Human Gene RPL11 (ENST00000643754.2_11) from GENCODE V47lift37
  Description: ribosomal protein L11, transcript variant 1 (from RefSeq NM_000975.5)
Gencode Transcript: ENST00000643754.2_11
Gencode Gene: ENSG00000142676.14_15
Transcript (Including UTRs)
   Position: hg19 chr1:24,018,296-24,023,325 Size: 5,030 Total Exon Count: 6 Strand: +
Coding Region
   Position: hg19 chr1:24,018,314-24,022,863 Size: 4,550 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesGeneReviewsModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:24,018,296-24,023,325)mRNA (may differ from genome)Protein (178 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: Q5VVD0_HUMAN
DESCRIPTION: SubName: Full=Ribosomal protein L11; SubName: Full=Ribosomal protein L11, isoform CRA_b; SubName: Full=cDNA, FLJ92077, Homo sapiens ribosomal protein L11 (RPL11), mRNA;
SIMILARITY: Belongs to the ribosomal protein L5P family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: RPL11
Diseases sorted by gene-association score: diamond-blackfan anemia 7* (1229), rpl11-related diamond-blackfan anemia* (500), diamond-blackfan anemia* (141), macrocytic anemia (9), pierre robin syndrome (5), congenital hypoplastic anemia (4)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR 0.00180.000 Picture PostScript Text
3' UTR -136.50462-0.295 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002132 - Ribosomal_L5
IPR020929 - Ribosomal_L5_CS
IPR022803 - Ribosomal_L5_domain

Pfam Domains:
PF00281 - Ribosomal protein L5
PF00673 - ribosomal L5P family C-terminus

SCOP Domains:
55282 - RL5-like

ModBase Predicted Comparative 3D Structure on Q5VVD0
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologGenome Browser
Gene DetailsGene Details Gene Details Gene Details
Gene SorterGene Sorter Gene Sorter Gene Sorter
 RGD   SGD
     Protein Sequence
     Alignment

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003735 structural constituent of ribosome

Biological Process:
GO:0006412 translation

Cellular Component:
GO:0005622 intracellular
GO:0005840 ribosome


-  Descriptions from all associated GenBank mRNAs
  D28357 - Homo sapiens mRNA for ribosomal protein L11, 5'UTR region.
AK311816 - Homo sapiens cDNA, FLJ92077, Homo sapiens ribosomal protein L11 (RPL11), mRNA.
BC018970 - Homo sapiens ribosomal protein L11, mRNA (cDNA clone MGC:19586 IMAGE:4337066), complete cds.
AB464157 - Synthetic construct DNA, clone: pF1KB3635, Homo sapiens RPL11 gene for ribosomal protein L11, without stop codon, in Flexi system.
AF432212 - Homo sapiens CLL-associated antigen KW-12 mRNA, partial cds.
X79234 - Homo sapiens mRNA for ribosomal protein L11.
L05092 - Homo sapiens ribosomal protein L11 mRNA, complete cds.
CU676346 - Synthetic construct Homo sapiens gateway clone IMAGE:100017551 5' read RPL11 mRNA.
DQ896712 - Synthetic construct Homo sapiens clone IMAGE:100011172; FLH199370.01L; RZPDo839B0881D ribosomal protein L11 (RPL11) gene, encodes complete protein.
EU176409 - Synthetic construct Homo sapiens clone IMAGE:100006534; FLH196813.01X; RZPDo839G04252D ribosomal protein L11 (RPL11) gene, encodes complete protein.
KJ892027 - Synthetic construct Homo sapiens clone ccsbBroadEn_01421 RPL11 gene, encodes complete protein.
KR710424 - Synthetic construct Homo sapiens clone CCSBHm_00012308 RPL11 (RPL11) mRNA, encodes complete protein.
AY871274 - Homo sapiens cell growth-inhibiting protein 34 mRNA, complete cds.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000643754.1, hCG_1739238 , NM_000975, Q5VVD0, Q5VVD0_HUMAN, RPL11 , uc328jyt.1, uc328jyt.2
UCSC ID: ENST00000643754.2_11
RefSeq Accession: NM_000975.5
Protein: Q5VVD0

-  GeneReviews for This Gene
  GeneReviews article(s) related to gene RPL11:
diamond-b (Diamond-Blackfan Anemia)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.