Human Gene RGS7 (ENST00000440928.6_9) from GENCODE V47lift37
  Description: regulator of G protein signaling 7, transcript variant 14 (from RefSeq NM_001374810.1)
Gencode Transcript: ENST00000440928.6_9
Gencode Gene: ENSG00000182901.18_15
Transcript (Including UTRs)
   Position: hg19 chr1:240,938,814-241,520,505 Size: 581,692 Total Exon Count: 19 Strand: -
Coding Region
   Position: hg19 chr1:240,963,947-241,519,076 Size: 555,130 Coding Exon Count: 17 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:240,938,814-241,520,505)mRNA (may differ from genome)Protein (495 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: Q5T3H5_HUMAN
DESCRIPTION: SubName: Full=Regulator of G-protein signaling 7; SubName: Full=Regulator of G-protein-signaling 7; Flags: Fragment;
SIMILARITY: Contains 1 RGS domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: RGS7
Diseases sorted by gene-association score: uterine benign neoplasm (5), reproductive organ benign neoplasm (4)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 22.46 RPKM in Brain - Frontal Cortex (BA9)
Total median expression: 159.46 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -179.60357-0.503 Picture PostScript Text
3' UTR -132.14706-0.187 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR015898 - G-protein_gamma-like_dom
IPR000342 - Regulat_G_prot_signal
IPR024066 - Regulat_G_prot_signal_dom1
IPR016137 - Regulat_G_prot_signal_superfam

Pfam Domains:
PF00610 - Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)
PF00615 - Regulator of G protein signaling domain
PF00631 - GGL domain
PF18148 - Regulator of G-protein signalling DHEX domain

SCOP Domains:
48670 - Transducin (heterotrimeric G protein), gamma chain
46785 - "Winged helix" DNA-binding domain
48097 - Regulator of G-protein signaling, RGS

ModBase Predicted Comparative 3D Structure on Q5T3H5
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Biological Process:
GO:0007186 G-protein coupled receptor signaling pathway


-  Descriptions from all associated GenBank mRNAs
  AK294354 - Homo sapiens cDNA FLJ61685 complete cds, highly similar to Regulator of G-protein signaling 7.
U32439 - Human regulator of G-protein signaling similarity (RGS7) mRNA, partial cds.
AF090116 - Homo sapiens regulator of G-protein signaling 7 (RGS7) mRNA, complete cds.
BC022009 - Homo sapiens regulator of G-protein signaling 7, mRNA (cDNA clone MGC:26289 IMAGE:4823760), complete cds.
AK294234 - Homo sapiens cDNA FLJ55428 complete cds, highly similar to Regulator of G-protein signaling 7.
AF493930 - Homo sapiens regulator of G protein signalling 7 (RGS7) mRNA, complete cds, alternatively spliced.
AF493931 - Homo sapiens regulator of G protein signalling 7 (RGS7) mRNA, complete cds, alternatively spliced.
AY587875 - Homo sapiens regulator of G-protein signaling RGS7 mRNA, complete cds.
AK314862 - Homo sapiens cDNA, FLJ95761.
DQ890794 - Synthetic construct clone IMAGE:100003424; FLH165988.01X; RZPDo839B0786D regulator of G-protein signalling 7 (RGS7) gene, encodes complete protein.
KJ897469 - Synthetic construct Homo sapiens clone ccsbBroadEn_06863 RGS7 gene, encodes complete protein.
DQ893949 - Synthetic construct Homo sapiens clone IMAGE:100008409; FLH165984.01L; RZPDo839B0785D regulator of G-protein signalling 7 (RGS7) gene, encodes complete protein.
DQ893954 - Synthetic construct Homo sapiens clone IMAGE:100008414; FLH263676.01L; RZPDo839C0185D regulator of G-protein signalling 7 (RGS7) gene, encodes complete protein.
AB527513 - Synthetic construct DNA, clone: pF1KB5852, Homo sapiens RGS7 gene for regulator of G-protein signaling 7, without stop codon, in Flexi system.
CU692446 - Synthetic construct Homo sapiens gateway clone IMAGE:100019632 5' read RGS7 mRNA.
AF090117 - Homo sapiens regulator of G-protein signaling 7b (RGS7) mRNA, partial cds.
JD284113 - Sequence 265137 from Patent EP1572962.
JD046440 - Sequence 27464 from Patent EP1572962.
JD424594 - Sequence 405618 from Patent EP1572962.
JD494000 - Sequence 475024 from Patent EP1572962.
JD550672 - Sequence 531696 from Patent EP1572962.
JD149957 - Sequence 130981 from Patent EP1572962.
JD412574 - Sequence 393598 from Patent EP1572962.
JD174627 - Sequence 155651 from Patent EP1572962.
JD171869 - Sequence 152893 from Patent EP1572962.
JD206794 - Sequence 187818 from Patent EP1572962.
DQ139291 - Homo sapiens regulator of G-protein signaling 7 isoform D (RGS7) mRNA, partial cds, alternatively spliced.
DQ139290 - Homo sapiens regulator of G-protein signaling 7 isoform A (RGS7) mRNA, partial cds, alternatively spliced.
JD503342 - Sequence 484366 from Patent EP1572962.
JD266934 - Sequence 247958 from Patent EP1572962.
JD077113 - Sequence 58137 from Patent EP1572962.
JD458299 - Sequence 439323 from Patent EP1572962.
JD523660 - Sequence 504684 from Patent EP1572962.
JD310655 - Sequence 291679 from Patent EP1572962.
JD406384 - Sequence 387408 from Patent EP1572962.
JD442630 - Sequence 423654 from Patent EP1572962.
JD310573 - Sequence 291597 from Patent EP1572962.
JD226496 - Sequence 207520 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000440928.1, ENST00000440928.2, ENST00000440928.3, ENST00000440928.4, ENST00000440928.5, NM_001374810, Q5T3H5, Q5T3H5_HUMAN, RGS7 , uc320jbf.1, uc320jbf.2
UCSC ID: ENST00000440928.6_9
RefSeq Accession: NM_001364886.1
Protein: Q5T3H5

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.