Human Gene RLN1 (ENST00000223862.2_7) from GENCODE V47lift37
  Description: relaxin 1 (from RefSeq NM_006911.4)
Gencode Transcript: ENST00000223862.2_7
Gencode Gene: ENSG00000107018.8_9
Transcript (Including UTRs)
   Position: hg19 chr9:5,334,930-5,339,876 Size: 4,947 Total Exon Count: 2 Strand: -
Coding Region
   Position: hg19 chr9:5,335,251-5,339,746 Size: 4,496 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr9:5,334,930-5,339,876)mRNA (may differ from genome)Protein (185 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MalacardsMGIOMIMPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: REL1_HUMAN
DESCRIPTION: RecName: Full=Prorelaxin H1; Contains: RecName: Full=Relaxin B chain; Contains: RecName: Full=Relaxin A chain; Flags: Precursor;
FUNCTION: Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix.
SUBUNIT: Heterodimer of a B chain and an A chain linked by two disulfide bonds.
SUBCELLULAR LOCATION: Secreted.
TISSUE SPECIFICITY: Prostate. Not expressed in placenta, decidua or ovary.
SIMILARITY: Belongs to the insulin family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: RLN1
Diseases sorted by gene-association score: preterm premature rupture of the membranes (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 1.27 RPKM in Prostate
Total median expression: 4.11 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -50.30130-0.387 Picture PostScript Text
3' UTR -45.80321-0.143 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR016179 - Insulin-like
IPR022353 - Insulin_CS
IPR022352 - Insulin_family
IPR022421 - Relaxin

Pfam Domains:
PF00049 - Insulin/IGF/Relaxin family

SCOP Domains:
158553 - TAFH domain-like
53474 - alpha/beta-Hydrolases
56994 - Insulin-like

ModBase Predicted Comparative 3D Structure on P04808
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005179 hormone activity

Biological Process:
GO:0007165 signal transduction
GO:0007565 female pregnancy
GO:0010469 regulation of receptor activity

Cellular Component:
GO:0005576 extracellular region


-  Descriptions from all associated GenBank mRNAs
  AF057705 - Homo sapiens relaxin H1 mRNA, 3' UTR.
BC005956 - Homo sapiens relaxin 1, mRNA (cDNA clone MGC:14599 IMAGE:4296811), complete cds.
JD303851 - Sequence 284875 from Patent EP1572962.
E00194 - DNA coding human preprorelaxin.
A06846 - H.sapiens mRNA for relaxin.
A06926 - H.sapiens mRNA for H1-relaxin.
A17317 - H.sapiens mRNA for H1-preprorelaxin.
A17329 - H.sapiens mRNA for preprorelaxin.
E00220 - cDNA encoding human H1-preprorelaxin.
X00949 - Human mRNA for prepro-relaxin H1.
KJ892005 - Synthetic construct Homo sapiens clone ccsbBroadEn_01399 RLN1 gene, encodes complete protein.
DQ893302 - Synthetic construct clone IMAGE:100005932; FLH194591.01X; RZPDo839C1280D relaxin 1 (RLN1) gene, encodes complete protein.
DQ896468 - Synthetic construct Homo sapiens clone IMAGE:100010928; FLH194587.01L; RZPDo839C1270D relaxin 1 (RLN1) gene, encodes complete protein.
E00193 - DNA coding human preprorelaxin.
JD103302 - Sequence 84326 from Patent EP1572962.
JD479601 - Sequence 460625 from Patent EP1572962.
JD045134 - Sequence 26158 from Patent EP1572962.
JD039056 - Sequence 20080 from Patent EP1572962.
JD155456 - Sequence 136480 from Patent EP1572962.
JD097289 - Sequence 78313 from Patent EP1572962.
JD408036 - Sequence 389060 from Patent EP1572962.
JD336065 - Sequence 317089 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000223862.1, NM_006911, P04808, Q99936, Q9UQJ1, REL1_HUMAN, uc317dhw.1, uc317dhw.2
UCSC ID: ENST00000223862.2_7
RefSeq Accession: NM_006911.4
Protein: P04808 (aka REL1_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.