Human Gene RPLP2 (ENST00000321153.9_5) from GENCODE V47lift37
  Description: ribosomal protein lateral stalk subunit P2 (from RefSeq NM_001004.4)
Gencode Transcript: ENST00000321153.9_5
Gencode Gene: ENSG00000177600.10_9
Transcript (Including UTRs)
   Position: hg19 chr11:809,967-812,876 Size: 2,910 Total Exon Count: 5 Strand: +
Coding Region
   Position: hg19 chr11:810,235-812,836 Size: 2,602 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr11:809,967-812,876)mRNA (may differ from genome)Protein (115 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MGIOMIMPubMedReactomeUniProtKBWikipedia
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: RLA2_HUMAN
DESCRIPTION: RecName: Full=60S acidic ribosomal protein P2; AltName: Full=Renal carcinoma antigen NY-REN-44;
FUNCTION: Plays an important role in the elongation step of protein synthesis.
SUBUNIT: P1 and P2 exist as dimers at the large ribosomal subunit.
SIMILARITY: Belongs to the ribosomal protein L12P family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 1944.57 RPKM in Ovary
Total median expression: 42734.50 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -20.2074-0.273 Picture PostScript Text
3' UTR -2.7040-0.068 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001813 - Ribosomal_60S

Pfam Domains:
PF00428 - 60s Acidic ribosomal protein

Protein Data Bank (PDB) 3-D Structure
MuPIT help
1S4J - NMR 2JDL - X-ray 2LBF - NMR MuPIT 2W1O - NMR MuPIT


ModBase Predicted Comparative 3D Structure on P05387
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologGenome BrowserGenome Browser
Gene Details  Gene DetailsGene DetailsGene Details
Gene Sorter  Gene SorterGene SorterGene Sorter
  Ensembl WormBaseSGD
    Protein SequenceProtein Sequence
    AlignmentAlignment

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding

Biological Process:
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0002181 cytoplasmic translation
GO:0006412 translation
GO:0006413 translational initiation
GO:0006414 translational elongation
GO:0006614 SRP-dependent cotranslational protein targeting to membrane

Cellular Component:
GO:0005622 intracellular
GO:0005829 cytosol
GO:0005840 ribosome
GO:0005925 focal adhesion
GO:0016020 membrane
GO:0022625 cytosolic large ribosomal subunit
GO:0070062 extracellular exosome


-  Descriptions from all associated GenBank mRNAs
  BC005354 - Homo sapiens ribosomal protein, large, P2, mRNA (cDNA clone MGC:12453 IMAGE:4052568), complete cds.
D28411 - Homo sapiens mRNA for ribosomal phosphoprotein P2, 5'UTR region.
BC005920 - Homo sapiens ribosomal protein, large, P2, mRNA (cDNA clone MGC:14517 IMAGE:4274135), complete cds.
AK311954 - Homo sapiens cDNA, FLJ92222, Homo sapiens ribosomal protein, large P2 (RPLP2), mRNA.
AK130959 - Homo sapiens cDNA FLJ27449 fis, clone DMC05940.
M17887 - Human acidic ribosomal phosphoprotein P2 mRNA, complete cds.
BC062314 - Homo sapiens ribosomal protein, large, P2, mRNA (cDNA clone MGC:71408 IMAGE:4685028), complete cds.
BC007573 - Homo sapiens ribosomal protein, large, P2, mRNA (cDNA clone MGC:15530 IMAGE:3049240), complete cds.
AK056066 - Homo sapiens cDNA FLJ31504 fis, clone NT2NE2005804, weakly similar to 60S ACIDIC RIBOSOMAL PROTEIN P2.
KJ892048 - Synthetic construct Homo sapiens clone ccsbBroadEn_01442 RPLP2 gene, encodes complete protein.
CR542248 - Homo sapiens full open reading frame cDNA clone RZPDo834D0426D for gene RPLP2, ribosomal protein, large P2; complete cds, without stopcodon.
CR542212 - Homo sapiens full open reading frame cDNA clone RZPDo834D0425D for gene RPLP2, ribosomal protein, large P2; complete cds, incl. stopcodon.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein P05387 (Reactome details) participates in the following event(s):

R-HSA-72672 The 60S subunit joins the translation initiation complex
R-HSA-156826 Dissociation of L13a from the 60s ribosomal subunit
R-HSA-72673 Release of 40S and 60S subunits from the 80S ribosome
R-HSA-72671 eIF5B:GTP is hydrolyzed and released
R-HSA-156907 Aminoacyl-tRNA binds to the ribosome at the A-site
R-HSA-2408529 Sec-tRNA(Sec):EEFSEC:GTP binds to 80S Ribosome
R-HSA-141691 GTP bound eRF3:eRF1 complex binds the peptidyl tRNA:mRNA:80S Ribosome complex
R-HSA-156915 Translocation of ribosome by 3 bases in the 3' direction
R-HSA-141671 Polypeptide release from the eRF3-GDP:eRF1:mRNA:80S Ribosome complex
R-HSA-156912 Peptide transfer from P-site tRNA to the A-site tRNA
R-HSA-927832 UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex
R-HSA-927789 Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex
R-HSA-1799332 Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP)
R-HSA-156923 Hydrolysis of eEF1A:GTP
R-HSA-5333615 80S:Met-tRNAi:mRNA:SECISBP2:Sec-tRNA(Sec):EEFSEC:GTP is hydrolysed to 80S:Met-tRNAi:mRNA:SECISBP2:Sec and EEFSEC:GDP by EEFSEC
R-HSA-141673 GTP Hydrolysis by eRF3 bound to the eRF1:mRNA:polypeptide:80S Ribosome complex
R-HSA-927889 SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex)
R-HSA-1799329 Signal peptidase hydrolyzes signal peptide from ribosome-associated nascent protein
R-HSA-1799330 The SRP receptor binds the SRP:nascent peptide:ribosome complex
R-HSA-1799326 Signal-containing nascent peptide translocates to endoplasmic reticulum
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-156827 L13a-mediated translation
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-72737 Cap-dependent Translation Initiation
R-HSA-72613 Eukaryotic Translation Initiation
R-HSA-8868773 rRNA processing in the nucleus and cytosol
R-HSA-156902 Peptide chain elongation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-72766 Translation
R-HSA-376176 Signaling by ROBO receptors
R-HSA-192823 Viral mRNA Translation
R-HSA-72312 rRNA processing
R-HSA-156842 Eukaryotic Translation Elongation
R-HSA-2408522 Selenoamino acid metabolism
R-HSA-927802 Nonsense-Mediated Decay (NMD)
R-HSA-392499 Metabolism of proteins
R-HSA-422475 Axon guidance
R-HSA-168273 Influenza Viral RNA Transcription and Replication
R-HSA-8953854 Metabolism of RNA
R-HSA-71291 Metabolism of nitrogenous molecules
R-HSA-1266738 Developmental Biology
R-HSA-168255 Influenza Life Cycle
R-HSA-1430728 Metabolism
R-HSA-168254 Influenza Infection
R-HSA-5663205 Infectious disease
R-HSA-1643685 Disease

-  Other Names for This Gene
  Alternate Gene Symbols: D11S2243E, ENST00000321153.1, ENST00000321153.2, ENST00000321153.3, ENST00000321153.4, ENST00000321153.5, ENST00000321153.6, ENST00000321153.7, ENST00000321153.8, NM_001004, P05387, Q6FG96, RLA2_HUMAN, RPP2, uc317qzw.1, uc317qzw.2
UCSC ID: ENST00000321153.9_5
RefSeq Accession: NM_001004.4
Protein: P05387 (aka RLA2_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.