Human Gene RCSD1 (ENST00000367854.8_8) from GENCODE V47lift37
  Description: RCSD domain containing 1, transcript variant 1 (from RefSeq NM_052862.4)
Gencode Transcript: ENST00000367854.8_8
Gencode Gene: ENSG00000198771.11_10
Transcript (Including UTRs)
   Position: hg19 chr1:167,599,469-167,677,933 Size: 78,465 Total Exon Count: 7 Strand: +
Coding Region
   Position: hg19 chr1:167,599,661-167,673,933 Size: 74,273 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:167,599,469-167,677,933)mRNA (may differ from genome)Protein (416 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: CPZIP_HUMAN
DESCRIPTION: RecName: Full=CapZ-interacting protein; AltName: Full=Protein kinase substrate CapZIP; AltName: Full=RCSD domain-containing protein 1;
FUNCTION: Stress-induced phosphorylation of CAPZIP may regulate the ability of F-actin-capping protein to remodel actin filament assembly.
SUBUNIT: Interacts with CAPZA2 and CAPZB.
TISSUE SPECIFICITY: Highly expressed in skeletal muscle and more weakly in cardiac muscle. Also expressed in several lymphoid organs, including spleen, thymus, peripheral blood leukocytes, lymph node and bone marrow.
PTM: Dephosphorylation results in its dissociation from CAPZA2.
SIMILARITY: Contains 1 RCSD domain.
SEQUENCE CAUTION: Sequence=CAB70910.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 26.09 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 181.04 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -98.40192-0.512 Picture PostScript Text
3' UTR -1105.804000-0.276 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007850 - RCSD

Pfam Domains:
PF05177 - RCSD region
PF15255 - WASH complex subunit CAP-Z interacting, central region

ModBase Predicted Comparative 3D Structure on Q6JBY9
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0051015 actin filament binding

Biological Process:
GO:0003009 skeletal muscle contraction
GO:0071474 cellular hyperosmotic response

Cellular Component:
GO:0005884 actin filament


-  Descriptions from all associated GenBank mRNAs
  AF545852 - Homo sapiens hypothetical protein mRNA, complete cds.
AL137762 - Novel human gene mapping to chomosome 1.
BC101536 - Homo sapiens RCSD domain containing 1, mRNA (cDNA clone MGC:126585 IMAGE:8069042), complete cds.
BC101562 - Homo sapiens RCSD domain containing 1, mRNA (cDNA clone MGC:126611 IMAGE:8069068), complete cds.
BC143428 - Homo sapiens cDNA clone MGC:176953 IMAGE:9051936, complete cds.
AK130798 - Homo sapiens cDNA FLJ27288 fis, clone TMS01856.
JD037488 - Sequence 18512 from Patent EP1572962.
KJ895178 - Synthetic construct Homo sapiens clone ccsbBroadEn_04572 RCSD1 gene, encodes complete protein.
AY530954 - Homo sapiens protein kinase substrate CapZIP mRNA, complete cds.
AL833211 - Homo sapiens mRNA; cDNA DKFZp667N096 (from clone DKFZp667N096).
AK025425 - Homo sapiens cDNA: FLJ21772 fis, clone COLF7808.
BC072399 - Homo sapiens RCSD domain containing 1, mRNA (cDNA clone IMAGE:5786871), partial cds.
BC098426 - Homo sapiens RCSD domain containing 1, mRNA (cDNA clone IMAGE:5485290), partial cds.
BC013186 - Homo sapiens RCSD domain containing 1, mRNA (cDNA clone IMAGE:4339483), complete cds.
AK124221 - Homo sapiens cDNA FLJ42227 fis, clone THYMU2041007.
JD314334 - Sequence 295358 from Patent EP1572962.
JD113996 - Sequence 95020 from Patent EP1572962.
JD559476 - Sequence 540500 from Patent EP1572962.
JD052482 - Sequence 33506 from Patent EP1572962.
JD186177 - Sequence 167201 from Patent EP1572962.
JD186388 - Sequence 167412 from Patent EP1572962.
JD046901 - Sequence 27925 from Patent EP1572962.
JD206091 - Sequence 187115 from Patent EP1572962.
JD535220 - Sequence 516244 from Patent EP1572962.
JD165739 - Sequence 146763 from Patent EP1572962.
JD295111 - Sequence 276135 from Patent EP1572962.
JD085432 - Sequence 66456 from Patent EP1572962.
JD049479 - Sequence 30503 from Patent EP1572962.
JD152183 - Sequence 133207 from Patent EP1572962.
JD152184 - Sequence 133208 from Patent EP1572962.
JD520264 - Sequence 501288 from Patent EP1572962.
JD393280 - Sequence 374304 from Patent EP1572962.
JD202425 - Sequence 183449 from Patent EP1572962.
JD317459 - Sequence 298483 from Patent EP1572962.
JD039512 - Sequence 20536 from Patent EP1572962.
JD565857 - Sequence 546881 from Patent EP1572962.
JD491076 - Sequence 472100 from Patent EP1572962.
JD183697 - Sequence 164721 from Patent EP1572962.
JD327341 - Sequence 308365 from Patent EP1572962.
JD553302 - Sequence 534326 from Patent EP1572962.
JD082115 - Sequence 63139 from Patent EP1572962.
U09197 - Human 5.5 kb mRNA upregulated in retinoic acid treated HL-60 neutrophilic cells.
JD274533 - Sequence 255557 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: B1AK48, CAPZIP, CPZIP_HUMAN, ENST00000367854.1, ENST00000367854.2, ENST00000367854.3, ENST00000367854.4, ENST00000367854.5, ENST00000367854.6, ENST00000367854.7, NM_052862, Q4G0E7, Q6IN93, Q6JBY9, Q8IZM2, Q96DX0, Q9NST4, uc318ggi.1, uc318ggi.2
UCSC ID: ENST00000367854.8_8
RefSeq Accession: NM_052862.4
Protein: Q6JBY9 (aka CPZIP_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.