Human Gene RCOR3 (ENST00000419091.7_8) from GENCODE V47lift37
  Description: REST corepressor 3, transcript variant 8 (from RefSeq NR_146433.2)
Gencode Transcript: ENST00000419091.7_8
Gencode Gene: ENSG00000117625.14_17
Transcript (Including UTRs)
   Position: hg19 chr1:211,432,708-211,489,727 Size: 57,020 Total Exon Count: 12 Strand: +
Coding Region
   Position: hg19 chr1:211,432,903-211,487,110 Size: 54,208 Coding Exon Count: 12 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:211,432,708-211,489,727)mRNA (may differ from genome)Protein (553 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: RCOR3_HUMAN
DESCRIPTION: RecName: Full=REST corepressor 3;
FUNCTION: May act as a component of a corepressor complex that represses transcription (Potential).
INTERACTION: Q14687:GSE1; NbExp=3; IntAct=EBI-743428, EBI-372619; P19012:KRT15; NbExp=2; IntAct=EBI-743428, EBI-739566;
SUBCELLULAR LOCATION: Nucleus (By similarity).
SIMILARITY: Belongs to the CoREST family.
SIMILARITY: Contains 1 ELM2 domain.
SIMILARITY: Contains 2 SANT domains.
SEQUENCE CAUTION: Sequence=BAA92581.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 21.03 RPKM in Testis
Total median expression: 492.92 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -49.90195-0.256 Picture PostScript Text
3' UTR -572.602617-0.219 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000949 - ELM2_dom
IPR009057 - Homeodomain-like
IPR001005 - SANT/Myb
IPR017884 - SANT_dom

Pfam Domains:
PF00249 - Myb-like DNA-binding domain
PF01448 - ELM2 domain

SCOP Domains:
46689 - Homeodomain-like

ModBase Predicted Comparative 3D Structure on Q9P2K3
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0044212 transcription regulatory region DNA binding

Biological Process:
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated

Cellular Component:
GO:0005634 nucleus
GO:0005667 transcription factor complex
GO:0017053 transcriptional repressor complex


-  Descriptions from all associated GenBank mRNAs
  AK131312 - Homo sapiens cDNA FLJ16298 fis, clone PERIC2007068, highly similar to REST corepressor 3.
AK300942 - Homo sapiens cDNA FLJ59439 complete cds, highly similar to REST corepressor 3.
JD406337 - Sequence 387361 from Patent EP1572962.
AK302664 - Homo sapiens cDNA FLJ56809 complete cds, highly similar to REST corepressor 3.
BC031608 - Homo sapiens REST corepressor 3, mRNA (cDNA clone MGC:34298 IMAGE:5174915), complete cds.
CU689198 - Synthetic construct Homo sapiens gateway clone IMAGE:100018289 5' read RCOR3 mRNA.
KJ899185 - Synthetic construct Homo sapiens clone ccsbBroadEn_08579 RCOR3 gene, encodes complete protein.
AK001738 - Homo sapiens cDNA FLJ10876 fis, clone NT2RP4001838, weakly similar to Homo sapiens CoREST protein mRNA.
AB037764 - Homo sapiens KIAA1343 mRNA for KIAA1343 protein.
AB463216 - Synthetic construct DNA, clone: pF1KA1343, Homo sapiens RCOR3 gene for REST corepressor 3, without stop codon, in Flexi system.
AK125810 - Homo sapiens cDNA FLJ43822 fis, clone TESTI4002319.
AK311644 - Homo sapiens cDNA, FLJ18686.
JD249286 - Sequence 230310 from Patent EP1572962.
JD501785 - Sequence 482809 from Patent EP1572962.
JD081106 - Sequence 62130 from Patent EP1572962.
JD091778 - Sequence 72802 from Patent EP1572962.
AK057001 - Homo sapiens cDNA FLJ32439 fis, clone SKMUS2001412.

-  Other Names for This Gene
  Alternate Gene Symbols: B3KYA2, B4DYY7, ENST00000419091.1, ENST00000419091.2, ENST00000419091.3, ENST00000419091.4, ENST00000419091.5, ENST00000419091.6, KIAA1343, NR_146433, Q5VT47, Q7L9I5, Q8N5U3, Q9NV83, Q9P2K3, RCOR3_HUMAN, uc319oqx.1, uc319oqx.2
UCSC ID: ENST00000419091.7_8
RefSeq Accession: NM_001136223.3
Protein: Q9P2K3 (aka RCOR3_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.