ID:RNF41_HUMAN DESCRIPTION: RecName: Full=E3 ubiquitin-protein ligase NRDP1; EC=6.3.2.-; AltName: Full=RING finger protein 41; FUNCTION: Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Polyubiquitinates MYD88 and Negatively regulates MYD88-dependent production of proinflammatory cytokines but can promote TRIF-dependent production of type I interferon. Promotes also activation of TBK1 and IRF3. Involved in the ubiquitination of erythropoietin (EPO) and interleukin-3 (IL- 3) receptors. Thus, through maintaining basal levels of cytokine receptors, RNF41 is involved in the control of hematopoietic progenitor cell differentiation into myeloerythroid lineages (By similarity). Contributes to the maintenance of steady-state ERBB3 levels by mediating its growth factor-independent degradation. Involved in the degradation of the inhibitor of apoptosis BIRC6 and thus is an important regulator of cell death by promoting apoptosis. Acts also as a PARK2 modifier that accelerates its degradation, resulting in a reduction of PARK2 activity, influencing the balance of intracellular redox state. PATHWAY: Protein modification; protein ubiquitination. SUBUNIT: Interacts with USP8, ERBB3, PARK2 and BIRC6. Interacts with CSF2RB, EPOR, IL3RA, MYD88 and TBK1 (By similarity). TISSUE SPECIFICITY: Detected in ovary, testis and prostate. PTM: Autoubiquitinated. Autoubiquitination leads to proteasomal degradation. Deubiquitinated by USP8 to get stabilized which induces apoptosis. SIMILARITY: Contains 1 RING-type zinc finger. SIMILARITY: Contains 1 SIAH-type zinc finger. SEQUENCE CAUTION: Sequence=AAG01988.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9H4P4
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000209 protein polyubiquitination GO:0006914 autophagy GO:0006915 apoptotic process GO:0008285 negative regulation of cell proliferation GO:0010468 regulation of gene expression GO:0010498 proteasomal protein catabolic process GO:0016567 protein ubiquitination GO:0030336 negative regulation of cell migration GO:0043408 regulation of MAPK cascade GO:0045619 regulation of lymphocyte differentiation GO:0045637 regulation of myeloid cell differentiation GO:0045732 positive regulation of protein catabolic process GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051865 protein autoubiquitination GO:0051896 regulation of protein kinase B signaling GO:0097191 extrinsic apoptotic signaling pathway GO:1901525 negative regulation of macromitophagy GO:2000114 regulation of establishment of cell polarity GO:2000377 regulation of reactive oxygen species metabolic process GO:2000379 positive regulation of reactive oxygen species metabolic process
Cellular Component: GO:0005829 cytosol GO:0048471 perinuclear region of cytoplasm GO:0071782 endoplasmic reticulum tubular network
Descriptions from all associated GenBank mRNAs
JD542832 - Sequence 523856 from Patent EP1572962. JD542831 - Sequence 523855 from Patent EP1572962. JD140131 - Sequence 121155 from Patent EP1572962. JD538350 - Sequence 519374 from Patent EP1572962. JD538349 - Sequence 519373 from Patent EP1572962. JD100926 - Sequence 81950 from Patent EP1572962. JD542830 - Sequence 523854 from Patent EP1572962. JD542829 - Sequence 523853 from Patent EP1572962. JD497758 - Sequence 478782 from Patent EP1572962. JD222902 - Sequence 203926 from Patent EP1572962. JD142556 - Sequence 123580 from Patent EP1572962. AL080105 - Homo sapiens mRNA; cDNA DKFZp566H093 (from clone DKFZp566H093). AF077599 - Homo sapiens hypothetical SBBI03 protein mRNA, complete cds. JD234896 - Sequence 215920 from Patent EP1572962. JD292516 - Sequence 273540 from Patent EP1572962. JD463624 - Sequence 444648 from Patent EP1572962. JD053682 - Sequence 34706 from Patent EP1572962. JD078161 - Sequence 59185 from Patent EP1572962. JD146015 - Sequence 127039 from Patent EP1572962. JD045103 - Sequence 26127 from Patent EP1572962. JD560138 - Sequence 541162 from Patent EP1572962. JD066534 - Sequence 47558 from Patent EP1572962. JD193037 - Sequence 174061 from Patent EP1572962. JD537479 - Sequence 518503 from Patent EP1572962. JD048684 - Sequence 29708 from Patent EP1572962. JD037028 - Sequence 18052 from Patent EP1572962. JD158296 - Sequence 139320 from Patent EP1572962. BC032637 - Homo sapiens ring finger protein 41, mRNA (cDNA clone MGC:45228 IMAGE:5496849), complete cds. BC095418 - Homo sapiens ring finger protein 41, mRNA (cDNA clone IMAGE:30341882). BC036267 - Homo sapiens ring finger protein 41, mRNA (cDNA clone IMAGE:4155448). BC024284 - Homo sapiens ring finger protein 41, mRNA (cDNA clone IMAGE:4304153). AY007109 - Homo sapiens clone TCCCTA00027 mRNA sequence. BC011626 - Homo sapiens cDNA clone IMAGE:3958136, containing frame-shift errors. JD146896 - Sequence 127920 from Patent EP1572962. JD197452 - Sequence 178476 from Patent EP1572962. JD155121 - Sequence 136145 from Patent EP1572962. JD325124 - Sequence 306148 from Patent EP1572962. JD086178 - Sequence 67202 from Patent EP1572962. JD133316 - Sequence 114340 from Patent EP1572962. JD043382 - Sequence 24406 from Patent EP1572962. JD449799 - Sequence 430823 from Patent EP1572962. JD186778 - Sequence 167802 from Patent EP1572962. AK300752 - Homo sapiens cDNA FLJ50872 complete cds, highly similar to RING finger protein 41. JD309462 - Sequence 290486 from Patent EP1572962. JD064704 - Sequence 45728 from Patent EP1572962. JD237783 - Sequence 218807 from Patent EP1572962. AK304576 - Homo sapiens cDNA FLJ51733 complete cds, highly similar to RING finger protein 41. JD434128 - Sequence 415152 from Patent EP1572962. JD354932 - Sequence 335956 from Patent EP1572962. JD542332 - Sequence 523356 from Patent EP1572962. AK314811 - Homo sapiens cDNA, FLJ95687. EU446758 - Synthetic construct Homo sapiens clone IMAGE:100069890; IMAGE:100011967; FLH257064.01L ring finger protein 41 (RNF41) gene, encodes complete protein. KJ892952 - Synthetic construct Homo sapiens clone ccsbBroadEn_02346 RNF41 gene, encodes complete protein. AB527902 - Synthetic construct DNA, clone: pF1KB0912, Homo sapiens RNF41 gene for ring finger protein 41, without stop codon, in Flexi system. CU689456 - Synthetic construct Homo sapiens gateway clone IMAGE:100020742 5' read RNF41 mRNA. JD022884 - Sequence 3908 from Patent EP1572962. JD025250 - Sequence 6274 from Patent EP1572962. JD032264 - Sequence 13288 from Patent EP1572962. JD333355 - Sequence 314379 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q9H4P4 (Reactome details) participates in the following event(s):
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
