Human Gene RGL4 (ENST00000290691.10_5) from GENCODE V47lift37

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Description: ral guanine nucleotide dissociation stimulator like 4, transcript variant 2 (from RefSeq NM_153615.2)
Gencode Transcript: ENST00000290691.10_5
Gencode Gene: ENSG00000159496.15_10
Transcript (Including UTRs)
Position: hg19 chr22:24,033,200-24,041,355 Size: 8,156 Total Exon Count: 11 Strand: +
Coding Region
Position: hg19 chr22:24,034,218-24,041,070 Size: 6,853 Coding Exon Count: 11

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr22:24,033,200-24,041,355)			mRNA (may differ from genome)		Protein (473 aa)
Gene Sorter	Genome Browser	Other Species FASTA	Gene interactions	Table Schema	AlphaFold
BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards	HGNC
MGI	OMIM	PubMed	UniProtKB	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: RGDSR_HUMAN DESCRIPTION: RecName: Full=Ral-GDS-related protein; Short=hRGR; AltName: Full=Ral guanine nucleotide dissociation stimulator-like 4; Short=RalGDS-like 4; SUBCELLULAR LOCATION: Cytoplasmic vesicle (By similarity). SIMILARITY: Contains 1 Ras-GEF domain.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D019327 Copper Sulfate C017947 sodium arsenite

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 17.50 RPKM in Whole Blood Total median expression: 227.98 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-340.40	1018	-0.334	Picture	PostScript	Text
3' UTR	-77.50	285	-0.272	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR008937 - Ras_GEF
IPR023578 - Ras_GEF_dom
IPR001895 - RasGRF_CDC25

Pfam Domains:
PF00617 - RasGEF domain

SCOP Domains:
48366 - Ras GEF

ModBase Predicted Comparative 3D Structure on Q8IZJ4


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0005085 guanyl-nucleotide exchange factor activity Biological Process: GO:0007264 small GTPase mediated signal transduction Cellular Component: GO:0031410 cytoplasmic vesicle

Descriptions from all associated GenBank mRNAs


	KJ904097 - Synthetic construct Homo sapiens clone ccsbBroadEn_13491 RGL4 gene, encodes complete protein. AK131340 - Homo sapiens cDNA FLJ16354 fis, clone TESTI4000319, weakly similar to GUANINE NUCLEOTIDE DISSOCIATION STIMULATOR RALGDS FORM B. AY101396 - Homo sapiens Ral-GDS related protein Rgr mRNA, complete cds. JD470678 - Sequence 451702 from Patent EP1572962. JD417256 - Sequence 398280 from Patent EP1572962. JD478942 - Sequence 459966 from Patent EP1572962. JD305047 - Sequence 286071 from Patent EP1572962. JD358139 - Sequence 339163 from Patent EP1572962. BC101108 - Homo sapiens ral guanine nucleotide dissociation stimulator-like 4, mRNA (cDNA clone MGC:119678 IMAGE:40011557), complete cds. BC101109 - Homo sapiens ral guanine nucleotide dissociation stimulator-like 4, mRNA (cDNA clone MGC:119680 IMAGE:40011564), complete cds. BC101110 - Homo sapiens ral guanine nucleotide dissociation stimulator-like 4, mRNA (cDNA clone IMAGE:40011565), partial cds. JD427141 - Sequence 408165 from Patent EP1572962. JD526030 - Sequence 507054 from Patent EP1572962. JD489302 - Sequence 470326 from Patent EP1572962. JD412114 - Sequence 393138 from Patent EP1572962. JD513100 - Sequence 494124 from Patent EP1572962. JD497122 - Sequence 478146 from Patent EP1572962. JD080999 - Sequence 62023 from Patent EP1572962. JD068134 - Sequence 49158 from Patent EP1572962. JD066133 - Sequence 47157 from Patent EP1572962. BC047947 - Homo sapiens mRNA similar to Ral-GDS related protein Rgr (cDNA clone IMAGE:5750162). JD407791 - Sequence 388815 from Patent EP1572962. JD371382 - Sequence 352406 from Patent EP1572962.

Other Names for This Gene


	Alternate Gene Symbols: ENST00000290691.1, ENST00000290691.2, ENST00000290691.3, ENST00000290691.4, ENST00000290691.5, ENST00000290691.6, ENST00000290691.7, ENST00000290691.8, ENST00000290691.9, NM_153615, Q495L8, Q8IZJ4, RGDSR_HUMAN, RGR, uc317kvw.1, uc317kvw.2 UCSC ID: ENST00000290691.10_5 RefSeq Accession: NM_153615.2 Protein: Q8IZJ4 (aka RGDSR_HUMAN or RGRP_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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