ID:ROBO3_HUMAN DESCRIPTION: RecName: Full=Roundabout homolog 3; AltName: Full=Roundabout-like protein 3; Flags: Precursor; FUNCTION: Thought to be involved during neural development in axonal navigation at the ventral midline of the neural tube. In spinal chord development plays a role in guiding commissural axons probably by preventing premature sensitivity to Slit proteins thus inhibiting Slit signaling through ROBO1 (By similarity). Required for hindbrain axon midline crossing. SUBUNIT: Probably interacts with SLIT2 (By similarity). SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (Potential). DISEASE: Defects in ROBO3 are a cause of familial horizontal gaze palsy with progressive scoliosis (HGPPS) [MIM:607313]. Patients show a medulla where motor and sensory projections appear uncrossed. SIMILARITY: Belongs to the immunoglobulin superfamily. ROBO family. SIMILARITY: Contains 3 fibronectin type-III domains. SIMILARITY: Contains 5 Ig-like C2-type (immunoglobulin-like) domains. WEB RESOURCE: Name=GeneReviews; URL="http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/ROBO3";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q96MS0
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
