ID:RIT1_HUMAN DESCRIPTION: RecName: Full=GTP-binding protein Rit1; AltName: Full=Ras-like protein expressed in many tissues; AltName: Full=Ras-like without CAAX protein 1; FUNCTION: Plays a crucial role in coupling NGF stimulation to the activation of both EPHB2 and MAPK14 signaling pathways and in NGF- dependent neuronal differentiation. ENZYME REGULATION: Alternate between an inactive form bound to GDP and an active form bound to GTP. SUBUNIT: Interacts with MLLT4, the C-terminal domain of RALGDS and RLF, but not with RIN1 and PIK3CA. RLF binds exclusively to the active GTP-bound form. Strongly interacts with BRAF, but only weakly with RAF1. BARF and RAF1 association is dependent upon the GTP-bound state. Interacts with RGL3 (By similarity). INTERACTION: Q13129:RLF; NbExp=3; IntAct=EBI-365845, EBI-958266; SUBCELLULAR LOCATION: Cell membrane. TISSUE SPECIFICITY: Expressed in many tissues. MISCELLANEOUS: Stimulation of the NGF and EGF receptor signaling pathways results in rapid and prolonged activation. MISCELLANEOUS: Shows rapid uncatalyzed guanine nucleotide dissociation rates, which are much faster than those of most Ras subfamily members. SIMILARITY: Belongs to the small GTPase superfamily. Ras family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q92963
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
LP895178 - Sequence 42 from Patent EP3253886. DQ579865 - Homo sapiens piRNA piR-47977, complete sequence. Y07566 - H.sapiens mRNA for RIT protein. BC104186 - Homo sapiens Ras-like without CAAX 1, mRNA (cDNA clone MGC:125864 IMAGE:40030939), complete cds. BC104187 - Homo sapiens Ras-like without CAAX 1, mRNA (cDNA clone MGC:125865 IMAGE:40030940), complete cds. U78165 - Human small G protein RIBB mRNA, complete cds. AK298768 - Homo sapiens cDNA FLJ52018 complete cds, highly similar to GTP-binding protein Rit1. U71203 - Human rit mRNA, complete cds. AF084462 - Homo sapiens GTP-binding protein ROC1 (ROC1) mRNA, complete cds. AF493923 - Homo sapiens Ras family small GTP binding protein RIT (RIT) mRNA, complete cds. AK314239 - Homo sapiens cDNA, FLJ94984, Homo sapiens Ras-like without CAAX 1 (RIT1), mRNA. KJ892007 - Synthetic construct Homo sapiens clone ccsbBroadEn_01401 RIT1 gene, encodes complete protein. CR407639 - Homo sapiens full open reading frame cDNA clone RZPDo834F082D for gene RIT1, Ras-like without CAAX 1 complete cds, without stopcodon. JD367417 - Sequence 348441 from Patent EP1572962. JD230935 - Sequence 211959 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q92963 (Reactome details) participates in the following event(s):
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
