Human Gene RGS1 (ENST00000367459.8_4) from GENCODE V47lift37
  Description: regulator of G protein signaling 1 (from RefSeq NM_002922.4)
Gencode Transcript: ENST00000367459.8_4
Gencode Gene: ENSG00000090104.12_7
Transcript (Including UTRs)
   Position: hg19 chr1:192,544,903-192,549,154 Size: 4,252 Total Exon Count: 5 Strand: +
Coding Region
   Position: hg19 chr1:192,544,923-192,548,452 Size: 3,530 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:192,544,903-192,549,154)mRNA (may differ from genome)Protein (209 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
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WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: RGS1_HUMAN
DESCRIPTION: RecName: Full=Regulator of G-protein signaling 1; Short=RGS1; AltName: Full=B-cell activation protein BL34; AltName: Full=Early response protein 1R20;
FUNCTION: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. This protein may be involved in the regulation of B-cell activation and proliferation.
TISSUE SPECIFICITY: B-cell specific. Expression is relatively low in B-cells and chronic lymphocytic leukemia B-cells; however, in other types of malignant B-cell such as non-Hodgkin lymphoma and hairy cell leukemia, expression is constitutively high.
INDUCTION: In response to several B-cell activation signals.
PTM: Could be phosphorylated. Might be functionally regulated by protein kinase(s).
SIMILARITY: Contains 1 RGS domain.
SEQUENCE CAUTION: Sequence=AAB26289.1; Type=Erroneous initiation; Sequence=AAH15510.1; Type=Erroneous initiation; Sequence=BAG37976.1; Type=Erroneous initiation; Sequence=BAG64242.1; Type=Erroneous initiation; Sequence=CAA51826.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 184.78 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 1006.27 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -2.3020-0.115 Picture PostScript Text
3' UTR -156.40702-0.223 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000342 - Regulat_G_prot_signal
IPR024066 - Regulat_G_prot_signal_dom1
IPR016137 - Regulat_G_prot_signal_superfam

Pfam Domains:
PF00615 - Regulator of G protein signaling domain

SCOP Domains:
48097 - Regulator of G-protein signaling, RGS

Protein Data Bank (PDB) 3-D Structure
MuPIT help
2BV1 - X-ray MuPIT 2GTP - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on Q08116
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0001965 G-protein alpha-subunit binding
GO:0005096 GTPase activator activity
GO:0005516 calmodulin binding

Biological Process:
GO:0006955 immune response
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway
GO:0009968 negative regulation of signal transduction
GO:0043547 positive regulation of GTPase activity
GO:0061737 leukotriene signaling pathway

Cellular Component:
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane


-  Descriptions from all associated GenBank mRNAs
  AK303138 - Homo sapiens cDNA FLJ57687 complete cds, highly similar to Regulator of G-protein signaling 1.
AK315607 - Homo sapiens cDNA, FLJ96688, highly similar to Homo sapiens regulator of G-protein signalling 1 (RGS1), mRNA.
AK093544 - Homo sapiens cDNA FLJ36225 fis, clone THYMU2001007, moderately similar to REGULATOR OF G-PROTEIN SIGNALING 1.
BC015510 - Homo sapiens regulator of G-protein signaling 1, mRNA (cDNA clone MGC:9198 IMAGE:3916789), complete cds.
EU668340 - Homo sapiens epididymis secretory protein Li 87 (HEL-S-87) mRNA, complete cds.
S59049 - BL34=B cell activation gene [human, mRNA, 1398 nt].
X73427 - H.sapiens 1r20 mRNA for alpha helical basic phosphoprotein.
AB590399 - Synthetic construct DNA, clone: pFN21AE1542, Homo sapiens RGS1 gene for regulator of G-protein signaling 1, without stop codon, in Flexi system.
BT006668 - Homo sapiens regulator of G-protein signalling 1 mRNA, complete cds.
DQ890651 - Synthetic construct clone IMAGE:100003281; FLH164791.01X; RZPDo839B12158D regulator of G-protein signalling 1 (RGS1) gene, encodes complete protein.
DQ893831 - Synthetic construct Homo sapiens clone IMAGE:100008291; FLH164787.01L; RZPDo839B12157D regulator of G-protein signalling 1 (RGS1) gene, encodes complete protein.
KJ901705 - Synthetic construct Homo sapiens clone ccsbBroadEn_11099 RGS1 gene, encodes complete protein.
AF493925 - Homo sapiens regulator of G protein signalling 1 (RGS1) mRNA, complete cds.
JD062574 - Sequence 43598 from Patent EP1572962.
JD544906 - Sequence 525930 from Patent EP1572962.
JD265198 - Sequence 246222 from Patent EP1572962.
JD434883 - Sequence 415907 from Patent EP1572962.
JD335867 - Sequence 316891 from Patent EP1572962.
JD075515 - Sequence 56539 from Patent EP1572962.
JD491619 - Sequence 472643 from Patent EP1572962.
JD349751 - Sequence 330775 from Patent EP1572962.
JD529997 - Sequence 511021 from Patent EP1572962.
JD315613 - Sequence 296637 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: 1R20, B2RDM9, B4DZY0, BL34, ENST00000367459.1, ENST00000367459.2, ENST00000367459.3, ENST00000367459.4, ENST00000367459.5, ENST00000367459.6, ENST00000367459.7, IER1, NM_002922, Q07918, Q08116, Q9H1W2, RGS1_HUMAN, uc318fxz.1, uc318fxz.2
UCSC ID: ENST00000367459.8_4
RefSeq Accession: NM_002922.4
Protein: Q08116 (aka RGS1_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.