Human Gene RNF24 (ENST00000358395.11_7) from GENCODE V47lift37

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Description: ring finger protein 24, transcript variant 4 (from RefSeq NM_001321749.2)
Gencode Transcript: ENST00000358395.11_7
Gencode Gene: ENSG00000101236.17_9
Transcript (Including UTRs)
Position: hg19 chr20:3,907,958-3,996,205 Size: 88,248 Total Exon Count: 6 Strand: -
Coding Region
Position: hg19 chr20:3,914,710-3,944,664 Size: 29,955 Coding Exon Count: 5

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr20:3,907,958-3,996,205)			mRNA (may differ from genome)		Protein (148 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	MGI	OMIM	PubMed	UniProtKB	Wikipedia
BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: RNF24_HUMAN DESCRIPTION: RecName: Full=RING finger protein 24; FUNCTION: May play a role in TRPCs intracellular trafficking. SUBUNIT: Interacts with TRPC1, TRPC3, TRPC4, TRPC5, TRPC6 and TRPC7. SUBCELLULAR LOCATION: Golgi apparatus membrane; Single-pass membrane protein. SIMILARITY: Contains 1 RING-type zinc finger.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D000082 Acetaminophen D016572 Cyclosporine D004041 Dietary Fats D004147 Dioxins D011794 Quercetin D012906 Smoke D013749 Tetrachlorodibenzodioxin C006418 adrenocorticotropin zinc C006632 arsenic trioxide C044887 beta-methylcholine more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 35.20 RPKM in Whole Blood Total median expression: 320.80 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-49.00	129	-0.380	Picture	PostScript	Text
3' UTR	-2373.70	6752	-0.352	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR001841 - Znf_RING
IPR013083 - Znf_RING/FYVE/PHD

Pfam Domains:
PF00097 - Zinc finger, C3HC4 type (RING finger)
PF12678 - RING-H2 zinc finger domain
PF13445 - RING-type zinc-finger
PF13639 - Ring finger domain
PF13923 - Zinc finger, C3HC4 type (RING finger)
PF14634 - zinc-RING finger domain
PF17123 - RING-like zinc finger

SCOP Domains:
57850 - RING/U-box
57903 - FYVE/PHD zinc finger

Protein Data Bank (PDB) 3-D Structure
MuPIT help

2EP4 - NMR MuPIT

ModBase Predicted Comparative 3D Structure on Q9Y225


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details
Gene Sorter

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0005515 protein binding GO:0008270 zinc ion binding GO:0046872 metal ion binding GO:0061630 ubiquitin protein ligase activity Biological Process: GO:0000209 protein polyubiquitination GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process Cellular Component: GO:0000139 Golgi membrane GO:0005794 Golgi apparatus GO:0016020 membrane GO:0016021 integral component of membrane

Descriptions from all associated GenBank mRNAs


	BC039584 - Homo sapiens ring finger protein 24, mRNA (cDNA clone MGC:48754 IMAGE:5214313), complete cds. AL096778 - Novel human mRNA from chromosome 20, similar to SW:GOLI_DROME Q06003 GOLIATH PROTEIN. BC000213 - Homo sapiens ring finger protein 24, mRNA (cDNA clone MGC:1815 IMAGE:2958640), complete cds. BC003141 - Homo sapiens ring finger protein 24, mRNA (cDNA clone IMAGE:2958640), ** WARNING: chimeric clone **. KJ893261 - Synthetic construct Homo sapiens clone ccsbBroadEn_02655 RNF24 gene, encodes complete protein. BT007406 - Homo sapiens ring finger protein 24 mRNA, complete cds. CU674090 - Synthetic construct Homo sapiens gateway clone IMAGE:100017930 5' read RNF24 mRNA. AB527913 - Synthetic construct DNA, clone: pF1KB0933, Homo sapiens RNF24 gene for ring finger protein 24, without stop codon, in Flexi system. BX647619 - Homo sapiens mRNA; cDNA DKFZp313P2237 (from clone DKFZp313P2237). LF349599 - JP 2014500723-A/157102: Polycomb-Associated Non-Coding RNAs. JD344870 - Sequence 325894 from Patent EP1572962. JD502284 - Sequence 483308 from Patent EP1572962. JD187102 - Sequence 168126 from Patent EP1572962. JD270741 - Sequence 251765 from Patent EP1572962. JD536891 - Sequence 517915 from Patent EP1572962. JD546940 - Sequence 527964 from Patent EP1572962. JD163525 - Sequence 144549 from Patent EP1572962. JD200840 - Sequence 181864 from Patent EP1572962. JD107636 - Sequence 88660 from Patent EP1572962. JD264735 - Sequence 245759 from Patent EP1572962. JD071865 - Sequence 52889 from Patent EP1572962. JD518951 - Sequence 499975 from Patent EP1572962. JD384807 - Sequence 365831 from Patent EP1572962. JD456926 - Sequence 437950 from Patent EP1572962. JD135702 - Sequence 116726 from Patent EP1572962. JD455061 - Sequence 436085 from Patent EP1572962. JD221877 - Sequence 202901 from Patent EP1572962. JD411922 - Sequence 392946 from Patent EP1572962. JD036734 - Sequence 17758 from Patent EP1572962. JD329115 - Sequence 310139 from Patent EP1572962. JD522283 - Sequence 503307 from Patent EP1572962. JD070834 - Sequence 51858 from Patent EP1572962. JD319327 - Sequence 300351 from Patent EP1572962. JD319326 - Sequence 300350 from Patent EP1572962. JD453096 - Sequence 434120 from Patent EP1572962. JD074938 - Sequence 55962 from Patent EP1572962. JD125422 - Sequence 106446 from Patent EP1572962. JD395713 - Sequence 376737 from Patent EP1572962. JD459748 - Sequence 440772 from Patent EP1572962. JD069568 - Sequence 50592 from Patent EP1572962. JD069567 - Sequence 50591 from Patent EP1572962. JD535428 - Sequence 516452 from Patent EP1572962. DQ594293 - Homo sapiens piRNA piR-60405, complete sequence. DQ575968 - Homo sapiens piRNA piR-44080, complete sequence. AL079313 - Homo sapiens mRNA full length insert cDNA clone EUROIMAGE 566628. JD418836 - Sequence 399860 from Patent EP1572962. AF151081 - Homo sapiens HSPC247 mRNA, complete cds. JD521476 - Sequence 502500 from Patent EP1572962. JD132667 - Sequence 113691 from Patent EP1572962. JD167540 - Sequence 148564 from Patent EP1572962. JD127337 - Sequence 108361 from Patent EP1572962. JD060066 - Sequence 41090 from Patent EP1572962. JD472660 - Sequence 453684 from Patent EP1572962. JD108506 - Sequence 89530 from Patent EP1572962. JD210705 - Sequence 191729 from Patent EP1572962. JD153796 - Sequence 134820 from Patent EP1572962. JD362453 - Sequence 343477 from Patent EP1572962. JD236485 - Sequence 217509 from Patent EP1572962. JD488246 - Sequence 469270 from Patent EP1572962. JD390907 - Sequence 371931 from Patent EP1572962. JD241519 - Sequence 222543 from Patent EP1572962. JD118273 - Sequence 99297 from Patent EP1572962. MA585176 - JP 2018138019-A/157102: Polycomb-Associated Non-Coding RNAs.

Other Names for This Gene


	Alternate Gene Symbols: D3DVZ2, D3DVZ3, ENST00000358395.1, ENST00000358395.10, ENST00000358395.2, ENST00000358395.3, ENST00000358395.4, ENST00000358395.5, ENST00000358395.6, ENST00000358395.7, ENST00000358395.8, ENST00000358395.9, NM_001321749, Q9UMH1, Q9Y225, RNF24_HUMAN, uc318anp.1, uc318anp.2 UCSC ID: ENST00000358395.11_7 RefSeq Accession: NM_001134337.3 Protein: Q9Y225 (aka RNF24_HUMAN or RN24_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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