ID:RERE_HUMAN DESCRIPTION: RecName: Full=Arginine-glutamic acid dipeptide repeats protein; AltName: Full=Atrophin-1-like protein; AltName: Full=Atrophin-1-related protein; FUNCTION: Plays a role as a transcriptional repressor during development. May play a role in the control of cell survival. Overexpression of RERE recruits BAX to the nucleus particularly to POD and triggers caspase-3 activation, leading to cell death. SUBUNIT: Interacts with HDAC1 (By similarity). Interacts with ATN1. Interaction with ATN1 is improved when the poly-Gln region of ATN1 is extended. Interacts with FAT1. INTERACTION: P54259:ATN1; NbExp=3; IntAct=EBI-948076, EBI-945980; SUBCELLULAR LOCATION: Nucleus. Note=Localized in nuclear bodies of variables size. Colocalized with PML and BAX in nuclear PODs. TISSUE SPECIFICITY: Widely expressed. Expressed in tumor cell lines. DOMAIN: The interaction with ATN1 is mediated by the coiled coil domain. DISEASE: Note=A chromosomal aberration involving RERE is found in the neuroblastoma cell line. Translocation t(1;15)(p36.2;q24). SIMILARITY: Contains 1 BAH domain. SIMILARITY: Contains 1 ELM2 domain. SIMILARITY: Contains 1 GATA-type zinc finger. SIMILARITY: Contains 1 SANT domain. SEQUENCE CAUTION: Sequence=AAC31120.1; Type=Frameshift; Positions=588, 596; Sequence=AAD27584.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9P2R6
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0001105 RNA polymerase II transcription coactivator activity GO:0001106 RNA polymerase II transcription corepressor activity GO:0003677 DNA binding GO:0003682 chromatin binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005515 protein binding GO:0008267 poly-glutamine tract binding GO:0008270 zinc ion binding GO:0043565 sequence-specific DNA binding GO:0046872 metal ion binding
Biological Process: GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0006338 chromatin remodeling GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0006366 transcription from RNA polymerase II promoter GO:0006607 NLS-bearing protein import into nucleus GO:0007275 multicellular organism development GO:0021549 cerebellum development GO:0021691 cerebellar Purkinje cell layer maturation GO:0021930 cerebellar granule cell precursor proliferation GO:0021942 radial glia guided migration of Purkinje cell GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0048755 branching morphogenesis of a nerve GO:0048813 dendrite morphogenesis GO:1903507 negative regulation of nucleic acid-templated transcription
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
