ID:RICTR_HUMAN DESCRIPTION: RecName: Full=Rapamycin-insensitive companion of mTOR; AltName: Full=AVO3 homolog; Short=hAVO3; FUNCTION: Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient- insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Plays an essential role in embryonic growth and development. SUBUNIT: Part of the mammalian target of rapamycin complex 2 (mTORC2) which contains MTOR, MLST8, PRR5, RICTOR, MAPKAP1 and DEPTOR. Contrary to mTORC1, mTORC2 does not bind to and is not sensitive to FKBP12-rapamycin. Binds directly to MTOR and PRR5 within the TORC2 complex. May interact with PRR5L. INTERACTION: Q13418:ILK; NbExp=8; IntAct=EBI-1387196, EBI-747644; P42345:MTOR; NbExp=17; IntAct=EBI-1387196, EBI-359260; Q8TCU6:PREX1; NbExp=3; IntAct=EBI-1387196, EBI-1046542; PTM: Phosphorylated by MTOR; when part of mTORC2. Phosphorylated at Thr-1135 by RPS6KB1; phosphorylation of RICTOR inhibits mTORC2 and AKT1 signaling. SIMILARITY: Belongs to the pianissimo family. SEQUENCE CAUTION: Sequence=CAH18135.1; Type=Miscellaneous discrepancy; Note=Wrong choice of CDS;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF14663 - Rapamycin-insensitive companion of mTOR RasGEF_N domain PF14664 - Rapamycin-insensitive companion of mTOR, N-term PF14665 - Rapamycin-insensitive companion of mTOR, phosphorylation-site PF14666 - Rapamycin-insensitive companion of mTOR, middle domain PF14668 - Rapamycin-insensitive companion of mTOR, domain 5
SCOP Domains: 48371 - ARM repeat 47954 - Cyclin-like
ModBase Predicted Comparative 3D Structure on Q6R327
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0001932 regulation of protein phosphorylation GO:0001938 positive regulation of endothelial cell proliferation GO:0007275 multicellular organism development GO:0009792 embryo development ending in birth or egg hatching GO:0010468 regulation of gene expression GO:0018105 peptidyl-serine phosphorylation GO:0030010 establishment of cell polarity GO:0030838 positive regulation of actin filament polymerization GO:0030950 establishment or maintenance of actin cytoskeleton polarity GO:0031532 actin cytoskeleton reorganization GO:0031929 TOR signaling GO:0032008 positive regulation of TOR signaling GO:0032148 activation of protein kinase B activity GO:0032956 regulation of actin cytoskeleton organization GO:0033135 regulation of peptidyl-serine phosphorylation GO:0042325 regulation of phosphorylation GO:0043087 regulation of GTPase activity GO:0050727 regulation of inflammatory response GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation GO:0051896 regulation of protein kinase B signaling GO:0051897 positive regulation of protein kinase B signaling GO:2000114 regulation of establishment of cell polarity
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
