The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P23396
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0002181 cytoplasmic translation GO:0006281 DNA repair GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006412 translation GO:0006413 translational initiation GO:0006417 regulation of translation GO:0006614 SRP-dependent cotranslational protein targeting to membrane GO:0006915 apoptotic process GO:0006974 cellular response to DNA damage stimulus GO:0006979 response to oxidative stress GO:0007049 cell cycle GO:0007059 chromosome segregation GO:0010628 positive regulation of gene expression GO:0017148 negative regulation of translation GO:0031116 positive regulation of microtubule polymerization GO:0031334 positive regulation of protein complex assembly GO:0031397 negative regulation of protein ubiquitination GO:0032079 positive regulation of endodeoxyribonuclease activity GO:0032743 positive regulation of interleukin-2 production GO:0042104 positive regulation of activated T cell proliferation GO:0042769 DNA damage response, detection of DNA damage GO:0042981 regulation of apoptotic process GO:0043507 positive regulation of JUN kinase activity GO:0045738 negative regulation of DNA repair GO:0045739 positive regulation of DNA repair GO:0050862 positive regulation of T cell receptor signaling pathway GO:0051092 positive regulation of NF-kappaB transcription factor activity GO:0051225 spindle assembly GO:0051301 cell division GO:0061481 response to TNF agonist GO:0070301 cellular response to hydrogen peroxide GO:0071356 cellular response to tumor necrosis factor GO:1901224 positive regulation of NIK/NF-kappaB signaling GO:1902231 positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage GO:1902546 positive regulation of DNA N-glycosylase activity GO:1905053 positive regulation of base-excision repair GO:2001235 positive regulation of apoptotic signaling pathway GO:2001272 positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis
D28344 - Homo sapiens mRNA for ribosomal protein S3, 5'UTR region. AK130960 - Homo sapiens cDNA FLJ27450 fis, clone PNC07764. BC034149 - Homo sapiens ribosomal protein S3, mRNA (cDNA clone MGC:32779 IMAGE:4665438), complete cds. AK129794 - Homo sapiens cDNA FLJ26283 fis, clone DMC06792, highly similar to 40S ribosomal protein S3. AK313051 - Homo sapiens cDNA, FLJ93526, Homo sapiens ribosomal protein S3 (RPS3), mRNA. BC013231 - Homo sapiens ribosomal protein S3, mRNA (cDNA clone IMAGE:3462987). BC100284 - Homo sapiens ribosomal protein S3, mRNA (cDNA clone MGC:117338 IMAGE:6160514), complete cds. X55715 - Human Hums3 mRNA for 40S ribosomal protein s3. BC071917 - Homo sapiens ribosomal protein S3, mRNA (cDNA clone MGC:88599 IMAGE:6297012), complete cds. BC071669 - Homo sapiens ribosomal protein S3, mRNA (cDNA clone IMAGE:4432379), with apparent retained intron. BC003137 - Homo sapiens ribosomal protein S3, mRNA (cDNA clone MGC:3657 IMAGE:2906158), complete cds. AK223048 - Homo sapiens mRNA for ribosomal protein S3 variant, clone: KAT00103. S42658 - S3 ribosomal protein [human, colon, mRNA, 826 nt]. KJ905908 - Synthetic construct Homo sapiens clone ccsbBroadEn_15578 RPS3 gene, encodes complete protein. AB464166 - Synthetic construct DNA, clone: pF1KB3421, Homo sapiens RPS3 gene for ribosomal protein S3, without stop codon, in Flexi system. DQ896136 - Synthetic construct Homo sapiens clone IMAGE:100010596; FLH190668.01L; RZPDo839C1066D ribosomal protein S3 (RPS3) gene, encodes complete protein. DQ892888 - Synthetic construct clone IMAGE:100005518; FLH190672.01X; RZPDo839C1076D ribosomal protein S3 (RPS3) gene, encodes complete protein. KJ892051 - Synthetic construct Homo sapiens clone ccsbBroadEn_01445 RPS3 gene, encodes complete protein. CU678394 - Synthetic construct Homo sapiens gateway clone IMAGE:100018599 5' read RPS3 mRNA. U14990 - Human XP1PO ribosomal protein S3 (rpS3) mRNA, complete cds. U14991 - Human XP2NE ribosomal protein S3 (rpS3) mRNA, complete cds. U14992 - Human IMR-90 ribosomal protein S3 (rpS3) mRNA, complete cds. BC013196 - Homo sapiens, clone IMAGE:4347401, mRNA, partial cds. BC003577 - Homo sapiens, clone IMAGE:3544292, mRNA, partial cds. AB062288 - Homo sapiens OK/SW-cl.26 mRNA for IMR-90 ribosomal protein S3, complete cds. BC017103 - Homo sapiens ribosomal protein S3, mRNA (cDNA clone IMAGE:3503171), **** WARNING: chimeric clone ****. BC029981 - Homo sapiens ribosomal protein S3, mRNA (cDNA clone IMAGE:4705217). JD022222 - Sequence 3246 from Patent EP1572962. JD026177 - Sequence 7201 from Patent EP1572962. BC150501 - Homo sapiens ribosomal protein S3, mRNA (cDNA clone IMAGE:40134452), partial cds. JD035425 - Sequence 16449 from Patent EP1572962. JD031393 - Sequence 12417 from Patent EP1572962. JD026642 - Sequence 7666 from Patent EP1572962. JD022154 - Sequence 3178 from Patent EP1572962. JD025034 - Sequence 6058 from Patent EP1572962. JD025035 - Sequence 6059 from Patent EP1572962. JD025036 - Sequence 6060 from Patent EP1572962. JD027942 - Sequence 8966 from Patent EP1572962. JD214540 - Sequence 195564 from Patent EP1572962. JD110170 - Sequence 91194 from Patent EP1572962. JD151499 - Sequence 132523 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein P23396 (Reactome details) participates in the following event(s):
R-HSA-72676 eIF3 and eIF1A bind to the 40S subunit R-HSA-72673 Release of 40S and 60S subunits from the 80S ribosome R-HSA-72672 The 60S subunit joins the translation initiation complex R-HSA-72619 eIF2:GTP is hydrolyzed, eIFs are released R-HSA-72691 Formation of the 43S pre-initiation complex R-HSA-156808 Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a 'closed-loop' conformation R-HSA-157849 Formation of translation initiation complexes containing mRNA that does not circularize R-HSA-72671 eIF5B:GTP is hydrolyzed and released R-HSA-156907 Aminoacyl-tRNA binds to the ribosome at the A-site R-HSA-2408529 Sec-tRNA(Sec):EEFSEC:GTP binds to 80S Ribosome R-HSA-141691 GTP bound eRF3:eRF1 complex binds the peptidyl tRNA:mRNA:80S Ribosome complex R-HSA-156915 Translocation of ribosome by 3 bases in the 3' direction R-HSA-141671 Polypeptide release from the eRF3-GDP:eRF1:mRNA:80S Ribosome complex R-HSA-156912 Peptide transfer from P-site tRNA to the A-site tRNA R-HSA-927832 UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex R-HSA-927789 Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex R-HSA-1799332 Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) R-HSA-156923 Hydrolysis of eEF1A:GTP R-HSA-72621 Ribosomal scanning R-HSA-72697 Start codon recognition R-HSA-156823 Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA R-HSA-5333615 80S:Met-tRNAi:mRNA:SECISBP2:Sec-tRNA(Sec):EEFSEC:GTP is hydrolysed to 80S:Met-tRNAi:mRNA:SECISBP2:Sec and EEFSEC:GDP by EEFSEC R-HSA-141673 GTP Hydrolysis by eRF3 bound to the eRF1:mRNA:polypeptide:80S Ribosome complex R-HSA-927889 SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) R-HSA-1799329 Signal peptidase hydrolyzes signal peptide from ribosome-associated nascent protein R-HSA-1799330 The SRP receptor binds the SRP:nascent peptide:ribosome complex R-HSA-1799326 Signal-containing nascent peptide translocates to endoplasmic reticulum R-HSA-72689 Formation of a pool of free 40S subunits R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane R-HSA-9010553 Regulation of expression of SLITs and ROBOs R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72649 Translation initiation complex formation R-HSA-72737 Cap-dependent Translation Initiation R-HSA-8868773 rRNA processing in the nucleus and cytosol R-HSA-156902 Peptide chain elongation R-HSA-2408557 Selenocysteine synthesis R-HSA-72764 Eukaryotic Translation Termination R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-72766 Translation R-HSA-376176 Signaling by ROBO receptors R-HSA-192823 Viral mRNA Translation R-HSA-72702 Ribosomal scanning and start codon recognition R-HSA-156827 L13a-mediated translation R-HSA-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72613 Eukaryotic Translation Initiation R-HSA-72312 rRNA processing R-HSA-156842 Eukaryotic Translation Elongation R-HSA-2408522 Selenoamino acid metabolism R-HSA-927802 Nonsense-Mediated Decay (NMD) R-HSA-392499 Metabolism of proteins R-HSA-422475 Axon guidance R-HSA-168273 Influenza Viral RNA Transcription and Replication R-HSA-8953854 Metabolism of RNA R-HSA-71291 Metabolism of nitrogenous molecules R-HSA-1266738 Developmental Biology R-HSA-168255 Influenza Life Cycle R-HSA-1430728 Metabolism R-HSA-168254 Influenza Infection R-HSA-5663205 Infectious disease R-HSA-1643685 Disease
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
