Human Gene RNF213 (ENST00000582970.6_6) from GENCODE V47lift37
  Description: ring finger protein 213, transcript variant 3 (from RefSeq NM_001256071.3)
Gencode Transcript: ENST00000582970.6_6
Gencode Gene: ENSG00000173821.20_13
Transcript (Including UTRs)
   Position: hg19 chr17:78,234,651-78,372,594 Size: 137,944 Total Exon Count: 68 Strand: +
Coding Region
   Position: hg19 chr17:78,237,481-78,367,298 Size: 129,818 Coding Exon Count: 67 

Page IndexSequence and LinksPrimersMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureOther SpeciesmRNA DescriptionsOther Names
Model InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr17:78,234,651-78,372,594)mRNA (may differ from genome)Protein (5207 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: RNF213
Diseases sorted by gene-association score: moyamoya disease 2* (1014), moyamoya disease* (96), anaplastic large cell lymphoma (31), cerebral arterial disease (19), inflammatory myofibroblastic tumor (11), fibromuscular dysplasia (10), cerebral atherosclerosis (6), lymphoma (6), hemiplegia (5)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 23.27 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 395.34 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -54.30159-0.342 Picture PostScript Text
3' UTR -1682.105296-0.318 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Descriptions from all associated GenBank mRNAs
  KJ899362 - Synthetic construct Homo sapiens clone ccsbBroadEn_08756 RNF213 gene, encodes complete protein.
KJ904840 - Synthetic construct Homo sapiens clone ccsbBroadEn_14234 RNF213 gene, encodes complete protein.
AB537889 - Homo sapiens mystr mRNA for mysterin, complete cds.
BC036891 - Homo sapiens KIAA1618, mRNA (cDNA clone MGC:46622 IMAGE:5501834), complete cds.
AL832920 - Homo sapiens mRNA; cDNA DKFZp762N1115 (from clone DKFZp762N1115).
BC040341 - Homo sapiens KIAA1618, mRNA (cDNA clone MGC:9929 IMAGE:3873001), complete cds.
AF397204 - Homo sapiens ALO17 mRNA, partial cds; alternatively spliced.
AF397205 - Homo sapiens ALO17 variant 1 mRNA, partial cds; alternatively spliced.
CU691854 - Synthetic construct Homo sapiens gateway clone IMAGE:100020586 5' read KIAA1618 mRNA.
JD089907 - Sequence 70931 from Patent EP1572962.
JD460653 - Sequence 441677 from Patent EP1572962.
JD475375 - Sequence 456399 from Patent EP1572962.
JD453860 - Sequence 434884 from Patent EP1572962.
AB046838 - Homo sapiens mRNA for KIAA1618 protein, partial cds.
AK023113 - Homo sapiens cDNA FLJ13051 fis, clone NT2RP3001447.
DQ599822 - Homo sapiens piRNA piR-37888, complete sequence.
JD019567 - Sequence 591 from Patent EP1572962.
JD021971 - Sequence 2995 from Patent EP1572962.
JD023113 - Sequence 4137 from Patent EP1572962.
JD020236 - Sequence 1260 from Patent EP1572962.
JD027829 - Sequence 8853 from Patent EP1572962.
AK127914 - Homo sapiens cDNA FLJ46021 fis, clone SPLEN2021231.
BC172594 - Synthetic construct Homo sapiens clone IMAGE:100069288, MGC:199299 ring finger protein 213 (RNF213) mRNA, encodes complete protein.
DQ571847 - Homo sapiens piRNA piR-31959, complete sequence.
DQ591276 - Homo sapiens piRNA piR-58388, complete sequence.
BX647946 - Homo sapiens mRNA; cDNA DKFZp686C2251 (from clone DKFZp686C2251).
AK129927 - Homo sapiens cDNA FLJ26417 fis, clone KDN00457.
LF328570 - JP 2014500723-A/136073: Polycomb-Associated Non-Coding RNAs.
LF328571 - JP 2014500723-A/136074: Polycomb-Associated Non-Coding RNAs.
AK127358 - Homo sapiens cDNA FLJ45432 fis, clone BRHIP3039592.
BX640932 - Homo sapiens mRNA; cDNA DKFZp686D12123 (from clone DKFZp686D12123).
JD455820 - Sequence 436844 from Patent EP1572962.
JD468809 - Sequence 449833 from Patent EP1572962.
JD070877 - Sequence 51901 from Patent EP1572962.
JD095049 - Sequence 76073 from Patent EP1572962.
JD288027 - Sequence 269051 from Patent EP1572962.
JD419722 - Sequence 400746 from Patent EP1572962.
JD045989 - Sequence 27013 from Patent EP1572962.
AK074030 - Homo sapiens mRNA for FLJ00039 protein.
AL833201 - Homo sapiens mRNA; cDNA DKFZp667E236 (from clone DKFZp667E236).
AB046774 - Homo sapiens mRNA for KIAA1554 protein, partial cds.
JD251542 - Sequence 232566 from Patent EP1572962.
BC110403 - Homo sapiens ring finger protein 213, mRNA (cDNA clone IMAGE:5574233), with apparent retained intron.
AK025676 - Homo sapiens cDNA: FLJ22023 fis, clone HEP08456.
AK025914 - Homo sapiens cDNA: FLJ22261 fis, clone HRC02989.
DQ596906 - Homo sapiens piRNA piR-34972, complete sequence.
BC032220 - Homo sapiens ring finger protein 213, mRNA (cDNA clone IMAGE:5203963), complete cds.
AK023871 - Homo sapiens cDNA FLJ13809 fis, clone THYRO1000270.
CU689300 - Synthetic construct Homo sapiens gateway clone IMAGE:100019726 5' read RNF213 mRNA.
AK026038 - Homo sapiens cDNA: FLJ22385 fis, clone HRC07610.
AL161961 - Homo sapiens mRNA; cDNA DKFZp761N07121 (from clone DKFZp761N07121).
JD181744 - Sequence 162768 from Patent EP1572962.
JD431323 - Sequence 412347 from Patent EP1572962.
DQ582612 - Homo sapiens piRNA piR-32724, complete sequence.
JD235720 - Sequence 216744 from Patent EP1572962.
JD320429 - Sequence 301453 from Patent EP1572962.
JD113385 - Sequence 94409 from Patent EP1572962.
JD048145 - Sequence 29169 from Patent EP1572962.
JD069631 - Sequence 50655 from Patent EP1572962.
JD513076 - Sequence 494100 from Patent EP1572962.
JD513077 - Sequence 494101 from Patent EP1572962.
DQ601203 - Homo sapiens piRNA piR-39269, complete sequence.
JD303652 - Sequence 284676 from Patent EP1572962.
JD524011 - Sequence 505035 from Patent EP1572962.
JD235650 - Sequence 216674 from Patent EP1572962.
JD087220 - Sequence 68244 from Patent EP1572962.
JD317677 - Sequence 298701 from Patent EP1572962.
JD316019 - Sequence 297043 from Patent EP1572962.
JD360298 - Sequence 341322 from Patent EP1572962.
JD464637 - Sequence 445661 from Patent EP1572962.
JD186489 - Sequence 167513 from Patent EP1572962.
JD326357 - Sequence 307381 from Patent EP1572962.
JD079767 - Sequence 60791 from Patent EP1572962.
JD116080 - Sequence 97104 from Patent EP1572962.
JD332560 - Sequence 313584 from Patent EP1572962.
JD080554 - Sequence 61578 from Patent EP1572962.
JD275133 - Sequence 256157 from Patent EP1572962.
JD320807 - Sequence 301831 from Patent EP1572962.
JD273237 - Sequence 254261 from Patent EP1572962.
JD553237 - Sequence 534261 from Patent EP1572962.
JD122672 - Sequence 103696 from Patent EP1572962.
JD225863 - Sequence 206887 from Patent EP1572962.
JD347639 - Sequence 328663 from Patent EP1572962.
JD174809 - Sequence 155833 from Patent EP1572962.
JD450775 - Sequence 431799 from Patent EP1572962.
JD090325 - Sequence 71349 from Patent EP1572962.
JD540081 - Sequence 521105 from Patent EP1572962.
JD297879 - Sequence 278903 from Patent EP1572962.
JD263866 - Sequence 244890 from Patent EP1572962.
JD174112 - Sequence 155136 from Patent EP1572962.
JD062616 - Sequence 43640 from Patent EP1572962.
JD106490 - Sequence 87514 from Patent EP1572962.
JD162772 - Sequence 143796 from Patent EP1572962.
JD043572 - Sequence 24596 from Patent EP1572962.
JD109060 - Sequence 90084 from Patent EP1572962.
JD156702 - Sequence 137726 from Patent EP1572962.
JD269233 - Sequence 250257 from Patent EP1572962.
JD163190 - Sequence 144214 from Patent EP1572962.
JD440083 - Sequence 421107 from Patent EP1572962.
JD536267 - Sequence 517291 from Patent EP1572962.
JD235582 - Sequence 216606 from Patent EP1572962.
JD095168 - Sequence 76192 from Patent EP1572962.
JD129236 - Sequence 110260 from Patent EP1572962.
JD156102 - Sequence 137126 from Patent EP1572962.
JD357049 - Sequence 338073 from Patent EP1572962.
JD411685 - Sequence 392709 from Patent EP1572962.
JD323024 - Sequence 304048 from Patent EP1572962.
JD472594 - Sequence 453618 from Patent EP1572962.
JD199638 - Sequence 180662 from Patent EP1572962.
JD502119 - Sequence 483143 from Patent EP1572962.
MA564147 - JP 2018138019-A/136073: Polycomb-Associated Non-Coding RNAs.
MA564148 - JP 2018138019-A/136074: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: A0A0A0MTR7, A0A0A0MTR7_HUMAN, ENST00000582970.1, ENST00000582970.2, ENST00000582970.3, ENST00000582970.4, ENST00000582970.5, NM_001256071, RNF213 , uc326lva.1, uc326lva.2
UCSC ID: ENST00000582970.6_6
RefSeq Accession: NM_001256071.3

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.