ID:RFC5_HUMAN DESCRIPTION: RecName: Full=Replication factor C subunit 5; AltName: Full=Activator 1 36 kDa subunit; Short=A1 36 kDa subunit; AltName: Full=Activator 1 subunit 5; AltName: Full=Replication factor C 36 kDa subunit; Short=RF-C 36 kDa subunit; Short=RFC36; FUNCTION: The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. SUBUNIT: Heterotetramer of subunits RFC2, RFC3, RFC4 and RFC5 that can form a complex either with RFC1 or with RAD17. The former interacts with PCNA in the presence of ATP, while the latter has ATPase activity but is not stimulated by PCNA. INTERACTION: P35249:RFC4; NbExp=6; IntAct=EBI-712376, EBI-476655; SUBCELLULAR LOCATION: Nucleus (Probable). SIMILARITY: Belongs to the activator 1 small subunits family. WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/rfc5/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P40937
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AK291107 - Homo sapiens cDNA FLJ77120 complete cds, highly similar to Homo sapiens replication factor C (activator 1) 5, 36.5kDa (RFC5), transcript variant 2, mRNA. AK094575 - Homo sapiens cDNA FLJ37256 fis, clone BRAMY2009612, highly similar to Replication factor C subunit 5. AK290685 - Homo sapiens cDNA FLJ76127 complete cds, highly similar to Homo sapiens replication factor C (activator 1) 5, 36.5kDa (RFC5), transcript variant 1, mRNA. BC001866 - Homo sapiens replication factor C (activator 1) 5, 36.5kDa, mRNA (cDNA clone MGC:1155 IMAGE:3544137), complete cds. BC013961 - Homo sapiens replication factor C (activator 1) 5, 36.5kDa, mRNA (cDNA clone MGC:4451 IMAGE:2960023), complete cds. AB208992 - Homo sapiens mRNA for replication factor C 5 isoform 1 variant protein. BC020440 - Homo sapiens replication factor C (activator 1) 5, 36.5kDa, mRNA (cDNA clone IMAGE:3447174). L07540 - Human replication factor C, 36-kDa subunit mRNA, complete cds. AB464140 - Synthetic construct DNA, clone: pF1KB3490, Homo sapiens RFC5 gene for replication factor C, without stop codon, in Flexi system. CU674898 - Synthetic construct Homo sapiens gateway clone IMAGE:100019008 5' read RFC5 mRNA. HQ447800 - Synthetic construct Homo sapiens clone IMAGE:100071143; CCSB003772_01 replication factor C (activator 1) 5, 36.5kDa (RFC5) gene, encodes complete protein. KJ891997 - Synthetic construct Homo sapiens clone ccsbBroadEn_01391 RFC5 gene, encodes complete protein. CR407651 - Homo sapiens full open reading frame cDNA clone RZPDo834G122D for gene RFC5, replication factor C (activator 1) 5, 36.5kDa complete cds, without stopcodon. JD097060 - Sequence 78084 from Patent EP1572962. JD181705 - Sequence 162729 from Patent EP1572962. JD272570 - Sequence 253594 from Patent EP1572962. JD054711 - Sequence 35735 from Patent EP1572962. JD239668 - Sequence 220692 from Patent EP1572962. JD185834 - Sequence 166858 from Patent EP1572962. JD255634 - Sequence 236658 from Patent EP1572962. JD495623 - Sequence 476647 from Patent EP1572962. JD097988 - Sequence 79012 from Patent EP1572962. JD082313 - Sequence 63337 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein P40937 (Reactome details) participates in the following event(s):
R-HSA-69053 RFC binding displaces Pol Alpha R-HSA-174452 RFC binding displaces Pol Alpha on the C-strand of the telomere R-HSA-5690213 DNA polymerases delta, epsilon or kappa bind the GG-NER site R-HSA-6782211 DNA polymerases delta, epsilon or kappa bind the TC-NER site R-HSA-69068 RFC dissociates after sliding clamp formation R-HSA-174447 RFC dissociates after sliding clamp formation on the C-strand of the telomere R-HSA-176101 Recruitment of Rad17-RFC complex to DNA R-HSA-5685011 ATR activation at DNA DSBs R-HSA-5686657 ERCC1:XPF cleaves flaps generated by SSA R-HSA-5693561 RAD51 binds BRCA2 at resected DNA DSBs R-HSA-69063 Loading of PCNA - Sliding Clamp Formation R-HSA-174439 Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere R-HSA-110364 PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1 R-HSA-5651992 PCNA-containing replication complex binds damaged dsDNA R-HSA-5651809 LIG1, APEX1 and PCNA:POLD,POLE:RPA:RFC dissociate from repaired DNA R-HSA-5653840 POLD,POLE complete replication of damaged DNA after TLS R-HSA-5653766 USP10 binds monoUb:K164,ISG:K164,ISG:K168-PCNA R-HSA-5653754 UBE2L6:TRIM25 ISGylates monoUb:K164-PCNA R-HSA-5653780 USP43 binds ISG:K164,ISG:K168-PCNA R-HSA-5653770 USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA R-HSA-5653838 POLD,POLE binds deISGylated PCNA after TLS R-HSA-5653786 USP43 deISGylates ISG:K164,ISG:K168-PCNA R-HSA-5655466 USP1:WDR48 deubiquitinates monoUb:K164-PCNA R-HSA-5690997 Ligation of newly synthesized repair patch to incised DNA in GG-NER R-HSA-6782227 Ligation of newly synthesized repair patch to incised DNA in TC-NER R-HSA-176264 Recruitment of the Rad9-Hus1-Rad1 complex to DNA R-HSA-5684887 Activation of CHEK1 at resected DNA DSBs R-HSA-5684882 CHEK1 is recruited to resected DNA DSBs R-HSA-5685156 ATR phosphorylates RPA2 R-HSA-5693580 Association of RAD52 with the RPA complex at resected DNA DSBs R-HSA-110368 POLD,POLE-mediated DNA strand displacement synthesis R-HSA-110371 LIG1 binds APEX1 and PCNA at SSB R-HSA-110363 FEN1 bound to PCNA and APEX1 cleaves flap ssDNA R-HSA-5651805 LIG1 bound to APEX1 and PCNA ligates SSB R-HSA-5652005 RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA R-HSA-5655481 USP1:WDR48 binds monoUb:K164-PCNA R-HSA-5652009 RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA R-HSA-110307 REV1 binds AP-dsDNA R-HSA-110311 POLZ extends translesion synthesis R-HSA-5653756 TRIM25 binds monoUb:164-PCNA R-HSA-110316 POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template R-HSA-5654986 SPRTN binds monoUb:K164-PCNA associated with POLH R-HSA-110319 Elongation by POLH R-HSA-5654989 SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA R-HSA-5655835 POLK forms a quaternary complex with REV1 and POLZ on damaged DNA template R-HSA-5656105 POLI simultaneously binds REV1 and monoUb:K164-PCNA at damaged DNA R-HSA-110317 Insertion of correct bases opposite the lesion by POLH R-HSA-5690988 3'-incision of DNA by ERCC5 (XPG) in GG-NER R-HSA-5691001 Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER R-HSA-6782224 3' incision by ERCC5 (XPG) in TC-NER R-HSA-6782208 Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER R-HSA-6799332 ATR phosphorylates TP53 R-HSA-5693564 Association of RAD51 with RAD52:DNA double-strand break ends R-HSA-5693593 D-loop extension by DNA polymerases R-HSA-5652151 REV1 recruits POLZ to (AP:Cyt)-DNA Template R-HSA-110308 REV1 inserts dCMP opposite to AP sites in DNA R-HSA-5654985 SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH R-HSA-5655892 POLK incorporates dNMP opposite to damaged DNA base R-HSA-5655965 POLK and POLZ cooperate in elongation of mispaired primer termini R-HSA-5656148 POLI incorporates dNMP opposite to damaged DNA base R-HSA-5656158 POLZ elongates POLI-incorporated dNMP R-HSA-5686642 RAD52 promotes single strand annealing at resected DNA DSBs R-HSA-69091 Polymerase switching R-HSA-174411 Polymerase switching on the C-strand of the telomere R-HSA-5696400 Dual Incision in GG-NER R-HSA-6782135 Dual incision in TC-NER R-HSA-176187 Activation of ATR in response to replication stress R-HSA-5693607 Processing of DNA double-strand break ends R-HSA-5685938 HDR through Single Strand Annealing (SSA) R-HSA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5651801 PCNA-Dependent Long Patch Base Excision Repair R-HSA-110314 Recognition of DNA damage by PCNA-containing replication complex R-HSA-5656169 Termination of translesion DNA synthesis R-HSA-5696397 Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-69109 Leading Strand Synthesis R-HSA-69186 Lagging Strand Synthesis R-HSA-174417 Telomere C-strand (Lagging Strand) Synthesis R-HSA-5696399 Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-6781827 Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-69481 G2/M Checkpoints R-HSA-5693567 HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA) R-HSA-5693579 Homologous DNA Pairing and Strand Exchange R-HSA-110373 Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-73893 DNA Damage Bypass R-HSA-110313 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110312 Translesion synthesis by REV1 R-HSA-110320 Translesion Synthesis by POLH R-HSA-5655862 Translesion synthesis by POLK R-HSA-5656121 Translesion synthesis by POLI R-HSA-69190 DNA strand elongation R-HSA-180786 Extension of Telomeres R-HSA-5696398 Nucleotide Excision Repair R-HSA-69473 G2/M DNA damage checkpoint R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation R-HSA-69620 Cell Cycle Checkpoints R-HSA-5693538 Homology Directed Repair R-HSA-5685942 HDR through Homologous Recombination (HRR) R-HSA-73933 Resolution of Abasic Sites (AP sites) R-HSA-73894 DNA Repair R-HSA-69239 Synthesis of DNA R-HSA-157579 Telomere Maintenance R-HSA-5633007 Regulation of TP53 Activity R-HSA-1640170 Cell Cycle R-HSA-5693532 DNA Double-Strand Break Repair R-HSA-73884 Base Excision Repair R-HSA-69242 S Phase R-HSA-69306 DNA Replication R-HSA-73886 Chromosome Maintenance R-HSA-3700989 Transcriptional Regulation by TP53 R-HSA-69278 Cell Cycle (Mitotic) R-HSA-212436 Generic Transcription Pathway R-HSA-73857 RNA Polymerase II Transcription R-HSA-74160 Gene expression (Transcription)
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
