Human Gene RETN (ENST00000221515.6_4) from GENCODE V47lift37
  Description: resistin, transcript variant 1 (from RefSeq NM_020415.4)
Gencode Transcript: ENST00000221515.6_4
Gencode Gene: ENSG00000104918.8_8
Transcript (Including UTRs)
   Position: hg19 chr19:7,733,935-7,735,341 Size: 1,407 Total Exon Count: 4 Strand: +
Coding Region
   Position: hg19 chr19:7,734,213-7,735,235 Size: 1,023 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:7,733,935-7,735,341)mRNA (may differ from genome)Protein (108 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MalacardsMGIOMIMPubMedReactomeUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: RETN_HUMAN
DESCRIPTION: RecName: Full=Resistin; AltName: Full=Adipose tissue-specific secretory factor; Short=ADSF; AltName: Full=C/EBP-epsilon-regulated myeloid-specific secreted cysteine-rich protein; AltName: Full=Cysteine-rich secreted protein A12-alpha-like 2; AltName: Full=Cysteine-rich secreted protein FIZZ3; Flags: Precursor;
FUNCTION: Hormone that seems to suppress insulin ability to stimulate glucose uptake into adipose cells. Potentially links obesity to diabetes.
SUBUNIT: Homodimer; disulfide-linked (By similarity).
SUBCELLULAR LOCATION: Secreted.
TISSUE SPECIFICITY: Expressed only in fatty tissues.
SIMILARITY: Belongs to the resistin/FIZZ family.
WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/retn/";

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: RETN
Diseases sorted by gene-association score: diabetes mellitus, noninsulin-dependent* (158), acquired generalized lipodystrophy (27), glucose intolerance (16), progesterone-receptor negative breast cancer (15), gestational diabetes (11), obesity (11), nonalcoholic steatohepatitis (8), morbid obesity (8), anorexia nervosa (8), idiopathic recurrent pericarditis (7), uremia (6), multiple symmetrical lipomatosis (5), coronary artery aneurysm (5), overnutrition (5), coronary artery disease (5), liver cirrhosis (3), diabetes mellitus, insulin-dependent (3), vascular disease (2), acquired metabolic disease (2), myocardial infarction (1), glucose metabolism disease (1), hypertension, essential (1)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 55.12 RPKM in Whole Blood
Total median expression: 95.92 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -25.6083-0.308 Picture PostScript Text
3' UTR -35.80106-0.338 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR009714 - Resistin

Pfam Domains:
PF06954 - Resistin

SCOP Domains:
111423 - Resistin

Protein Data Bank (PDB) 3-D Structure
MuPIT help
1LV6 - Model


ModBase Predicted Comparative 3D Structure on Q9HD89
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005179 hormone activity

Biological Process:
GO:0007568 aging
GO:0008150 biological_process
GO:0009612 response to mechanical stimulus
GO:0010469 regulation of receptor activity
GO:0032868 response to insulin
GO:0043312 neutrophil degranulation
GO:0045444 fat cell differentiation
GO:0050806 positive regulation of synaptic transmission
GO:2000252 negative regulation of feeding behavior
GO:2000872 positive regulation of progesterone secretion

Cellular Component:
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0035578 azurophil granule lumen
GO:0035580 specific granule lumen
GO:0070062 extracellular exosome


-  Descriptions from all associated GenBank mRNAs
  BC069302 - Homo sapiens resistin, mRNA (cDNA clone MGC:97409 IMAGE:7262685), complete cds.
AF290874 - Homo sapiens cysteine-rich secreted A12-alpha-like protein 2 mRNA, complete cds.
AF323081 - Homo sapiens resistin mRNA, complete cds.
AY207314 - Homo sapiens resistin (FIZZ3) mRNA, complete cds.
BC101560 - Homo sapiens resistin, mRNA (cDNA clone MGC:126609 IMAGE:8069066), complete cds.
BC101554 - Homo sapiens resistin, mRNA (cDNA clone MGC:126603 IMAGE:8069060), complete cds.
AF205952 - Homo sapiens cysteine-rich secreted protein (FIZZ3) mRNA, complete cds.
AY359066 - Homo sapiens clone DNA65351 FIZZ-3 (UNQ407) mRNA, complete cds.
HQ448408 - Synthetic construct Homo sapiens clone IMAGE:100071835; CCSB014058_01 resistin (RETN) gene, encodes complete protein.
KJ894348 - Synthetic construct Homo sapiens clone ccsbBroadEn_03742 RETN gene, encodes complete protein.
AB111910 - Homo sapiens RETN mRNA for resistin delta2, complete cds.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_vobesityPathway - Visceral Fat Deposits and the Metabolic Syndrome

Reactome (by CSHL, EBI, and GO)

Protein Q9HD89 (Reactome details) participates in the following event(s):

R-HSA-6798749 Exocytosis of specific granule lumen proteins
R-HSA-6798751 Exocytosis of azurophil granule lumen proteins
R-HSA-6798695 Neutrophil degranulation
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System

-  Other Names for This Gene
  Alternate Gene Symbols: D6W649, ENST00000221515.1, ENST00000221515.2, ENST00000221515.3, ENST00000221515.4, ENST00000221515.5, FIZZ3, HXCP1, NM_020415, Q540D9, Q76B53, Q9HD89, RETN_HUMAN, RSTN, uc317dbr.1, uc317dbr.2, UNQ407/PRO1199
UCSC ID: ENST00000221515.6_4
RefSeq Accession: NM_020415.4
Protein: Q9HD89 (aka RETN_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.