Human Gene RCN2 (ENST00000394885.8_7) from GENCODE V47lift37
  Description: reticulocalbin 2, transcript variant 1 (from RefSeq NM_002902.3)
Gencode Transcript: ENST00000394885.8_7
Gencode Gene: ENSG00000117906.14_12
Transcript (Including UTRs)
   Position: hg19 chr15:77,224,090-77,246,734 Size: 22,645 Total Exon Count: 7 Strand: +
Coding Region
   Position: hg19 chr15:77,224,183-77,241,563 Size: 17,381 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr15:77,224,090-77,246,734)mRNA (may differ from genome)Protein (317 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: RCN2_HUMAN
DESCRIPTION: RecName: Full=Reticulocalbin-2; AltName: Full=Calcium-binding protein ERC-55; AltName: Full=E6-binding protein; Short=E6BP; Flags: Precursor;
FUNCTION: Not known. Binds calcium.
SUBCELLULAR LOCATION: Endoplasmic reticulum lumen.
TISSUE SPECIFICITY: Ubiquitous.
SIMILARITY: Belongs to the CREC family.
SIMILARITY: Contains 6 EF-hand domains.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: RCN2
Diseases sorted by gene-association score: bardet-biedl syndrome (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 48.34 RPKM in Testis
Total median expression: 1005.29 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -40.0093-0.430 Picture PostScript Text
3' UTR -1396.675171-0.270 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011992 - EF-hand-like_dom
IPR018247 - EF_Hand_1_Ca_BS
IPR018249 - EF_HAND_2
IPR002048 - EF_hand_Ca-bd

Pfam Domains:
PF13202 - EF hand

SCOP Domains:
47473 - EF-hand

ModBase Predicted Comparative 3D Structure on Q14257
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details Gene Details  
Gene SorterGene Sorter Gene Sorter  
 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0046872 metal ion binding

Cellular Component:
GO:0005730 nucleolus
GO:0005783 endoplasmic reticulum
GO:0005788 endoplasmic reticulum lumen


-  Descriptions from all associated GenBank mRNAs
  LF208503 - JP 2014500723-A/16006: Polycomb-Associated Non-Coding RNAs.
AK313833 - Homo sapiens cDNA, FLJ94458, Homo sapiens reticulocalbin 2, EF-hand calcium binding domain(RCN2), mRNA.
X78669 - H.sapiens ERC-55 mRNA.
BC004892 - Homo sapiens reticulocalbin 2, EF-hand calcium binding domain, mRNA (cDNA clone MGC:1650 IMAGE:3505241), complete cds.
LF377151 - JP 2014500723-A/184654: Polycomb-Associated Non-Coding RNAs.
CU678788 - Synthetic construct Homo sapiens gateway clone IMAGE:100023417 5' read RCN2 mRNA.
KJ905306 - Synthetic construct Homo sapiens clone ccsbBroadEn_14826 RCN2 gene, encodes complete protein.
BT009790 - Homo sapiens reticulocalbin 2, EF-hand calcium binding domain mRNA, complete cds.
HQ448215 - Synthetic construct Homo sapiens clone IMAGE:100071614; CCSB003509_03 reticulocalbin 2, EF-hand calcium binding domain (RCN2) gene, encodes complete protein.
LF377153 - JP 2014500723-A/184656: Polycomb-Associated Non-Coding RNAs.
LF377154 - JP 2014500723-A/184657: Polycomb-Associated Non-Coding RNAs.
AL110102 - Homo sapiens EST from clone 43449, 5' end.
LF377157 - JP 2014500723-A/184660: Polycomb-Associated Non-Coding RNAs.
AK126522 - Homo sapiens cDNA FLJ44558 fis, clone UTERU3008280.
LF377160 - JP 2014500723-A/184663: Polycomb-Associated Non-Coding RNAs.
LF377163 - JP 2014500723-A/184666: Polycomb-Associated Non-Coding RNAs.
LF377164 - JP 2014500723-A/184667: Polycomb-Associated Non-Coding RNAs.
LF377166 - JP 2014500723-A/184669: Polycomb-Associated Non-Coding RNAs.
LF377167 - JP 2014500723-A/184670: Polycomb-Associated Non-Coding RNAs.
LF377168 - JP 2014500723-A/184671: Polycomb-Associated Non-Coding RNAs.
JD025372 - Sequence 6396 from Patent EP1572962.
JD028262 - Sequence 9286 from Patent EP1572962.
JD289805 - Sequence 270829 from Patent EP1572962.
LF377169 - JP 2014500723-A/184672: Polycomb-Associated Non-Coding RNAs.
JD023288 - Sequence 4312 from Patent EP1572962.
JD035841 - Sequence 16865 from Patent EP1572962.
JD415153 - Sequence 396177 from Patent EP1572962.
JD554494 - Sequence 535518 from Patent EP1572962.
JD275476 - Sequence 256500 from Patent EP1572962.
JD342314 - Sequence 323338 from Patent EP1572962.
JD256536 - Sequence 237560 from Patent EP1572962.
JD476719 - Sequence 457743 from Patent EP1572962.
JD311741 - Sequence 292765 from Patent EP1572962.
JD081536 - Sequence 62560 from Patent EP1572962.
JD101453 - Sequence 82477 from Patent EP1572962.
JD516589 - Sequence 497613 from Patent EP1572962.
MA444080 - JP 2018138019-A/16006: Polycomb-Associated Non-Coding RNAs.
MA612728 - JP 2018138019-A/184654: Polycomb-Associated Non-Coding RNAs.
MA612730 - JP 2018138019-A/184656: Polycomb-Associated Non-Coding RNAs.
MA612731 - JP 2018138019-A/184657: Polycomb-Associated Non-Coding RNAs.
MA612734 - JP 2018138019-A/184660: Polycomb-Associated Non-Coding RNAs.
MA612737 - JP 2018138019-A/184663: Polycomb-Associated Non-Coding RNAs.
MA612740 - JP 2018138019-A/184666: Polycomb-Associated Non-Coding RNAs.
MA612741 - JP 2018138019-A/184667: Polycomb-Associated Non-Coding RNAs.
MA612743 - JP 2018138019-A/184669: Polycomb-Associated Non-Coding RNAs.
MA612744 - JP 2018138019-A/184670: Polycomb-Associated Non-Coding RNAs.
MA612745 - JP 2018138019-A/184671: Polycomb-Associated Non-Coding RNAs.
MA612746 - JP 2018138019-A/184672: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: A8MTG6, ENST00000394885.1, ENST00000394885.2, ENST00000394885.3, ENST00000394885.4, ENST00000394885.5, ENST00000394885.6, ENST00000394885.7, ERC55, F8WCY5, NM_002902, Q14257, Q53XN8, RCN2_HUMAN, uc318wzk.1, uc318wzk.2
UCSC ID: ENST00000394885.8_7
RefSeq Accession: NM_002902.3
Protein: Q14257 (aka RCN2_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.