Human Gene RHOA (ENST00000418115.6_7) from GENCODE V47lift37
  Description: ras homolog family member A, transcript variant 1 (from RefSeq NM_001664.4)
Gencode Transcript: ENST00000418115.6_7
Gencode Gene: ENSG00000067560.14_20
Transcript (Including UTRs)
   Position: hg19 chr3:49,396,578-49,449,409 Size: 52,832 Total Exon Count: 5 Strand: -
Coding Region
   Position: hg19 chr3:49,397,642-49,413,022 Size: 15,381 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr3:49,396,578-49,449,409)mRNA (may differ from genome)Protein (193 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedReactome
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: RHOA_HUMAN
DESCRIPTION: RecName: Full=Transforming protein RhoA; AltName: Full=Rho cDNA clone 12; Short=h12; Flags: Precursor;
FUNCTION: Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disorders. Stimulates PKN2 kinase activity. May be an activator of PLCE1. Activated by ARHGEF2, which promotes the exchange of GDP for GTP. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. The MEMO1-RHOA- DIAPH1 signaling pathway plays an important role in ERBB2- dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization.
COFACTOR: Magnesium.
ENZYME REGULATION: GTP hydrolysis is stimulated by ARHGAP30.
SUBUNIT: Interacts with ARHGEF28 (By similarity). Binds PRKCL1, ROCK1 and ROCK2. Interacts with ARHGEF2, ARHGEF3, NET1 and RTKN. Interacts with PLCE1 and AKAP13. Interacts (in the constitutively activated, GTP-bound form) with DGKQ. Interacts with human respiratory syncytial virus (HRSV) protein F; this interaction facilitates virus-induced syncytium formation. Interacts with GNB2L1/RACK1; enhances RHOA activation. Interacts with PKP4; the interaction is detected at the midbody. Interacts (GTP-bound form preferentially) with PKN2; the interaction stimulates autophosphorylation and phosphorylation of PKN2.
INTERACTION: Q07960:ARHGAP1; NbExp=2; IntAct=EBI-446668, EBI-602762; P52565:ARHGDIA; NbExp=2; IntAct=EBI-446668, EBI-712693; O15085:ARHGEF11; NbExp=2; IntAct=EBI-446668, EBI-311099; Q969H4:CNKSR1; NbExp=4; IntAct=EBI-446668, EBI-741671; O08808:Diaph1 (xeno); NbExp=3; IntAct=EBI-446668, EBI-1026445; Q6PDM6:Mcf2l (xeno); NbExp=3; IntAct=EBI-446668, EBI-602149; Q9Z0S9:Rabac1 (xeno); NbExp=3; IntAct=EBI-446668, EBI-476965; Q8C6B2:Rtkn (xeno); NbExp=2; IntAct=EBI-446668, EBI-1162441; Q15796:SMAD2; NbExp=2; IntAct=EBI-446668, EBI-1040141;
SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm, cytoskeleton. Cleavage furrow. Cytoplasm, cell cortex. Midbody. Note=Localized to cell-cell contacts in calcium- treated keratinocytes (By similarity). Translocates to the equatorial region before furrow formation in a ECT2-dependent manner. Localizes to the equatorial cell cortex (at the site of the presumptive furrow) in early anaphase in a activated form and in a myosin- and actin-independent manner.
DOMAIN: The basic-rich region is essential for yopT recognition and cleavage.
PTM: Substrate for botulinum ADP-ribosyltransferase.
PTM: Cleaved by yopT protease when the cell is infected by some Yersinia pathogens. This removes the lipid attachment, and leads to its displacement from plasma membrane and to subsequent cytoskeleton cleavage.
PTM: AMPylation at Tyr-34 and Thr-37 are mediated by bacterial enzymes in case of infection by H.somnus and V.parahaemolyticus, respectively. AMPylation occurs in the effector region and leads to inactivation of the GTPase activity by preventing the interaction with downstream effectors, thereby inhibiting actin assembly in infected cells. It is unclear whether some human enzyme mediates AMPylation; FICD has such ability in vitro but additional experiments remain to be done to confirm results in vivo.
PTM: Phosphorylation by PRKG1 at Ser-188 inactivates RHOA signaling.
PTM: Ubiquitinated by the BCR(BACURD1) and BCR(BACURD2) E3 ubiquitin ligase complexes, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration.
SIMILARITY: Belongs to the small GTPase superfamily. Rho family.
WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/RHOAID42107ch3p21.html";

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: RHOA
Diseases sorted by gene-association score: colorectal cancer (4), pulmonary hypertension (3), pancreatic cancer (2), gastrointestinal defects and immunodeficiency syndrome (2), breast cancer (2), cervix carcinoma (2), sexual disorder (2), cerebral cavernous malformations-2 (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 339.77 RPKM in Artery - Tibial
Total median expression: 9086.18 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -52.90159-0.333 Picture PostScript Text
3' UTR -267.001064-0.251 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR005225 - Small_GTP-bd_dom
IPR001806 - Small_GTPase
IPR003578 - Small_GTPase_Rho

Pfam Domains:
PF00025 - ADP-ribosylation factor family
PF00071 - Ras family
PF08477 - Ras of Complex, Roc, domain of DAPkinase

SCOP Domains:
51735 - NAD(P)-binding Rossmann-fold domains
52540 - P-loop containing nucleoside triphosphate hydrolases

Protein Data Bank (PDB) 3-D Structure
MuPIT help
1A2B - X-ray MuPIT 1CC0 - X-ray 1CXZ - X-ray MuPIT 1DPF - X-ray MuPIT 1FTN - X-ray MuPIT 1KMQ - X-ray MuPIT 1LB1 - X-ray MuPIT 1OW3 - X-ray MuPIT 1S1C - X-ray MuPIT 1TX4 - X-ray MuPIT 1X86 - X-ray MuPIT 1XCG - X-ray MuPIT 2RGN - X-ray 3KZ1 - X-ray MuPIT 3LW8 - X-ray MuPIT 3LWN - X-ray MuPIT 3LXR - X-ray MuPIT 3MSX - X-ray MuPIT 3T06 - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on P61586
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologGenome Browser
Gene DetailsGene Details Gene DetailsGene DetailsGene Details
Gene SorterGene Sorter Gene SorterGene SorterGene Sorter
 RGDEnsembl WormBaseSGD
     Protein Sequence
     Alignment

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0017022 myosin binding
GO:0019003 GDP binding
GO:0019904 protein domain specific binding
GO:0051022 Rho GDP-dissociation inhibitor binding

Biological Process:
GO:0000902 cell morphogenesis
GO:0001666 response to hypoxia
GO:0001998 angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure
GO:0002363 alpha-beta T cell lineage commitment
GO:0003100 regulation of systemic arterial blood pressure by endothelin
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0007010 cytoskeleton organization
GO:0007049 cell cycle
GO:0007155 cell adhesion
GO:0007160 cell-matrix adhesion
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007264 small GTPase mediated signal transduction
GO:0007266 Rho protein signal transduction
GO:0007519 skeletal muscle tissue development
GO:0008064 regulation of actin polymerization or depolymerization
GO:0009612 response to mechanical stimulus
GO:0009749 response to glucose
GO:0010812 negative regulation of cell-substrate adhesion
GO:0010975 regulation of neuron projection development
GO:0010977 negative regulation of neuron projection development
GO:0016032 viral process
GO:0016477 cell migration
GO:0016579 protein deubiquitination
GO:0021762 substantia nigra development
GO:0021795 cerebral cortex cell migration
GO:0021861 forebrain radial glial cell differentiation
GO:0030036 actin cytoskeleton organization
GO:0030154 cell differentiation
GO:0030307 positive regulation of cell growth
GO:0030334 regulation of cell migration
GO:0030335 positive regulation of cell migration
GO:0030521 androgen receptor signaling pathway
GO:0030838 positive regulation of actin filament polymerization
GO:0031098 stress-activated protein kinase signaling cascade
GO:0031532 actin cytoskeleton reorganization
GO:0032467 positive regulation of cytokinesis
GO:0032956 regulation of actin cytoskeleton organization
GO:0033144 negative regulation of intracellular steroid hormone receptor signaling pathway
GO:0033688 regulation of osteoblast proliferation
GO:0034329 cell junction assembly
GO:0035385 Roundabout signaling pathway
GO:0036089 cleavage furrow formation
GO:0038027 apolipoprotein A-I-mediated signaling pathway
GO:0042476 odontogenesis
GO:0042493 response to drug
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043149 stress fiber assembly
GO:0043200 response to amino acid
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043297 apical junction assembly
GO:0043312 neutrophil degranulation
GO:0043366 beta selection
GO:0043524 negative regulation of neuron apoptotic process
GO:0043525 positive regulation of neuron apoptotic process
GO:0043542 endothelial cell migration
GO:0043931 ossification involved in bone maturation
GO:0044319 wound healing, spreading of cells
GO:0045198 establishment of epithelial cell apical/basal polarity
GO:0045471 response to ethanol
GO:0045665 negative regulation of neuron differentiation
GO:0045666 positive regulation of neuron differentiation
GO:0045727 positive regulation of translation
GO:0045785 positive regulation of cell adhesion
GO:0045792 negative regulation of cell size
GO:0045907 positive regulation of vasoconstriction
GO:0045987 positive regulation of smooth muscle contraction
GO:0046039 GTP metabolic process
GO:0046638 positive regulation of alpha-beta T cell differentiation
GO:0048010 vascular endothelial growth factor receptor signaling pathway
GO:0048013 ephrin receptor signaling pathway
GO:0048015 phosphatidylinositol-mediated signaling
GO:0048812 neuron projection morphogenesis
GO:0050771 negative regulation of axonogenesis
GO:0050772 positive regulation of axonogenesis
GO:0050773 regulation of dendrite development
GO:0050919 negative chemotaxis
GO:0051056 regulation of small GTPase mediated signal transduction
GO:0051301 cell division
GO:0051384 response to glucocorticoid
GO:0051496 positive regulation of stress fiber assembly
GO:0051893 regulation of focal adhesion assembly
GO:0051924 regulation of calcium ion transport
GO:0060071 Wnt signaling pathway, planar cell polarity pathway
GO:0060193 positive regulation of lipase activity
GO:0060548 negative regulation of cell death
GO:0061383 trabecula morphogenesis
GO:0070507 regulation of microtubule cytoskeleton organization
GO:0071222 cellular response to lipopolysaccharide
GO:0071277 cellular response to calcium ion
GO:0071803 positive regulation of podosome assembly
GO:0071902 positive regulation of protein serine/threonine kinase activity
GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis
GO:0090307 mitotic spindle assembly
GO:0090324 negative regulation of oxidative phosphorylation
GO:0097498 endothelial tube lumen extension
GO:1901224 positive regulation of NIK/NF-kappaB signaling
GO:1902766 skeletal muscle satellite cell migration
GO:1903427 negative regulation of reactive oxygen species biosynthetic process
GO:1903673 mitotic cleavage furrow formation
GO:1904695 positive regulation of vascular smooth muscle contraction
GO:1905244 regulation of modification of synaptic structure
GO:1990869 cellular response to chemokine
GO:2000145 regulation of cell motility
GO:2000177 regulation of neural precursor cell proliferation
GO:2000406 positive regulation of T cell migration

Cellular Component:
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005789 endoplasmic reticulum membrane
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0005938 cell cortex
GO:0016020 membrane
GO:0030027 lamellipodium
GO:0030054 cell junction
GO:0030424 axon
GO:0030496 midbody
GO:0030667 secretory granule membrane
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
GO:0031982 vesicle
GO:0032154 cleavage furrow
GO:0032587 ruffle membrane
GO:0042995 cell projection
GO:0043197 dendritic spine
GO:0043296 apical junction complex
GO:0070062 extracellular exosome
GO:0071944 cell periphery
GO:0101003 ficolin-1-rich granule membrane


-  Descriptions from all associated GenBank mRNAs
  L25080 - Homo sapiens GTP-binding protein (rhoA) mRNA, complete cds.
AK222556 - Homo sapiens mRNA for ras homolog gene family, member A variant, clone: adSU01332.
BX647063 - Homo sapiens mRNA; cDNA DKFZp686F10192 (from clone DKFZp686F10192); complete cds.
DI441763 - KR 1020140091683-A/7: METHODS AND COMPOSITIONS FOR NEUROPROTECTION.
HW819142 - JP 2015501634-A/7: METHODS AND COMPOSITIONS FOR NEUROPROTECTION.
JB747466 - Sequence 7 from Patent WO2013067076.
HH837119 - Sequence 46 from Patent EP2231168.
HI214760 - Sequence 46 from Patent EP2076526.
HV601562 - JP 2011500003-A/46: Novel siRNA Structures.
HV856635 - JP 2010507387-A/46: Novel siRNAs and Methods of Use Thereof.
HW061170 - JP 2012529430-A/45: METHODS FOR TREATING CHRONIC KIDNEY DISEASE.
HW165122 - JP 2013102767-A/46: Novel siRNA's and Use Thereof.
HW388680 - JP 2013537404-A/1: DOUBLE STRANDED RNA COMPOUNDS TO RHOA AND USE THEREOF.
HW675630 - JP 2014210789-A/46: Novel siRNA Structures.
HW835318 - JP 2015051004-A/46: Novel siRNA's and Use Thereof.
JA394581 - Sequence 3 from Patent WO2011066475.
JA482127 - Sequence 110 from Patent WO2011072091.
JA538161 - Sequence 46 from Patent EP2371958.
JA722527 - Sequence 1 from Patent WO2011163436.
JB251978 - Sequence 45 from Patent EP2440214.
JB614855 - Sequence 6 from Patent WO2013070821.
JE980419 - Sequence 110 from Patent EP2862929.
LF384593 - JP 2014500723-A/192096: Polycomb-Associated Non-Coding RNAs.
LP764877 - Sequence 45 from Patent EP3276004.
AK130066 - Homo sapiens cDNA FLJ26556 fis, clone LNF01953, highly similar to Transforming protein RhoA.
AK130808 - Homo sapiens cDNA FLJ27298 fis, clone TMS04601, highly similar to Transforming protein RhoA.
BC001360 - Homo sapiens ras homolog gene family, member A, mRNA (cDNA clone MGC:2330 IMAGE:3051460), complete cds.
GQ900995 - Homo sapiens clone HEL-T-107 epididymis secretory sperm binding protein mRNA, complete cds.
BC005976 - Homo sapiens ras homolog gene family, member A, mRNA (cDNA clone MGC:14663 IMAGE:4102976), complete cds.
X05026 - Human rho mRNA (clone 12).
AK307220 - Homo sapiens cDNA, FLJ97168.
AK296654 - Homo sapiens cDNA FLJ57740 complete cds, highly similar to Transforming protein RhoA precursor.
MA620170 - JP 2018138019-A/192096: Polycomb-Associated Non-Coding RNAs.
BC000946 - Homo sapiens ras homolog gene family, member A, mRNA (cDNA clone IMAGE:3449658), partial cds.
L09159 - Homo sapiens RHOA proto-oncogene multi-drug-resistance protein mRNA, 3' end.
LF378548 - JP 2014500723-A/186051: Polycomb-Associated Non-Coding RNAs.
JD385425 - Sequence 366449 from Patent EP1572962.
JD280997 - Sequence 262021 from Patent EP1572962.
JD198846 - Sequence 179870 from Patent EP1572962.
JD119754 - Sequence 100778 from Patent EP1572962.
LF378547 - JP 2014500723-A/186050: Polycomb-Associated Non-Coding RNAs.
JD410000 - Sequence 391024 from Patent EP1572962.
LF207169 - JP 2014500723-A/14672: Polycomb-Associated Non-Coding RNAs.
LF378546 - JP 2014500723-A/186049: Polycomb-Associated Non-Coding RNAs.
JD349799 - Sequence 330823 from Patent EP1572962.
LF378545 - JP 2014500723-A/186048: Polycomb-Associated Non-Coding RNAs.
JD427170 - Sequence 408194 from Patent EP1572962.
JD161077 - Sequence 142101 from Patent EP1572962.
LF378544 - JP 2014500723-A/186047: Polycomb-Associated Non-Coding RNAs.
JD185486 - Sequence 166510 from Patent EP1572962.
JD040052 - Sequence 21076 from Patent EP1572962.
LF378543 - JP 2014500723-A/186046: Polycomb-Associated Non-Coding RNAs.
LN607834 - Homo sapiens partial mRNA for Ras homolog family member A (RHOA gene).
AF498970 - Homo sapiens small GTP binding protein RhoA (ARHA) mRNA, complete cds.
CU675211 - Synthetic construct Homo sapiens gateway clone IMAGE:100020236 5' read RHOA mRNA.
KJ890706 - Synthetic construct Homo sapiens clone ccsbBroadEn_00100 RHOA gene, encodes complete protein.
KJ896452 - Synthetic construct Homo sapiens clone ccsbBroadEn_05846 RHOA gene, encodes complete protein.
EU831594 - Synthetic construct Homo sapiens clone HAIB:100066623; DKFZo007B0119 ras homolog gene family, member A protein (RHOA) gene, encodes complete protein.
BT019870 - Homo sapiens ras homolog gene family, member A mRNA, complete cds.
EU831679 - Synthetic construct Homo sapiens clone HAIB:100066708; DKFZo003B0120 ras homolog gene family, member A protein (RHOA) gene, encodes complete protein.
AB385101 - Synthetic construct DNA, clone: pF1KB5448, Homo sapiens RHOA gene for transforming protein RhoA precursor, complete cds, without stop codon, in Flexi system.
LF378542 - JP 2014500723-A/186045: Polycomb-Associated Non-Coding RNAs.
LF378541 - JP 2014500723-A/186044: Polycomb-Associated Non-Coding RNAs.
LF378539 - JP 2014500723-A/186042: Polycomb-Associated Non-Coding RNAs.
LF378538 - JP 2014500723-A/186041: Polycomb-Associated Non-Coding RNAs.
MA614125 - JP 2018138019-A/186051: Polycomb-Associated Non-Coding RNAs.
MA614124 - JP 2018138019-A/186050: Polycomb-Associated Non-Coding RNAs.
MA442746 - JP 2018138019-A/14672: Polycomb-Associated Non-Coding RNAs.
MA614123 - JP 2018138019-A/186049: Polycomb-Associated Non-Coding RNAs.
MA614122 - JP 2018138019-A/186048: Polycomb-Associated Non-Coding RNAs.
MA614121 - JP 2018138019-A/186047: Polycomb-Associated Non-Coding RNAs.
MA614120 - JP 2018138019-A/186046: Polycomb-Associated Non-Coding RNAs.
MA614119 - JP 2018138019-A/186045: Polycomb-Associated Non-Coding RNAs.
MA614118 - JP 2018138019-A/186044: Polycomb-Associated Non-Coding RNAs.
MA614116 - JP 2018138019-A/186042: Polycomb-Associated Non-Coding RNAs.
MA614115 - JP 2018138019-A/186041: Polycomb-Associated Non-Coding RNAs.
JD024565 - Sequence 5589 from Patent EP1572962.
JD036300 - Sequence 17324 from Patent EP1572962.
JD033462 - Sequence 14486 from Patent EP1572962.
LF378534 - JP 2014500723-A/186037: Polycomb-Associated Non-Coding RNAs.
MA614111 - JP 2018138019-A/186037: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_cardiacegfPathway - Role of EGF Receptor Transactivation by GPCRs in Cardiac Hypertrophy
h_malPathway - Role of MAL in Rho-Mediated Activation of SRF
h_akap13Pathway - Rho-Selective Guanine Exchange Factor AKAP13 Mediates Stress Fiber Formation
h_ecmPathway - Erk and PI-3 Kinase Are Necessary for Collagen Binding in Corneal Epithelia
h_rhoPathway - Rho cell motility signaling pathway
h_Par1Pathway - Thrombin signaling and protease-activated receptors
h_RacCycDPathway - Influence of Ras and Rho proteins on G1 to S Transition
h_edg1Pathway - Phospholipids as signalling intermediaries
h_integrinPathway - Integrin Signaling Pathway
h_cdc42racPathway - Role of PI3K subunit p85 in regulation of Actin Organization and Cell Migration
h_tffPathway - Trefoil Factors Initiate Mucosal Healing
h_CCR3Pathway - CCR3 signaling in Eosinophils
h_rasPathway - Ras Signaling Pathway
h_ucalpainPathway - uCalpain and friends in Cell spread
h_akapCentrosomePathway - Protein Kinase A at the Centrosome

Reactome (by CSHL, EBI, and GO)

Protein P61586 (Reactome details) participates in the following event(s):

R-HSA-202692 PIP3 binds to RhoA and activates it
R-NUL-350485 RhoA:GTP binds to activated Daam1
R-HSA-416559 Inactivation of Rho-GTP by p190RhoGAP
R-HSA-3928576 RHOA:GTP binds ROCK, activating it
R-HSA-3928647 RHOA:GTP:Mg2+ binds ROCK1,ROCK2
R-HSA-5665989 DIAPH1 binds RHOA:GTP
R-HSA-5667008 RHOA:GTP binds RHPN1 or RHPN2
R-HSA-8849085 ARHGAP35 binds RHOA:GTP
R-HSA-8985594 MYO9B inactivates RHOA
R-HSA-194518 RhoA is activated by nucleotide exchange and inhibits axonal growth
R-HSA-3928592 p190RhoGEF exchanges GTP for GDP on RHOA, activating it
R-HSA-3928651 NGEF exchanges GTP for GDP on RHOA
R-HSA-193696 The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA
R-HSA-8849082 ARHGAP35 stimulates RHOA GTPase activity
R-HSA-6800426 Exocytosis of ficolin-rich granule membrane proteins
R-HSA-6798743 Exocytosis of secretory granule membrane proteins
R-HSA-3858495 DAAM1 recruits GTP-bound RHOA
R-HSA-5690843 OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA
R-NUL-2161147 TGFBR1 is recruited to tight junction by binding Pard6a
R-HSA-2134506 TGFBR1 is recruited to tight junctions by PARD6A
R-HSA-5228992 ROCK1,ROCK2 are activated
R-HSA-5665982 RHOA:GTP:DIAPH1 binds EVL and sequesters profilin:G-actin from MKL1
R-HSA-6785648 MEMO1 binds RHOA:GTP:DIAPH1
R-HSA-5666197 RHOA:GTP:RTKN binds LIN7B
R-HSA-5666216 RHOA:GTP:RTKN binds TAX1BP3
R-HSA-5667052 ROPN1 binds RHOA:GTP:RHPN1
R-HSA-5625901 CIT (citron kinase) binds activated RHOA, RHOB, RHOC and RAC1
R-HSA-8981443 CIT-3 binds activated RHOA, RHOB, RHOC and RAC1
R-HSA-193668 p75NTR and RHOA-GDI interact
R-HSA-9012761 The p75NTR:NgR:MDGI binds RHOA-GDI
R-HSA-194894 Rho GTPase:GTP activates downstream effectors
R-HSA-194922 GAPs inactivate Rho GTPase:GTP by hydrolysis
R-HSA-194913 GEFs activate Rho GTPase:GDP
R-HSA-194854 GDIs block activation of Rho GTPase:GDP
R-HSA-419049 ROCK activation by RHO
R-HSA-5666178 RTKN binds RHOA, RHOC or RHOB
R-HSA-416588 Activation of Rho by LARG and PDZ-RhoGEF
R-HSA-419166 GEFs activate RhoA,B,C
R-HSA-5623622 RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3
R-HSA-5623667 PDPK1 phosphorylates PKN1,2,3
R-HSA-195146 Dissociation of Rho GTP:GDP from GDI complex
R-HSA-442291 VAV2 is a GEF for Rho/Rac family kinases
R-HSA-442314 VAV3 is a GEF for Rho/Rac family kinases
R-HSA-114542 Rac1 activation of PI3K
R-HSA-114544 p115-RhoGEF activation of Rac1
R-HSA-442273 VAV1 is a GEF for Rho/Rac family kinases
R-HSA-2160932 SMURF1 binds phosphorylated PARD6A
R-HSA-2134532 TGFBR2 phosphorylates TGFBR1 and PARD6A
R-NUL-2161165 TGFBR2 phosphorylates Pard6a
R-NUL-2161160 TGFBR2 is recruited to tight junctions-associated, Pard6a-bound, TGFBR1 after TGF-beta stimulation
R-HSA-5625959 Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin)
R-HSA-2134519 TGFBR2 is recruited to tight junctions after TGF-beta stimulation
R-HSA-3928577 ROCK phosphorylates LIMK1,2
R-HSA-3928616 Activated ROCK phosphorylates MRLCs
R-HSA-5671970 Activated CIT binds KIF14 and PRC1
R-HSA-5671993 CIT-3 binds DLG4
R-HSA-193646 NGF binding to p75NTR inactivates RHOA
R-HSA-5623632 RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3
R-HSA-5218826 Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732
R-HSA-2160935 SMURF1 ubiquitinates RHOA
R-HSA-5672083 KTN1 binds Kinesin-1
R-HSA-5671919 Activated CIT phosphorylates MRLCs
R-HSA-419083 Myosin phosphatase inactivation by ROCK
R-HSA-419087 LIM kinase phosphorylation by ROCK
R-HSA-419197 Myosin regulatory light chain phosphorylation by ROCK
R-HSA-198203 PI3K/AKT activation
R-HSA-392451 G beta:gamma signalling through PI3Kgamma
R-HSA-416550 Sema4D mediated inhibition of cell attachment and migration
R-HSA-3928662 EPHB-mediated forward signaling
R-HSA-4420097 VEGFA-VEGFR2 Pathway
R-HSA-5663220 RHO GTPases Activate Formins
R-HSA-5666185 RHO GTPases Activate Rhotekin and Rhophilins
R-HSA-8849471 PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
R-HSA-8985586 SLIT2:ROBO1 increases RHOA activity
R-HSA-193634 Axonal growth inhibition (RHOA activation)
R-HSA-3928663 EPHA-mediated growth cone collapse
R-HSA-6798695 Neutrophil degranulation
R-HSA-187037 Signaling by NTRK1 (TRKA)
R-HSA-397795 G-protein beta:gamma signalling
R-HSA-4086400 PCP/CE pathway
R-HSA-5689896 Ovarian tumor domain proteases
R-HSA-2173791 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
R-HSA-6785631 ERBB2 Regulates Cell Motility
R-HSA-5625900 RHO GTPases activate CIT
R-HSA-400685 Sema4D in semaphorin signaling
R-HSA-2682334 EPH-Ephrin signaling
R-HSA-194138 Signaling by VEGF
R-HSA-195258 RHO GTPase Effectors
R-HSA-8848021 Signaling by PTK6
R-HSA-376176 Signaling by ROBO receptors
R-HSA-193697 p75NTR regulates axonogenesis
R-HSA-209563 Axonal growth stimulation
R-HSA-194840 Rho GTPase cycle
R-HSA-416482 G alpha (12/13) signalling events
R-HSA-416572 Sema4D induced cell migration and growth-cone collapse
R-HSA-5627117 RHO GTPases Activate ROCKs
R-HSA-5625740 RHO GTPases activate PKNs
R-HSA-168249 Innate Immune System
R-HSA-166520 Signaling by NTRKs
R-HSA-388396 GPCR downstream signalling
R-HSA-3858494 Beta-catenin independent WNT signaling
R-HSA-114604 GPVI-mediated activation cascade
R-HSA-5688426 Deubiquitination
R-HSA-5625970 RHO GTPases activate KTN1
R-HSA-170834 Signaling by TGF-beta Receptor Complex
R-HSA-1227986 Signaling by ERBB2
R-HSA-373755 Semaphorin interactions
R-HSA-422475 Axon guidance
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-194315 Signaling by Rho GTPases
R-HSA-9006927 Signaling by Non-Receptor Tyrosine Kinases
R-HSA-193704 p75 NTR receptor-mediated signalling
R-HSA-168256 Immune System
R-HSA-372790 Signaling by GPCR
R-HSA-195721 Signaling by WNT
R-HSA-76002 Platelet activation, signaling and aggregation
R-HSA-597592 Post-translational protein modification
R-HSA-9006936 Signaling by TGF-beta family members
R-HSA-1266738 Developmental Biology
R-HSA-162582 Signal Transduction
R-HSA-73887 Death Receptor Signalling
R-HSA-109582 Hemostasis
R-HSA-392499 Metabolism of proteins

-  Other Names for This Gene
  Alternate Gene Symbols: ARH12, ARHA, ENST00000418115.1, ENST00000418115.2, ENST00000418115.3, ENST00000418115.4, ENST00000418115.5, NM_001664, P06749, P61586, Q53HM4, Q5U024, Q9UDJ0, Q9UEJ4, RHO12, RHOA , RHOA_HUMAN, uc319nsy.1, uc319nsy.2
UCSC ID: ENST00000418115.6_7
RefSeq Accession: NM_001664.4
Protein: P61586 (aka RHOA_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.