Human Gene RICTOR (ENST00000357387.8_14) from GENCODE V47lift37
  Description: RPTOR independent companion of MTOR complex 2, transcript variant 1 (from RefSeq NM_152756.5)
Gencode Transcript: ENST00000357387.8_14
Gencode Gene: ENSG00000164327.14_17
Transcript (Including UTRs)
   Position: hg19 chr5:38,938,022-39,074,501 Size: 136,480 Total Exon Count: 38 Strand: -
Coding Region
   Position: hg19 chr5:38,942,406-39,074,479 Size: 132,074 Coding Exon Count: 38 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr5:38,938,022-39,074,501)mRNA (may differ from genome)Protein (1708 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedReactome
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: RICTR_HUMAN
DESCRIPTION: RecName: Full=Rapamycin-insensitive companion of mTOR; AltName: Full=AVO3 homolog; Short=hAVO3;
FUNCTION: Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient- insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Plays an essential role in embryonic growth and development.
SUBUNIT: Part of the mammalian target of rapamycin complex 2 (mTORC2) which contains MTOR, MLST8, PRR5, RICTOR, MAPKAP1 and DEPTOR. Contrary to mTORC1, mTORC2 does not bind to and is not sensitive to FKBP12-rapamycin. Binds directly to MTOR and PRR5 within the TORC2 complex. May interact with PRR5L.
INTERACTION: Q13418:ILK; NbExp=8; IntAct=EBI-1387196, EBI-747644; P42345:MTOR; NbExp=17; IntAct=EBI-1387196, EBI-359260; Q8TCU6:PREX1; NbExp=3; IntAct=EBI-1387196, EBI-1046542;
PTM: Phosphorylated by MTOR; when part of mTORC2. Phosphorylated at Thr-1135 by RPS6KB1; phosphorylation of RICTOR inhibits mTORC2 and AKT1 signaling.
SIMILARITY: Belongs to the pianissimo family.
SEQUENCE CAUTION: Sequence=CAH18135.1; Type=Miscellaneous discrepancy; Note=Wrong choice of CDS;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: RICTOR
Diseases sorted by gene-association score: bardet-biedl syndrome (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene
  • D001564 Benzo(a)pyrene
  • C532162 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine
  • D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
  • D000082 Acetaminophen
  • D016604 Aflatoxin B1
  • D003010 Clorgyline
  • D003375 Coumestrol
  • D005557 Formaldehyde
  • D018817 N-Methyl-3,4-methylenedioxyamphetamine
  • D010634 Phenobarbital
          more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 8.62 RPKM in Uterus
Total median expression: 266.79 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -2.9022-0.132 Picture PostScript Text
3' UTR -1016.804384-0.232 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011989 - ARM-like
IPR016024 - ARM-type_fold

Pfam Domains:
PF14663 - Rapamycin-insensitive companion of mTOR RasGEF_N domain
PF14664 - Rapamycin-insensitive companion of mTOR, N-term
PF14665 - Rapamycin-insensitive companion of mTOR, phosphorylation-site
PF14666 - Rapamycin-insensitive companion of mTOR, middle domain
PF14668 - Rapamycin-insensitive companion of mTOR, domain 5

SCOP Domains:
48371 - ARM repeat
47954 - Cyclin-like

ModBase Predicted Comparative 3D Structure on Q6R327
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologGenome Browser
Gene DetailsGene Details Gene DetailsGene DetailsGene Details
Gene SorterGene Sorter Gene SorterGene SorterGene Sorter
 RGD  WormBaseSGD
     Protein Sequence
     Alignment

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0008047 enzyme activator activity
GO:0019901 protein kinase binding
GO:0043022 ribosome binding

Biological Process:
GO:0001932 regulation of protein phosphorylation
GO:0001938 positive regulation of endothelial cell proliferation
GO:0007275 multicellular organism development
GO:0009792 embryo development ending in birth or egg hatching
GO:0010468 regulation of gene expression
GO:0018105 peptidyl-serine phosphorylation
GO:0030010 establishment of cell polarity
GO:0030838 positive regulation of actin filament polymerization
GO:0030950 establishment or maintenance of actin cytoskeleton polarity
GO:0031532 actin cytoskeleton reorganization
GO:0031929 TOR signaling
GO:0032008 positive regulation of TOR signaling
GO:0032148 activation of protein kinase B activity
GO:0032956 regulation of actin cytoskeleton organization
GO:0033135 regulation of peptidyl-serine phosphorylation
GO:0042325 regulation of phosphorylation
GO:0043087 regulation of GTPase activity
GO:0050727 regulation of inflammatory response
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0051896 regulation of protein kinase B signaling
GO:0051897 positive regulation of protein kinase B signaling
GO:2000114 regulation of establishment of cell polarity

Cellular Component:
GO:0005829 cytosol
GO:0031932 TORC2 complex


-  Descriptions from all associated GenBank mRNAs
  LF210221 - JP 2014500723-A/17724: Polycomb-Associated Non-Coding RNAs.
CR749280 - Homo sapiens mRNA; cDNA DKFZp686B11164 (from clone DKFZp686B11164).
BC137163 - Homo sapiens rapamycin-insensitive companion of mTOR, mRNA (cDNA clone MGC:168783 IMAGE:9021160), complete cds.
BC144509 - Homo sapiens rapamycin-insensitive companion of mTOR, mRNA (cDNA clone MGC:178053 IMAGE:9053036), complete cds.
BC137164 - Homo sapiens rapamycin-insensitive companion of mTOR, mRNA (cDNA clone MGC:168784 IMAGE:9021161), complete cds.
AY515854 - Homo sapiens rapamycin insensitive companion of mTOR mRNA, complete cds.
AK128358 - Homo sapiens cDNA FLJ46501 fis, clone THYMU3029774.
BC029608 - Homo sapiens rapamycin-insensitive companion of mTOR, mRNA (cDNA clone IMAGE:5302244), complete cds.
CU688716 - Synthetic construct Homo sapiens gateway clone IMAGE:100016929 5' read RICTOR mRNA.
DQ891672 - Synthetic construct clone IMAGE:100004302; FLH179161.01X; RZPDo839D06130D rapamycin-insensitive companion of mTOR (RICTOR) gene, encodes complete protein.
KJ904055 - Synthetic construct Homo sapiens clone ccsbBroadEn_13449 RICTOR gene, encodes complete protein.
DQ894858 - Synthetic construct Homo sapiens clone IMAGE:100009318; FLH179157.01L; RZPDo839D06129D rapamycin-insensitive companion of mTOR (RICTOR) gene, encodes complete protein.
MA445798 - JP 2018138019-A/17724: Polycomb-Associated Non-Coding RNAs.
AB082530 - Homo sapiens mRNA for KIAA1999 protein.
AK024327 - Homo sapiens cDNA FLJ14265 fis, clone PLACE1002256.
AK127305 - Homo sapiens cDNA FLJ45373 fis, clone BRHIP3018784.
AK094538 - Homo sapiens cDNA FLJ37219 fis, clone BRALZ2009446.
JD315399 - Sequence 296423 from Patent EP1572962.
JD504089 - Sequence 485113 from Patent EP1572962.
JD036583 - Sequence 17607 from Patent EP1572962.
JD251125 - Sequence 232149 from Patent EP1572962.
JD238628 - Sequence 219652 from Patent EP1572962.
JD083473 - Sequence 64497 from Patent EP1572962.
JD299917 - Sequence 280941 from Patent EP1572962.
JD509162 - Sequence 490186 from Patent EP1572962.
JD094483 - Sequence 75507 from Patent EP1572962.
JD094517 - Sequence 75541 from Patent EP1572962.
JD091285 - Sequence 72309 from Patent EP1572962.
JD284156 - Sequence 265180 from Patent EP1572962.
JD095484 - Sequence 76508 from Patent EP1572962.
JD341721 - Sequence 322745 from Patent EP1572962.
JD345401 - Sequence 326425 from Patent EP1572962.
LF335820 - JP 2014500723-A/143323: Polycomb-Associated Non-Coding RNAs.
JD349524 - Sequence 330548 from Patent EP1572962.
JD315484 - Sequence 296508 from Patent EP1572962.
BC051729 - Homo sapiens rapamycin-insensitive companion of mTOR, mRNA (cDNA clone IMAGE:5787163), partial cds.
AL834497 - Homo sapiens mRNA; cDNA DKFZp761C062 (from clone DKFZp761C062).
JD239850 - Sequence 220874 from Patent EP1572962.
JD127026 - Sequence 108050 from Patent EP1572962.
JD051028 - Sequence 32052 from Patent EP1572962.
JD507148 - Sequence 488172 from Patent EP1572962.
LF335819 - JP 2014500723-A/143322: Polycomb-Associated Non-Coding RNAs.
JD040281 - Sequence 21305 from Patent EP1572962.
JD154812 - Sequence 135836 from Patent EP1572962.
JD303826 - Sequence 284850 from Patent EP1572962.
JD244138 - Sequence 225162 from Patent EP1572962.
JD226042 - Sequence 207066 from Patent EP1572962.
JD534196 - Sequence 515220 from Patent EP1572962.
JD551425 - Sequence 532449 from Patent EP1572962.
LF335818 - JP 2014500723-A/143321: Polycomb-Associated Non-Coding RNAs.
JD288945 - Sequence 269969 from Patent EP1572962.
JD363387 - Sequence 344411 from Patent EP1572962.
JD087505 - Sequence 68529 from Patent EP1572962.
JD262581 - Sequence 243605 from Patent EP1572962.
JD553721 - Sequence 534745 from Patent EP1572962.
JD450099 - Sequence 431123 from Patent EP1572962.
JD288221 - Sequence 269245 from Patent EP1572962.
JD331395 - Sequence 312419 from Patent EP1572962.
LF335817 - JP 2014500723-A/143320: Polycomb-Associated Non-Coding RNAs.
JD299266 - Sequence 280290 from Patent EP1572962.
JD423867 - Sequence 404891 from Patent EP1572962.
JD545431 - Sequence 526455 from Patent EP1572962.
JD420565 - Sequence 401589 from Patent EP1572962.
LF335815 - JP 2014500723-A/143318: Polycomb-Associated Non-Coding RNAs.
LF335814 - JP 2014500723-A/143317: Polycomb-Associated Non-Coding RNAs.
LF335813 - JP 2014500723-A/143316: Polycomb-Associated Non-Coding RNAs.
LF335810 - JP 2014500723-A/143313: Polycomb-Associated Non-Coding RNAs.
LF335808 - JP 2014500723-A/143311: Polycomb-Associated Non-Coding RNAs.
LF335807 - JP 2014500723-A/143310: Polycomb-Associated Non-Coding RNAs.
LF335806 - JP 2014500723-A/143309: Polycomb-Associated Non-Coding RNAs.
JD357520 - Sequence 338544 from Patent EP1572962.
LF335799 - JP 2014500723-A/143302: Polycomb-Associated Non-Coding RNAs.
MA571397 - JP 2018138019-A/143323: Polycomb-Associated Non-Coding RNAs.
MA571396 - JP 2018138019-A/143322: Polycomb-Associated Non-Coding RNAs.
MA571395 - JP 2018138019-A/143321: Polycomb-Associated Non-Coding RNAs.
MA571394 - JP 2018138019-A/143320: Polycomb-Associated Non-Coding RNAs.
MA571392 - JP 2018138019-A/143318: Polycomb-Associated Non-Coding RNAs.
MA571391 - JP 2018138019-A/143317: Polycomb-Associated Non-Coding RNAs.
MA571390 - JP 2018138019-A/143316: Polycomb-Associated Non-Coding RNAs.
MA571387 - JP 2018138019-A/143313: Polycomb-Associated Non-Coding RNAs.
MA571385 - JP 2018138019-A/143311: Polycomb-Associated Non-Coding RNAs.
MA571384 - JP 2018138019-A/143310: Polycomb-Associated Non-Coding RNAs.
MA571383 - JP 2018138019-A/143309: Polycomb-Associated Non-Coding RNAs.
MA571376 - JP 2018138019-A/143302: Polycomb-Associated Non-Coding RNAs.
JD055362 - Sequence 36386 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q6R327 (Reactome details) participates in the following event(s):

R-HSA-198640 TORC2 (mTOR) phosphorylates AKT at S473
R-HSA-2243938 AKT1 E17K mutant is phosphorylated by TORC2 complex
R-HSA-6795290 TORC2 complex phosphorylates SGK1
R-HSA-389357 CD28 dependent PI3K/Akt signaling
R-HSA-1257604 PIP3 activates AKT signaling
R-HSA-5218920 VEGFR2 mediated vascular permeability
R-HSA-5674400 Constitutive Signaling by AKT1 E17K in Cancer
R-HSA-6804757 Regulation of TP53 Degradation
R-HSA-389356 CD28 co-stimulation
R-HSA-9006925 Intracellular signaling by second messengers
R-HSA-4420097 VEGFA-VEGFR2 Pathway
R-HSA-2219528 PI3K/AKT Signaling in Cancer
R-HSA-6806003 Regulation of TP53 Expression and Degradation
R-HSA-388841 Costimulation by the CD28 family
R-HSA-162582 Signal Transduction
R-HSA-194138 Signaling by VEGF
R-HSA-5663202 Diseases of signal transduction
R-HSA-5633007 Regulation of TP53 Activity
R-HSA-1280218 Adaptive Immune System
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-1643685 Disease
R-HSA-3700989 Transcriptional Regulation by TP53
R-HSA-168256 Immune System
R-HSA-212436 Generic Transcription Pathway
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)

-  Other Names for This Gene
  Alternate Gene Symbols: B2RNX0, B7ZMF7, ENST00000357387.1, ENST00000357387.2, ENST00000357387.3, ENST00000357387.4, ENST00000357387.5, ENST00000357387.6, ENST00000357387.7, KIAA1999 , NM_152756, Q68DT5, Q6R327, Q86UB7, Q8N3A0, Q8NCM6, RICTOR , RICTR_HUMAN, uc318aae.1, uc318aae.2
UCSC ID: ENST00000357387.8_14
RefSeq Accession: NM_152756.5
Protein: Q6R327 (aka RICTR_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.