ID:RIT2_HUMAN DESCRIPTION: RecName: Full=GTP-binding protein Rit2; AltName: Full=Ras-like protein expressed in neurons; AltName: Full=Ras-like without CAAX protein 2; FUNCTION: Binds and exchanges GTP and GDP (By similarity). SUBUNIT: Interacts with MLLT4, the C-terminal domain of RALGDS and RLF, but not with RIN1 and PIK3CA. RLF binds exclusively to the active GTP-bound form (By similarity). Binds calmodulin. Interacts with PLXNB3. SUBCELLULAR LOCATION: Nucleus. Cell membrane. Note=Colocalizes with PLXNB3 at the plasma membrane. TISSUE SPECIFICITY: Neuron-specific. MISCELLANEOUS: Shows rapid uncatalyzed guanine nucleotide dissociation rates, which are much faster than those of most Ras subfamily members (By similarity). SIMILARITY: Belongs to the small GTPase superfamily. Ras family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q99578
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0001932 regulation of protein phosphorylation GO:0007165 signal transduction GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway GO:0007264 small GTPase mediated signal transduction GO:0007265 Ras protein signal transduction GO:0007268 chemical synaptic transmission GO:0010976 positive regulation of neuron projection development GO:0010977 negative regulation of neuron projection development GO:0030100 regulation of endocytosis GO:0032489 regulation of Cdc42 protein signal transduction GO:0032507 maintenance of protein location in cell GO:0035556 intracellular signal transduction GO:0043410 positive regulation of MAPK cascade GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0050848 regulation of calcium-mediated signaling GO:0000165 MAPK cascade
U71204 - Human rin mRNA, complete cds. U78164 - Human Ras-like small GTPase RIBA mRNA, complete cds. U78166 - Human Ras-like small GTPase RIBA mRNA, alternatively spliced, complete cds. Y07565 - H.sapiens mRNA for RIN protein. BC018060 - Homo sapiens Ras-like without CAAX 2, mRNA (cDNA clone MGC:26503 IMAGE:4816017), complete cds. AF493922 - Homo sapiens Ras family small GTP binding protein RIN (RIN) mRNA, complete cds. AY563951 - Homo sapiens Ras family small GTP binding protein RIN mRNA, complete cds. AK313823 - Homo sapiens cDNA, FLJ94444, Homo sapiens Ras-like without CAAX 2 (RIT2), mRNA. KJ897471 - Synthetic construct Homo sapiens clone ccsbBroadEn_06865 RIT2 gene, encodes complete protein. JF432616 - Synthetic construct Homo sapiens clone IMAGE:100073853 Ras-like without CAAX 2 (RIT2) gene, encodes complete protein. AB590857 - Synthetic construct DNA, clone: pFN21AB6975, Homo sapiens RIT2 gene for Ras-like without CAAX 2, without stop codon, in Flexi system. JD301102 - Sequence 282126 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q99578 (Reactome details) participates in the following event(s):
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
