ID:RIPK4_HUMAN DESCRIPTION: RecName: Full=Receptor-interacting serine/threonine-protein kinase 4; EC=2.7.11.1; AltName: Full=Ankyrin repeat domain-containing protein 3; AltName: Full=PKC-delta-interacting protein kinase; FUNCTION: Involved in stratified epithelial development. It is a direct transcriptional target of TP63. Plays a role in NF-kappa-B activation. CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. SUBUNIT: Interacts with PRKCB (By similarity). Interacts with TRAF1, TRAF2, TRAF3 and TRAF5. Interacts with BIRC2/c-IAP1, BIRC3/c-IAP2 and XIAP/BIRC4. INTERACTION: Q13490:BIRC2; NbExp=3; IntAct=EBI-4422308, EBI-514538; Q13489:BIRC3; NbExp=3; IntAct=EBI-4422308, EBI-517709; P98170:XIAP; NbExp=2; IntAct=EBI-4422308, EBI-517127; SUBCELLULAR LOCATION: Cytoplasm. Membrane; Peripheral membrane protein (By similarity). PTM: May be phosphorylated by MAP3K2 and MAP3K3 (By similarity). PTM: Proteolytically cleaved by during Fas-induced apoptosis. Cleavage at Asp-388 and Asp-426. PTM: Polyubiquitinated with 'Lys-48' and 'Lys-63'-linked chains by BIRC2/c-IAP1 and BIRC3/c-IAP2, leading to activation of NF-kappa- B. DISEASE: Defects in RIPK4 are the cause of popliteal pterygium syndrome, lethal type (PPS-L) [MIM:263650]. An autosomal recessive disorder characterized by multiple popliteal pterygia leading to severe arthrogryposis, ankyloblepharon filiforme adnatum, filiform bands between the jaws, synostosis of the carpal/tarsal and phalangeal bones in the hands and feet, digital hypoplasia/aplasia, complete soft-tissue syndactyly, lack of nails, lack of scalp hair, eyebrows and eyelashes, blepharophimosis, cleft lip and/or palate, and hypoplastic external genitalia. Early lethality is common, although survival into childhood and beyond has been reported. SIMILARITY: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. SIMILARITY: Contains 10 ANK repeats. SIMILARITY: Contains 1 protein kinase domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P57078
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0002009 morphogenesis of an epithelium GO:0006468 protein phosphorylation GO:0016310 phosphorylation GO:0051092 positive regulation of NF-kappaB transcription factor activity
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
