Human Gene RPS8 (ENST00000396651.8_4) from GENCODE V47lift37
  Description: ribosomal protein S8 (from RefSeq NM_001012.2)
Gencode Transcript: ENST00000396651.8_4
Gencode Gene: ENSG00000142937.12_7
Transcript (Including UTRs)
   Position: hg19 chr1:45,241,212-45,244,451 Size: 3,240 Total Exon Count: 6 Strand: +
Coding Region
   Position: hg19 chr1:45,241,269-45,244,357 Size: 3,089 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:45,241,212-45,244,451)mRNA (may differ from genome)Protein (208 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedUniProtKBWikipedia
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: Q5JR94_HUMAN
DESCRIPTION: RecName: Full=40S ribosomal protein S8;
SIMILARITY: Belongs to the ribosomal protein S8e family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 1028.48 RPKM in Ovary
Total median expression: 14658.91 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -10.0057-0.175 Picture PostScript Text
3' UTR -8.7094-0.093 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001047 - Ribosomal_S8e
IPR022309 - Ribosomal_S8e/biogenesis_NSA2
IPR018283 - Ribosomal_S8e_CS

Pfam Domains:
PF01201 - Ribosomal protein S8e

ModBase Predicted Comparative 3D Structure on Q5JR94
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologGenome Browser
Gene DetailsGene Details Gene DetailsGene DetailsGene Details
Gene SorterGene Sorter Gene SorterGene SorterGene Sorter
 RGDEnsembl WormBaseSGD
     Protein Sequence
     Alignment

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding

Biological Process:
GO:0006412 translation

Cellular Component:
GO:0005622 intracellular
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0005840 ribosome
GO:0022627 cytosolic small ribosomal subunit


-  Descriptions from all associated GenBank mRNAs
  D28361 - Homo sapiens mRNA for ribosomal protein S8, 5'UTR region.
AK311854 - Homo sapiens cDNA, FLJ92120, Homo sapiens ribosomal protein S8 (RPS8), mRNA.
BC022070 - Homo sapiens cDNA clone IMAGE:4799369, containing frame-shift errors.
BC070875 - Homo sapiens ribosomal protein S8, mRNA (cDNA clone MGC:90249 IMAGE:6527505), complete cds.
CU687100 - Synthetic construct Homo sapiens gateway clone IMAGE:100022887 5' read RPS8 mRNA.
HQ447510 - Synthetic construct Homo sapiens clone IMAGE:100070849; CCSB014625_01 ribosomal protein S8 (RPS8) gene, encodes complete protein.
KJ892055 - Synthetic construct Homo sapiens clone ccsbBroadEn_01449 RPS8 gene, encodes complete protein.
AB062401 - Homo sapiens OK/SW-cl.83 mRNA for ribosomal protein S8, complete cds.
AF116700 - Homo sapiens PRO2386 mRNA, partial cds.
DL490508 - Novel nucleic acids.
LF364604 - JP 2014500723-A/172107: Polycomb-Associated Non-Coding RNAs.
BC005678 - Homo sapiens, Similar to ribosomal protein S8, clone IMAGE:3447074, mRNA, partial cds.
MA600181 - JP 2018138019-A/172107: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000396651.1, ENST00000396651.2, ENST00000396651.3, ENST00000396651.4, ENST00000396651.5, ENST00000396651.6, ENST00000396651.7, hCG_2031852 , NM_001012, Q5JR94, Q5JR94_HUMAN, RPS8 , uc318yka.1, uc318yka.2
UCSC ID: ENST00000396651.8_4
RefSeq Accession: NM_001012.2
Protein: Q5JR94

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.