ID:REL_HUMAN DESCRIPTION: RecName: Full=Proto-oncogene c-Rel; FUNCTION: Proto-oncogene that may play a role in differentiation and lymphopoiesis. NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF- kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF- kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. The NF-kappa-B heterodimer RELA/p65-c-Rel is a transcriptional activator. SUBUNIT: Component of the NF-kappa-B p65-c-Rel complex. Component of the NF-kappa-B p50-c-Rel complex. Component of the NF-kappa-B p52-c-Rel complex. Homodimer; component of the NF-kappa-B c-Rel-c- Rel complex (By similarity). Interacts with NKIRAS1. Interacts with NFKBIB (By similarity). Interacts with NFKBIE. INTERACTION: Q8N668:COMMD1; NbExp=3; IntAct=EBI-307352, EBI-1550112; SUBCELLULAR LOCATION: Nucleus (By similarity). SIMILARITY: Contains 1 RHD (Rel-like) domain. WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/RELID322.html";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
SCOP Domains: 81296 - E set domains 49417 - p53-like transcription factors
ModBase Predicted Comparative 3D Structure on Q04864
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AK303926 - Homo sapiens cDNA FLJ59223 complete cds, highly similar to C-Rel proto-oncogene protein. BC051005 - Homo sapiens v-rel reticuloendotheliosis viral oncogene homolog (avian), mRNA (cDNA clone IMAGE:6304569), partial cds. BC143885 - Homo sapiens v-rel reticuloendotheliosis viral oncogene homolog (avian), mRNA (cDNA clone MGC:177418 IMAGE:9052401), complete cds. BC117191 - Homo sapiens v-rel reticuloendotheliosis viral oncogene homolog (avian), mRNA (cDNA clone MGC:150800 IMAGE:40125742), complete cds. JD141321 - Sequence 122345 from Patent EP1572962. X75042 - H.sapiens rel proto-oncogene mRNA. JD036829 - Sequence 17853 from Patent EP1572962. JD336716 - Sequence 317740 from Patent EP1572962. JD186462 - Sequence 167486 from Patent EP1572962. JD078659 - Sequence 59683 from Patent EP1572962. JD059261 - Sequence 40285 from Patent EP1572962. JD420643 - Sequence 401667 from Patent EP1572962. AB464350 - Synthetic construct DNA, clone: pF1KB7844, Homo sapiens REL gene for v-rel reticuloendotheliosis viral oncogene homolog, without stop codon, in Flexi system. HQ258627 - Synthetic construct Homo sapiens clone IMAGE:100073181 Unknown protein gene, encodes complete protein. KJ901700 - Synthetic construct Homo sapiens clone ccsbBroadEn_11094 REL gene, encodes complete protein. AK123369 - Homo sapiens cDNA FLJ41375 fis, clone BRCAN2007700. LF213595 - JP 2014500723-A/21098: Polycomb-Associated Non-Coding RNAs. LF213593 - JP 2014500723-A/21096: Polycomb-Associated Non-Coding RNAs. MA449172 - JP 2018138019-A/21098: Polycomb-Associated Non-Coding RNAs. MA449170 - JP 2018138019-A/21096: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q04864 (Reactome details) participates in the following event(s):
R-HSA-1168638 Activated IKK phosphorylates I-kappaB R-HSA-1168642 SCF with beta-TrCP1 or beta-TrCP2 binds NF-kappaB:phospho-IkB R-HSA-1169091 Activation of NF-kappaB in B cells R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR) R-HSA-983705 Signaling by the B Cell Receptor (BCR) R-HSA-1280218 Adaptive Immune System R-HSA-168256 Immune System
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
