ID:RMD3_HUMAN DESCRIPTION: RecName: Full=Regulator of microtubule dynamics protein 3; Short=RMD-3; Short=hRMD-3; AltName: Full=Cerebral protein 10; AltName: Full=Protein FAM82A2; AltName: Full=Protein FAM82C; AltName: Full=Protein tyrosine phosphatase-interacting protein 51; AltName: Full=TCPTP-interacting protein 51; FUNCTION: Involved in cellular calcium homeostasis regulation. May participate in differentiation and apoptosis of keratinocytes. Overexpression induces apoptosis. SUBUNIT: Interacts with PTPN2. Interacts with microtubules. Interacts with VAPB. INTERACTION: P61981:YWHAG; NbExp=2; IntAct=EBI-1056589, EBI-359832; SUBCELLULAR LOCATION: Mitochondrion membrane; Single-pass membrane protein. Mitochondrion outer membrane. Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=In interphase localizes in the cytoplasm, and during mitosis localizes to the spindle microtubules and spindle poles. TISSUE SPECIFICITY: Present at high level in epidermis and seminiferous epithelium: while basal cells in the epidermis and spermatogonia show no perceptible amount, keratinocytes of suprabasal layers and differentiating first-order spermatocytes up to spermatids exhibit high expression. In skeletal muscle, its presence is restricted to fibers of the fast twitch type. In surface epithelia containing ciliated cells, it is associated with the microtubular structures responsible for ciliary movement. Also present in specific structures of the central nervous system such as neurons of the hippocampal region, ganglion cells of the autonomic nervous system, and axons of the peripheral nervous system (at protein level). Widely expressed. INDUCTION: By EGF, TGFB1, retinoic acid-and 1,25-dihydroxyvitamin D(3). DOMAIN: The transmembrane region is required for mitochondrial localization. SIMILARITY: Belongs to the FAM82/RMD family. SEQUENCE CAUTION: Sequence=BAB15298.1; Type=Erroneous termination; Positions=453; Note=Translated as Glu; Sequence=BAC85554.1; Type=Frameshift; Positions=383;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q96TC7
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AK090731 - Homo sapiens cDNA FLJ33412 fis, clone BRACE2019519. BC008970 - Homo sapiens family with sequence similarity 82, member A2, mRNA (cDNA clone IMAGE:3160413), partial cds. AK025963 - Homo sapiens cDNA: FLJ22310 fis, clone HRC05110. BC063844 - Homo sapiens family with sequence similarity 82, member A2, mRNA (cDNA clone MGC:74996 IMAGE:6527521), complete cds. AY358793 - Homo sapiens clone DNA139686 SRLG3122 (UNQ3122) mRNA, complete cds. AK097286 - Homo sapiens cDNA FLJ39967 fis, clone SPLEN2027488, highly similar to Homo sapiens family with sequence similarity 82, member C (FAM82C), mRNA. AK092058 - Homo sapiens cDNA FLJ34739 fis, clone MESAN2008679, highly similar to Homo sapiens family with sequence similarity 82, member C (FAM82C), mRNA. AK001441 - Homo sapiens cDNA FLJ10579 fis, clone NT2RP2003446. AK123192 - Homo sapiens cDNA FLJ41198 fis, clone BRACE2046251, highly similar to Homo sapiens hucep-10 mRNA for cerebral protein-10. AK123282 - Homo sapiens cDNA FLJ41288 fis, clone BRAMY2038832, highly similar to Homo sapiens family with sequence similarity 82, member C (FAM82C), mRNA. JD255502 - Sequence 236526 from Patent EP1572962. JD289573 - Sequence 270597 from Patent EP1572962. JD098934 - Sequence 79958 from Patent EP1572962. JD173009 - Sequence 154033 from Patent EP1572962. JD052901 - Sequence 33925 from Patent EP1572962. JD086669 - Sequence 67693 from Patent EP1572962. HQ447480 - Synthetic construct Homo sapiens clone IMAGE:100070810; CCSB014331_01 family with sequence similarity 82, member C (FAM82C) gene, encodes complete protein. KJ894149 - Synthetic construct Homo sapiens clone ccsbBroadEn_03543 FAM82A2 gene, encodes complete protein. AB000782 - Homo sapiens hucep-10 mRNA for cerebral protein-10, complete cds. AB590829 - Synthetic construct DNA, clone: pFN21AE1933, Homo sapiens FAM82A2 gene for family with sequence similarity 82, member A2, without stop codon, in Flexi system. CU687834 - Synthetic construct Homo sapiens gateway clone IMAGE:100022828 5' read FAM82C mRNA. JD186961 - Sequence 167985 from Patent EP1572962. JD422016 - Sequence 403040 from Patent EP1572962. JD065174 - Sequence 46198 from Patent EP1572962.
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
