Human Gene RGS2 (ENST00000235382.7_4) from GENCODE V47lift37
  Description: regulator of G protein signaling 2 (from RefSeq NM_002923.4)
Gencode Transcript: ENST00000235382.7_4
Gencode Gene: ENSG00000116741.8_7
Transcript (Including UTRs)
   Position: hg19 chr1:192,778,169-192,781,405 Size: 3,237 Total Exon Count: 5 Strand: +
Coding Region
   Position: hg19 chr1:192,778,202-192,780,726 Size: 2,525 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:192,778,169-192,781,405)mRNA (may differ from genome)Protein (211 aa)
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UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: RGS2_HUMAN
DESCRIPTION: RecName: Full=Regulator of G-protein signaling 2; Short=RGS2; AltName: Full=Cell growth-inhibiting gene 31 protein; AltName: Full=G0/G1 switch regulatory protein 8;
FUNCTION: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. May play a role in leukemogenesis. Plays a role in negative feedback control pathway for adenylyl cyclase signaling. Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein.
SUBUNIT: Interacts with EIF2B5. Interacts with PRKG1 (isoform alpha).
SUBCELLULAR LOCATION: Isoform 1: Cell membrane. Cytoplasm. Nucleus, nucleolus.
SUBCELLULAR LOCATION: Isoform 2: Cell membrane. Cytoplasm. Nucleus, nucleolus.
SUBCELLULAR LOCATION: Isoform 3: Cell membrane. Cytoplasm. Nucleus, nucleolus.
SUBCELLULAR LOCATION: Isoform 4: Cell membrane. Mitochondrion.
TISSUE SPECIFICITY: Expressed in acute myelogenous leukemia (AML) and in acute lymphoblastic leukemia (ALL).
PTM: Phosphorylated by protein kinase C. Phosphorylation by PRKG1 leads to activation of RGS2 activity.
SIMILARITY: Contains 1 RGS domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: RGS2
Diseases sorted by gene-association score: c5 deficiency (9), generalized anxiety disorder (7), phobic disorder (6), gitelman syndrome (6), agoraphobia (5), anxiety disorder (3)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 233.21 RPKM in Esophagus - Muscularis
Total median expression: 2293.30 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -7.1033-0.215 Picture PostScript Text
3' UTR -167.00679-0.246 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000342 - Regulat_G_prot_signal
IPR024066 - Regulat_G_prot_signal_dom1
IPR016137 - Regulat_G_prot_signal_superfam

Pfam Domains:
PF00615 - Regulator of G protein signaling domain

SCOP Domains:
48097 - Regulator of G-protein signaling, RGS

Protein Data Bank (PDB) 3-D Structure
MuPIT help
2AF0 - X-ray MuPIT 2V4Z - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on P41220
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0001965 G-protein alpha-subunit binding
GO:0005096 GTPase activator activity
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0048487 beta-tubulin binding

Biological Process:
GO:0006417 regulation of translation
GO:0007049 cell cycle
GO:0007283 spermatogenesis
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway
GO:0009968 negative regulation of signal transduction
GO:0010519 negative regulation of phospholipase activity
GO:0010614 negative regulation of cardiac muscle hypertrophy
GO:0031116 positive regulation of microtubule polymerization
GO:0043407 negative regulation of MAP kinase activity
GO:0043547 positive regulation of GTPase activity
GO:0043951 negative regulation of cAMP-mediated signaling
GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway
GO:0050873 brown fat cell differentiation
GO:0055119 relaxation of cardiac muscle
GO:0060087 relaxation of vascular smooth muscle
GO:0060452 positive regulation of cardiac muscle contraction

Cellular Component:
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0009898 cytoplasmic side of plasma membrane
GO:0016020 membrane
GO:0043005 neuron projection


-  Descriptions from all associated GenBank mRNAs
  BC042755 - Homo sapiens regulator of G-protein signaling 2, 24kDa, mRNA (cDNA clone IMAGE:4830785), complete cds.
BC044742 - Homo sapiens regulator of G-protein signaling 2, 24kDa, mRNA (cDNA clone IMAGE:4829698).
AK313668 - Homo sapiens cDNA, FLJ94250, Homo sapiens regulator of G-protein signalling 2, 24kDa (RGS2),mRNA.
L13463 - Human helix-loop-helix basic phosphoprotein (G0S8) mRNA, complete cds.
BC007049 - Homo sapiens regulator of G-protein signaling 2, 24kDa, mRNA (cDNA clone MGC:12460 IMAGE:3681138), complete cds.
AY971351 - Homo sapiens cell growth-inhibiting protein 31 mRNA, complete cds.
JD435121 - Sequence 416145 from Patent EP1572962.
CR457410 - Homo sapiens full open reading frame cDNA clone RZPDo834H0910D for gene RGS2, regulator of G-protein signalling 2, 24kDa; complete cds, incl. stopcodon.
AB528517 - Synthetic construct DNA, clone: pF1KB6947, Homo sapiens RGS2 gene for regulator of G-protein signaling 2, 24kDa, without stop codon, in Flexi system.
BT007065 - Homo sapiens regulator of G-protein signalling 2, 24kDa mRNA, complete cds.
DQ893178 - Synthetic construct clone IMAGE:100005808; FLH194687.01X; RZPDo839D1280D regulator of G-protein signalling 2, 24kDa (RGS2) gene, encodes complete protein.
DQ896478 - Synthetic construct Homo sapiens clone IMAGE:100010938; FLH194683.01L; RZPDo839D1270D regulator of G-protein signalling 2, 24kDa (RGS2) gene, encodes complete protein.
CU675517 - Synthetic construct Homo sapiens gateway clone IMAGE:100016776 5' read RGS2 mRNA.
KJ897467 - Synthetic construct Homo sapiens clone ccsbBroadEn_06861 RGS2 gene, encodes complete protein.
KR710140 - Synthetic construct Homo sapiens clone CCSBHm_00010050 RGS2 (RGS2) mRNA, encodes complete protein.
KR710141 - Synthetic construct Homo sapiens clone CCSBHm_00010051 RGS2 (RGS2) mRNA, encodes complete protein.
KR710142 - Synthetic construct Homo sapiens clone CCSBHm_00010053 RGS2 (RGS2) mRNA, encodes complete protein.
AF493926 - Homo sapiens regulator of G protein signalling 2 (RGS2) mRNA, complete cds.
JD302379 - Sequence 283403 from Patent EP1572962.
JD297909 - Sequence 278933 from Patent EP1572962.
JD037985 - Sequence 19009 from Patent EP1572962.
JD043357 - Sequence 24381 from Patent EP1572962.
JD330178 - Sequence 311202 from Patent EP1572962.
JD174420 - Sequence 155444 from Patent EP1572962.
JD486701 - Sequence 467725 from Patent EP1572962.
JD226083 - Sequence 207107 from Patent EP1572962.
JD435128 - Sequence 416152 from Patent EP1572962.
JD488259 - Sequence 469283 from Patent EP1572962.
JD088686 - Sequence 69710 from Patent EP1572962.
JD502191 - Sequence 483215 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000235382.1, ENST00000235382.2, ENST00000235382.3, ENST00000235382.4, ENST00000235382.5, ENST00000235382.6, G0S8, GIG31, NM_002923, P41220, Q6I9U5, RGS2_HUMAN, uc317eah.1, uc317eah.2
UCSC ID: ENST00000235382.7_4
RefSeq Accession: NM_002923.4
Protein: P41220 (aka RGS2_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.