Human Gene RMND5B (ENST00000313386.9_4) from GENCODE V47lift37
  Description: required for meiotic nuclear division 5 homolog B, transcript variant 2 (from RefSeq NM_022762.5)
Gencode Transcript: ENST00000313386.9_4
Gencode Gene: ENSG00000145916.19_11
Transcript (Including UTRs)
   Position: hg19 chr5:177,558,015-177,577,569 Size: 19,555 Total Exon Count: 11 Strand: +
Coding Region
   Position: hg19 chr5:177,565,121-177,575,033 Size: 9,913 Coding Exon Count: 9 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr5:177,558,015-177,577,569)mRNA (may differ from genome)Protein (393 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MGIPubMedUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: RMD5B_HUMAN
DESCRIPTION: RecName: Full=Protein RMD5 homolog B;
SIMILARITY: Contains 1 CTLH domain.
SIMILARITY: Contains 1 LisH domain.
SEQUENCE CAUTION: Sequence=BAB15303.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 49.72 RPKM in Testis
Total median expression: 546.12 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -105.70193-0.548 Picture PostScript Text
3' UTR -900.802536-0.355 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR013144 - CRA_dom
IPR024964 - CTLH/CRA
IPR006595 - CTLH_C
IPR006594 - LisH_dimerisation
IPR013083 - Znf_RING/FYVE/PHD

Pfam Domains:
PF10607 - CTLH/CRA C-terminal to LisH motif domain
PF13445 - RING-type zinc-finger

SCOP Domains:
57850 - RING/U-box

ModBase Predicted Comparative 3D Structure on Q96G75
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
  Ensembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004842 ubiquitin-protein transferase activity

Biological Process:
GO:0016567 protein ubiquitination
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process

Cellular Component:
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0034657 GID complex


-  Descriptions from all associated GenBank mRNAs
  AK093481 - Homo sapiens cDNA FLJ36162 fis, clone TESTI2025920.
AK094065 - Homo sapiens cDNA FLJ36746 fis, clone UTERU2016757.
AX748156 - Sequence 1681 from Patent EP1308459.
AX748436 - Sequence 1961 from Patent EP1308459.
AK125337 - Homo sapiens cDNA FLJ43347 fis, clone NT2RI3008697.
BC009911 - Homo sapiens required for meiotic nuclear division 5 homolog B (S. cerevisiae), mRNA (cDNA clone MGC:2688 IMAGE:2820100), complete cds.
DQ494789 - Homo sapiens RMND5B mRNA, complete cds.
LF384723 - JP 2014500723-A/192226: Polycomb-Associated Non-Coding RNAs.
AL713670 - Homo sapiens mRNA; cDNA DKFZp727A111 (from clone DKFZp727A111).
EU831502 - Synthetic construct Homo sapiens clone HAIB:100066531; DKFZo004A0818 required for meiotic nuclear division 5 homolog B (S. cerevisiae) protein (RMND5B) gene, encodes complete protein.
EU831409 - Synthetic construct Homo sapiens clone HAIB:100066438; DKFZo008A0817 required for meiotic nuclear division 5 homolog B (S. cerevisiae) protein (RMND5B) gene, encodes complete protein.
AB464143 - Synthetic construct DNA, clone: pF1KB8179, Homo sapiens RMND5B gene for required for meiotic nuclear division 5 homolog B, without stop codon, in Flexi system.
AY359092 - Homo sapiens clone DNA94844 SQCC2508 (UNQ2508) mRNA, complete cds.
AK122692 - Homo sapiens cDNA FLJ16154 fis, clone BRAMY3000224.
LF325689 - JP 2014500723-A/133192: Polycomb-Associated Non-Coding RNAs.
AK025971 - Homo sapiens cDNA: FLJ22318 fis, clone HRC05303.
LF325688 - JP 2014500723-A/133191: Polycomb-Associated Non-Coding RNAs.
AL137381 - Homo sapiens mRNA; cDNA DKFZp434K0926 (from clone DKFZp434K0926).
AK093622 - Homo sapiens cDNA FLJ36303 fis, clone THYMU2004635.
AX748229 - Sequence 1754 from Patent EP1308459.
DQ597098 - Homo sapiens piRNA piR-35164, complete sequence.
LF325686 - JP 2014500723-A/133189: Polycomb-Associated Non-Coding RNAs.
LF325685 - JP 2014500723-A/133188: Polycomb-Associated Non-Coding RNAs.
JD288931 - Sequence 269955 from Patent EP1572962.
JD104835 - Sequence 85859 from Patent EP1572962.
JD341768 - Sequence 322792 from Patent EP1572962.
JD445464 - Sequence 426488 from Patent EP1572962.
JD401284 - Sequence 382308 from Patent EP1572962.
JD478790 - Sequence 459814 from Patent EP1572962.
JD176105 - Sequence 157129 from Patent EP1572962.
JD231104 - Sequence 212128 from Patent EP1572962.
JD181105 - Sequence 162129 from Patent EP1572962.
JD482528 - Sequence 463552 from Patent EP1572962.
JD345407 - Sequence 326431 from Patent EP1572962.
JD336908 - Sequence 317932 from Patent EP1572962.
JD023681 - Sequence 4705 from Patent EP1572962.
JD566839 - Sequence 547863 from Patent EP1572962.
JD300601 - Sequence 281625 from Patent EP1572962.
JD265981 - Sequence 247005 from Patent EP1572962.
JD441176 - Sequence 422200 from Patent EP1572962.
JD441177 - Sequence 422201 from Patent EP1572962.
MA620300 - JP 2018138019-A/192226: Polycomb-Associated Non-Coding RNAs.
MA561266 - JP 2018138019-A/133192: Polycomb-Associated Non-Coding RNAs.
MA561265 - JP 2018138019-A/133191: Polycomb-Associated Non-Coding RNAs.
MA561263 - JP 2018138019-A/133189: Polycomb-Associated Non-Coding RNAs.
MA561262 - JP 2018138019-A/133188: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000313386.1, ENST00000313386.2, ENST00000313386.3, ENST00000313386.4, ENST00000313386.5, ENST00000313386.6, ENST00000313386.7, ENST00000313386.8, NM_022762, Q1HE27, Q6UVY7, Q96G75, Q9H6F6, RMD5B_HUMAN, uc317pkb.1, uc317pkb.2, UNQ2508/PRO5996
UCSC ID: ENST00000313386.9_4
RefSeq Accession: NM_022762.5
Protein: Q96G75 (aka RMD5B_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.