ID:RENBP_HUMAN DESCRIPTION: RecName: Full=N-acylglucosamine 2-epimerase; Short=AGE; EC=5.1.3.8; AltName: Full=GlcNAc 2-epimerase; AltName: Full=N-acetyl-D-glucosamine 2-epimerase; AltName: Full=Renin-binding protein; Short=RnBP; FUNCTION: Catalyzes the interconversion of N-acetylglucosamine to N-acetylmannosamine. Binds to renin forming a protein complex called high molecular weight (HMW) renin and inhibits renin activity. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway: although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded. CATALYTIC ACTIVITY: N-acyl-D-glucosamine = N-acyl-D-mannosamine. PATHWAY: Amino-sugar metabolism; N-acetylneuraminate degradation. SUBUNIT: Homodimer. SIMILARITY: Belongs to the N-acylglucosamine 2-epimerase family. CAUTION: It is uncertain whether Met-1 or Met-11 is the initiator. SEQUENCE CAUTION: Sequence=AAH15558.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAA01082.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAA01082.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P51606
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006044 N-acetylglucosamine metabolic process GO:0006048 UDP-N-acetylglucosamine biosynthetic process GO:0006051 N-acetylmannosamine metabolic process GO:0008217 regulation of blood pressure GO:0010951 negative regulation of endopeptidase activity GO:0019262 N-acetylneuraminate catabolic process GO:0043086 negative regulation of catalytic activity
Protein P51606 (Reactome details) participates in the following event(s):
R-HSA-6803761 RENBP isomerises ManNAc, ManNGc to GlcNAc, GlcNGc R-HSA-446210 Synthesis of UDP-N-acetyl-glucosamine R-HSA-446219 Synthesis of substrates in N-glycan biosythesis R-HSA-446193 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446203 Asparagine N-linked glycosylation R-HSA-597592 Post-translational protein modification R-HSA-392499 Metabolism of proteins
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
