domains:
PF00642 - Zinc finger C-x8-C-x5-C-x3-H type (and similar)
PF13445 - RING-type zinc-finger
PF18386 - Roquin II domain

SCOP Domains:
57850 - RING/U-box
57903 - FYVE/PHD zinc finger
90229 - CCCH zinc finger

ModBase Predicted Comparative 3D Structure on Q9HBD1
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0003725 double-stranded RNA binding
GO:0003729 mRNA binding
GO:0004842 ubiquitin-protein transferase activity
GO:0016740 transferase activity
GO:0035613 RNA stem-loop binding
GO:0046872 metal ion binding

Biological Process:
GO:0000209 protein polyubiquitination
GO:0001782 B cell homeostasis
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0009791 post-embryonic development
GO:0010468 regulation of gene expression
GO:0010608 posttranscriptional regulation of gene expression
GO:0016567 protein ubiquitination
GO:0035264 multicellular organism growth
GO:0042098 T cell proliferation
GO:0043029 T cell homeostasis
GO:0048286 lung alveolus development
GO:0048535 lymph node development
GO:0048536 spleen development
GO:0050852 T cell receptor signaling pathway
GO:0060173 limb development
GO:0061470 T follicular helper cell differentiation
GO:1901224 positive regulation of NIK/NF-kappaB signaling
GO:2000320 negative regulation of T-helper 17 cell differentiation
GO:2000628 regulation of miRNA metabolic process

Cellular Component:
GO:0000932 P-body
GO:0005737 cytoplasm
GO:0009986 cell surface
GO:0016020 membrane
GO:0043231 intracellular membrane-bounded organelle


-  Descriptions from all associated GenBank mRNAs
  KJ899131 - Synthetic construct Homo sapiens clone ccsbBroadEn_08525 STRBP gene, encodes complete protein.
KJ894450 - Synthetic construct Homo sapiens clone ccsbBroadEn_03844 DENND1A gene, encodes complete protein.
LF205679 - JP 2014500723-A/13182: Polycomb-Associated Non-Coding RNAs.
AK123569 - Homo sapiens cDNA FLJ41575 fis, clone CTONG2019226.
AK125196 - Homo sapiens cDNA FLJ43206 fis, clone FEBRA2009419.
AL833455 - Homo sapiens mRNA; cDNA DKFZp686I10116 (from clone DKFZp686I10116).
LF347036 - JP 2014500723-A/154539: Polycomb-Associated Non-Coding RNAs.
LF347037 - JP 2014500723-A/154540: Polycomb-Associated Non-Coding RNAs.
LF347038 - JP 2014500723-A/154541: Polycomb-Associated Non-Coding RNAs.
LF347039 - JP 2014500723-A/154542: Polycomb-Associated Non-Coding RNAs.
LF347040 - JP 2014500723-A/154543: Polycomb-Associated Non-Coding RNAs.
AL833177 - Homo sapiens mRNA; cDNA DKFZp667B165 (from clone DKFZp667B165).
AK027042 - Homo sapiens cDNA: FLJ23389 fis, clone HEP17027.
AF255304 - Homo sapiens membrane-associated nucleic acid binding protein mRNA, complete cds.
DQ592307 - Homo sapiens piRNA piR-59419, complete sequence.
LF347041 - JP 2014500723-A/154544: Polycomb-Associated Non-Coding RNAs.
LF347042 - JP 2014500723-A/154545: Polycomb-Associated Non-Coding RNAs.
AF255303 - Homo sapiens membrane-associated nucleic acid binding protein mRNA, partial cds.
AK000720 - Homo sapiens cDNA FLJ20713 fis, clone HUV00966.
AL834431 - Homo sapiens mRNA; cDNA DKFZp762N035 (from clone DKFZp762N035).
AK000308 - Homo sapiens cDNA FLJ20301 fis, clone HEP06569.
AK226010 - Homo sapiens mRNA for Splice isoform 4 of Q9HBD1 variant, clone: FCC108A11.
LF347043 - JP 2014500723-A/154546: Polycomb-Associated Non-Coding RNAs.
LF347044 - JP 2014500723-A/154547: Polycomb-Associated Non-Coding RNAs.
LF347045 - JP 2014500723-A/154548: Polycomb-Associated Non-Coding RNAs.
LF347046 - JP 2014500723-A/154549: Polycomb-Associated Non-Coding RNAs.
LF347047 - JP 2014500723-A/154550: Polycomb-Associated Non-Coding RNAs.
LF347048 - JP 2014500723-A/154551: Polycomb-Associated Non-Coding RNAs.
LF347049 - JP 2014500723-A/154552: Polycomb-Associated Non-Coding RNAs.
LF347054 - JP 2014500723-A/154557: Polycomb-Associated Non-Coding RNAs.
LF347055 - JP 2014500723-A/154558: Polycomb-Associated Non-Coding RNAs.
BC044642 - Homo sapiens ring finger and CCCH-type zinc finger domains 2, mRNA (cDNA clone IMAGE:5455191), complete cds.
KJ902662 - Synthetic construct Homo sapiens clone ccsbBroadEn_12056 RC3H2 gene, encodes complete protein.
LF347056 - JP 2014500723-A/154559: Polycomb-Associated Non-Coding RNAs.
LF347059 - JP 2014500723-A/154562: Polycomb-Associated Non-Coding RNAs.
CU692230 - Synthetic construct Homo sapiens gateway clone IMAGE:100022509 5' read RC3H2 mRNA.
LF347060 - JP 2014500723-A/154563: Polycomb-Associated Non-Coding RNAs.
BC011688 - Homo sapiens ring finger and CCCH-type zinc finger domains 2, mRNA (cDNA clone IMAGE:4329353), partial cds.
JD285353 - Sequence 266377 from Patent EP1572962.
LF347062 - JP 2014500723-A/154565: Polycomb-Associated Non-Coding RNAs.
DQ581122 - Homo sapiens piRNA piR-49234, complete sequence.
LF347063 - JP 2014500723-A/154566: Polycomb-Associated Non-Coding RNAs.
MA582613 - JP 2018138019-A/154539: Polycomb-Associated Non-Coding RNAs.
MA582614 - JP 2018138019-A/154540: Polycomb-Associated Non-Coding RNAs.
MA582615 - JP 2018138019-A/154541: Polycomb-Associated Non-Coding RNAs.
MA582616 - JP 2018138019-A/154542: Polycomb-Associated Non-Coding RNAs.
MA582617 - JP 2018138019-A/154543: Polycomb-Associated Non-Coding RNAs.
MA582618 - JP 2018138019-A/154544: Polycomb-Associated Non-Coding RNAs.
MA582619 - JP 2018138019-A/154545: Polycomb-Associated Non-Coding RNAs.
MA582620 - JP 2018138019-A/154546: Polycomb-Associated Non-Coding RNAs.
MA582621 - JP 2018138019-A/154547: Polycomb-Associated Non-Coding RNAs.
MA582622 - JP 2018138019-A/154548: Polycomb-Associated Non-Coding RNAs.
MA582623 - JP 2018138019-A/154549: Polycomb-Associated Non-Coding RNAs.
MA582624 - JP 2018138019-A/154550: Polycomb-Associated Non-Coding RNAs.
MA582625 - JP 2018138019-A/154551: Polycomb-Associated Non-Coding RNAs.
MA582626 - JP 2018138019-A/154552: Polycomb-Associated Non-Coding RNAs.
MA582631 - JP 2018138019-A/154557: Polycomb-Associated Non-Coding RNAs.
MA582632 - JP 2018138019-A/154558: Polycomb-Associated Non-Coding RNAs.
MA582633 - JP 2018138019-A/154559: Polycomb-Associated Non-Coding RNAs.
MA582636 - JP 2018138019-A/154562: Polycomb-Associated Non-Coding RNAs.
MA582637 - JP 2018138019-A/154563: Polycomb-Associated Non-Coding RNAs.
MA582639 - JP 2018138019-A/154565: Polycomb-Associated Non-Coding RNAs.
MA582640 - JP 2018138019-A/154566: Polycomb-Associated Non-Coding RNAs.
MA441256 - JP 2018138019-A/13182: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000357244.1, ENST00000357244.2, ENST00000357244.3, ENST00000357244.4, ENST00000357244.5, ENST00000357244.6, MNAB, NM_001354482, Q4VXB1, Q5JPD7, Q86ST6, Q8N3D6, Q96F27, Q9H5J2, Q9HBD1, Q9HBD2, Q9NWN9, Q9NXE1, RC3H2_HUMAN, RNF164, uc317zyl.1, uc317zyl.2
UCSC ID: ENST00000357244.7_8
RefSeq Accession: NM_001100588.3
Protein: Q9HBD1 (aka RC3H2_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.