Human Gene RHOC (ENST00000339083.12_8) from GENCODE V47lift37
Description: ras homolog family member C, transcript variant 1 (from RefSeq NM_175744.5)
Gencode Transcript: ENST00000339083.12_8
Gencode Gene: ENSG00000155366.17_12
Transcript (Including UTRs)
Position: hg19 chr1:113,243,753-113,249,749 Size: 5,997 Total Exon Count: 6 Strand: -
Coding Region
Position: hg19 chr1:113,244,162-113,246,421 Size: 2,260 Coding Exon Count: 4
Data last updated at UCSC: 2024-08-22 23:36:26
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: RHOC_HUMAN
DESCRIPTION: RecName: Full=Rho-related GTP-binding protein RhoC; AltName: Full=Rho cDNA clone 9; Short=h9; Flags: Precursor;
FUNCTION: Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial epithelial cells.SUBUNIT: Interacts with RTKN (By similarity). Interacts with AKAP13, DIAPH1, PKN2, ROCK1 and ROCK2.SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential). Cleavage furrow. Note=Translocates to the equatorial region before furrow formation in a ECT2-dependent manner.SIMILARITY: Belongs to the small GTPase superfamily. Rho family.WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/RHOCID42110ch1p13.html";
Primer design for this transcript
MalaCards Disease Associations
Comparative Toxicogenomics Database (CTD)
Common Gene Haplotype Alleles
Press "+" in the title bar above to open this section.
RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
Press "+" in the title bar above to open this section.
mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR005225 - Small_GTP-bd_dom
IPR001806 - Small_GTPase
IPR003578 - Small_GTPase_Rho
Pfam Domains: PF00025 - ADP-ribosylation factor family
PF00071 - Ras family
PF08477 - Ras of Complex, Roc, domain of DAPkinase
SCOP Domains: 51735 - NAD(P)-binding Rossmann-fold domains
52540 - P-loop containing nucleoside triphosphate hydrolases
Protein Data Bank (PDB) 3-D Structure
ModBase Predicted Comparative 3D Structure on P08134
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
LF206278 - JP 2014500723-A/13781: Polycomb-Associated Non-Coding RNAs.LF213713 - JP 2014500723-A/21216: Polycomb-Associated Non-Coding RNAs.BC052808 - Homo sapiens ras homolog gene family, member C, mRNA (cDNA clone MGC:61427 IMAGE:6064555), complete cds.BC007245 - Homo sapiens ras homolog gene family, member C, mRNA (cDNA clone MGC:15462 IMAGE:2966676), complete cds.BC009177 - Homo sapiens ras homolog gene family, member C, mRNA (cDNA clone MGC:1448 IMAGE:2988783), complete cds.GQ900972 - Homo sapiens clone HEL-T-84 epididymis secretory sperm binding protein mRNA, complete cds.BX648784 - Homo sapiens mRNA; cDNA DKFZp686F07165 (from clone DKFZp686F07165).AK094474 - Homo sapiens cDNA FLJ37155 fis, clone BRACE2026131, highly similar to Rho-related GTP-binding protein RhoC precursor.L25081 - Homo sapiens GTPase (rhoC) mRNA, complete cds.AF498972 - Homo sapiens small GTP binding protein RhoC (ARHC) mRNA, complete cds.X06821 - Human rhoC mRNA (clone 9).CU675583 - Synthetic construct Homo sapiens gateway clone IMAGE:100020767 5' read RHOC mRNA.KJ890707 - Synthetic construct Homo sapiens clone ccsbBroadEn_00101 RHOC gene, encodes complete protein.BT019448 - Homo sapiens hypothetical protein MGC19531 mRNA, complete cds.DQ893171 - Synthetic construct clone IMAGE:100005801; FLH194607.01X; RZPDo839D0280D ras homolog gene family, member C (RHOC) gene, encodes complete protein.DQ896470 - Synthetic construct Homo sapiens clone IMAGE:100010930; FLH194603.01L; RZPDo839D0270D ras homolog gene family, member C (RHOC) gene, encodes complete protein.CR450360 - Homo sapiens full open reading frame cDNA clone RZPDo834C073D for gene ARHC, ras homolog gene family, member C; complete cds; without stopcodon.AB528518 - Synthetic construct DNA, clone: pF1KB3630, Homo sapiens RHOC gene for ras homolog gene family, member C, without stop codon, in Flexi system.MA441855 - JP 2018138019-A/13781: Polycomb-Associated Non-Coding RNAs.MA449290 - JP 2018138019-A/21216: Polycomb-Associated Non-Coding RNAs.JD387103 - Sequence 368127 from Patent EP1572962.JD320831 - Sequence 301855 from Patent EP1572962.JD203019 - Sequence 184043 from Patent EP1572962.JD383036 - Sequence 364060 from Patent EP1572962.LF352906 - JP 2014500723-A/160409: Polycomb-Associated Non-Coding RNAs.JD293603 - Sequence 274627 from Patent EP1572962.JD223392 - Sequence 204416 from Patent EP1572962.LF352905 - JP 2014500723-A/160408: Polycomb-Associated Non-Coding RNAs.JD041539 - Sequence 22563 from Patent EP1572962.JD085995 - Sequence 67019 from Patent EP1572962.JD130284 - Sequence 111308 from Patent EP1572962.AF085893 - Homo sapiens full length insert cDNA clone YP95A10.LF352904 - JP 2014500723-A/160407: Polycomb-Associated Non-Coding RNAs.LF352903 - JP 2014500723-A/160406: Polycomb-Associated Non-Coding RNAs.MA588483 - JP 2018138019-A/160409: Polycomb-Associated Non-Coding RNAs.MA588482 - JP 2018138019-A/160408: Polycomb-Associated Non-Coding RNAs.MA588481 - JP 2018138019-A/160407: Polycomb-Associated Non-Coding RNAs.MA588480 - JP 2018138019-A/160406: Polycomb-Associated Non-Coding RNAs.DQ571176 - Homo sapiens piRNA piR-31288, complete sequence.DQ577103 - Homo sapiens piRNA piR-45215, complete sequence.JD027197 - Sequence 8221 from Patent EP1572962.JD029880 - Sequence 10904 from Patent EP1572962.JD035896 - Sequence 16920 from Patent EP1572962.JD191891 - Sequence 172915 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO) Protein P08134 (Reactome details) participates in the following event(s):R-HSA-5665748 FMNL2 binds RHOC:GTP
R-HSA-5665761 FMNL3 binds RHOC:GTP
R-HSA-195146 Dissociation of Rho GTP:GDP from GDI complex
R-HSA-5665767 Activated FMNL3 binds G-actin
R-HSA-5625901 CIT (citron kinase) binds activated RHOA, RHOB, RHOC and RAC1
R-HSA-8981443 CIT-3 binds activated RHOA, RHOB, RHOC and RAC1
R-HSA-194894 Rho GTPase:GTP activates downstream effectors
R-HSA-194922 GAPs inactivate Rho GTPase:GTP by hydrolysis
R-HSA-194913 GEFs activate Rho GTPase:GDP
R-HSA-194854 GDIs block activation of Rho GTPase:GDP
R-HSA-419049 ROCK activation by RHO
R-HSA-5666178 RTKN binds RHOA, RHOC or RHOB
R-HSA-416588 Activation of Rho by LARG and PDZ-RhoGEF
R-HSA-419166 GEFs activate RhoA,B,C
R-HSA-5623622 RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3
R-HSA-5623667 PDPK1 phosphorylates PKN1,2,3
R-HSA-5671970 Activated CIT binds KIF14 and PRC1
R-HSA-5671993 CIT-3 binds DLG4
R-HSA-5623632 RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3
R-HSA-5671919 Activated CIT phosphorylates MRLCs
R-HSA-419083 Myosin phosphatase inactivation by ROCK
R-HSA-419087 LIM kinase phosphorylation by ROCK
R-HSA-419197 Myosin regulatory light chain phosphorylation by ROCK
R-HSA-5663220 RHO GTPases Activate Formins
R-HSA-194840 Rho GTPase cycle
R-HSA-5625900 RHO GTPases activate CIT
R-HSA-195258 RHO GTPase Effectors
R-HSA-416482 G alpha (12/13) signalling events
R-HSA-416572 Sema4D induced cell migration and growth-cone collapse
R-HSA-5627117 RHO GTPases Activate ROCKs
R-HSA-5666185 RHO GTPases Activate Rhotekin and Rhophilins
R-HSA-5625740 RHO GTPases activate PKNs
R-HSA-194315 Signaling by Rho GTPases
R-HSA-388396 GPCR downstream signalling
R-HSA-400685 Sema4D in semaphorin signaling
R-HSA-162582 Signal Transduction
R-HSA-372790 Signaling by GPCR
R-HSA-373755 Semaphorin interactions
R-HSA-422475 Axon guidance
R-HSA-1266738 Developmental Biology
Other Names for This Gene
Alternate Gene Symbols: ARH9, ARHC, B3KSW1, ENST00000339083.1, ENST00000339083.10, ENST00000339083.11, ENST00000339083.2, ENST00000339083.3, ENST00000339083.4, ENST00000339083.5, ENST00000339083.6, ENST00000339083.7, ENST00000339083.8, ENST00000339083.9, NM_175744, P08134, Q6ICN3, RHOC_HUMAN, uc317vft.1, uc317vft.2UCSC ID: ENST00000339083.12_8RefSeq Accession: NM_175744.5
Protein: P08134
(aka RHOC_HUMAN)
Gene Model Information
Click here
for a detailed description of the fields of the table above.
Methods, Credits, and Use Restrictions
Click here
for details on how this gene model was made and data restrictions if any.