Human Gene RGL2 (ENST00000425946.1_6) from GENCODE V47lift37
  Description: ral guanine nucleotide dissociation stimulator like 2 (from HGNC RGL2)
Gencode Transcript: ENST00000425946.1_6
Gencode Gene: ENSG00000237441.10_11
Transcript (Including UTRs)
   Position: hg19 chr6:33,264,221-33,266,587 Size: 2,367 Total Exon Count: 4 Strand: -
Coding Region
   Position: hg19 chr6:33,264,221-33,266,387 Size: 2,167 Coding Exon Count: 4 

Page IndexSequence and LinksPrimersMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr6:33,264,221-33,266,587)mRNA (may differ from genome)Protein (146 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblExonPrimerGeneCardsHGNC
MalacardsMGIPubMedUniProtKBWikipedia

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: RGL2
Diseases sorted by gene-association score: tumoral calcinosis, familial, normophosphatemic (10), familial tumoral calcinosis (7), calcinosis (6)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 83.32 RPKM in Spleen
Total median expression: 1448.96 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -35.60200-0.178 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000651 - Ras-like_Gua-exchang_fac_N
IPR008937 - Ras_GEF
IPR023578 - Ras_GEF_dom

Pfam Domains:
PF00618 - RasGEF N-terminal motif

SCOP Domains:
48366 - Ras GEF

ModBase Predicted Comparative 3D Structure on A2AB89
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005085 guanyl-nucleotide exchange factor activity


-  Descriptions from all associated GenBank mRNAs
  BX648015 - Homo sapiens mRNA; cDNA DKFZp686M2259 (from clone DKFZp686M2259).
BC005037 - Homo sapiens ral guanine nucleotide dissociation stimulator-like 2, mRNA (cDNA clone IMAGE:3629760), partial cds.
BC032681 - Homo sapiens ral guanine nucleotide dissociation stimulator-like 2, mRNA (cDNA clone MGC:45263 IMAGE:5585507), complete cds.
AL050259 - Homo sapiens mRNA; cDNA DKFZp564D0782 (from clone DKFZp564D0782).
AK095967 - Homo sapiens cDNA FLJ38648 fis, clone HHDPC2007267, highly similar to RAL GUANINE NUCLEOTIDE DISSOCIATION STIMULATOR-LIKE 2.
AB012295 - Homo sapiens HKE1.5 mRNA for GDS-related protein, complete cds.
BC040989 - Homo sapiens ral guanine nucleotide dissociation stimulator-like 2, mRNA (cDNA clone IMAGE:4816423), complete cds.
AK294442 - Homo sapiens cDNA FLJ53778 complete cds, highly similar to Ral guanine nucleotide dissociation stimulator-like 2.

-  Other Names for This Gene
  Alternate Gene Symbols: A2AB89, A2AB89_HUMAN, BC032681, RGL2 , uc319vcv.1
UCSC ID: ENST00000425946.1_6
RefSeq Accession: NM_004761.5
Protein: A2AB89

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.