ID:RRAS_HUMAN DESCRIPTION: RecName: Full=Ras-related protein R-Ras; AltName: Full=p23; Flags: Precursor; FUNCTION: Regulates the organization of the actin cytoskeleton. SUBUNIT: Interacts with PLCE1. Interacts (active GTP-bound form preferentially) with RGS14 (By similarity). INTERACTION: P16333:NCK1; NbExp=3; IntAct=EBI-968703, EBI-389883; SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side (By similarity). Note=Inner surface of plasma membrane possibly with attachment requiring acylation of the C-terminal cysteine (By similarity with RAS). SIMILARITY: Belongs to the small GTPase superfamily. Ras family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P10301
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0002521 leukocyte differentiation GO:0007165 signal transduction GO:0007265 Ras protein signal transduction GO:0030336 negative regulation of cell migration GO:0045766 positive regulation of angiogenesis GO:0051896 regulation of protein kinase B signaling GO:0060325 face morphogenesis GO:0070372 regulation of ERK1 and ERK2 cascade
BC016286 - Homo sapiens related RAS viral (r-ras) oncogene homolog, mRNA (cDNA clone MGC:9452 IMAGE:3910343), complete cds. LF207658 - JP 2014500723-A/15161: Polycomb-Associated Non-Coding RNAs. BC016318 - Homo sapiens related RAS viral (r-ras) oncogene homolog, mRNA (cDNA clone MGC:22906 IMAGE:4073829), complete cds. LF367762 - JP 2014500723-A/175265: Polycomb-Associated Non-Coding RNAs. LF213740 - JP 2014500723-A/21243: Polycomb-Associated Non-Coding RNAs. JD417209 - Sequence 398233 from Patent EP1572962. JD398994 - Sequence 380018 from Patent EP1572962. JD195434 - Sequence 176458 from Patent EP1572962. JD241174 - Sequence 222198 from Patent EP1572962. JD193488 - Sequence 174512 from Patent EP1572962. JD401157 - Sequence 382181 from Patent EP1572962. JD116054 - Sequence 97078 from Patent EP1572962. JD118081 - Sequence 99105 from Patent EP1572962. JD443608 - Sequence 424632 from Patent EP1572962. JD321190 - Sequence 302214 from Patent EP1572962. AF493920 - Homo sapiens Ras family small GTP binding protein R-Ras (RRAS) mRNA, complete cds. BT006805 - Homo sapiens related RAS viral (r-ras) oncogene homolog mRNA, complete cds. CR541944 - Homo sapiens full open reading frame cDNA clone RZPDo834A1034D for gene RRAS, related RAS viral (r-ras) oncogene homolog; complete cds, incl. stopcodon. DQ890730 - Synthetic construct clone IMAGE:100003360; FLH165529.01X; RZPDo839D06160D related RAS viral (r-ras) oncogene homolog (RRAS) gene, encodes complete protein. DQ892428 - Synthetic construct clone IMAGE:100005058; FLH186246.01X; RZPDo839C0671D related RAS viral (r-ras) oncogene homolog (RRAS) gene, encodes complete protein. DQ895642 - Synthetic construct Homo sapiens clone IMAGE:100010102; FLH186242.01L; RZPDo839C0661D related RAS viral (r-ras) oncogene homolog (RRAS) gene, encodes complete protein. CR541967 - Homo sapiens full open reading frame cDNA clone RZPDo834E0934D for gene RRAS, related RAS viral (r-ras) oncogene homolog; complete cds, without stopcodon. AB528722 - Synthetic construct DNA, clone: pF1KB6983, Homo sapiens RRAS gene for related RAS viral (r-ras) oncogene homolog, without stop codon, in Flexi system. LF207657 - JP 2014500723-A/15160: Polycomb-Associated Non-Coding RNAs. JD336909 - Sequence 317933 from Patent EP1572962. LF367757 - JP 2014500723-A/175260: Polycomb-Associated Non-Coding RNAs. JD508490 - Sequence 489514 from Patent EP1572962. JD409409 - Sequence 390433 from Patent EP1572962. MA603339 - JP 2018138019-A/175265: Polycomb-Associated Non-Coding RNAs. MA603334 - JP 2018138019-A/175260: Polycomb-Associated Non-Coding RNAs. MA443235 - JP 2018138019-A/15161: Polycomb-Associated Non-Coding RNAs. MA449317 - JP 2018138019-A/21243: Polycomb-Associated Non-Coding RNAs. MA443234 - JP 2018138019-A/15160: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein P10301 (Reactome details) participates in the following event(s):
R-HSA-399935 Inactivation of R-Ras by Sema3A-Plexin-A GAP activity R-HSA-416546 Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity R-HSA-442726 Raf activation R-HSA-399955 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-416550 Sema4D mediated inhibition of cell attachment and migration R-HSA-442742 CREB phosphorylation through the activation of Ras R-HSA-373755 Semaphorin interactions R-HSA-400685 Sema4D in semaphorin signaling R-HSA-438064 Post NMDA receptor activation events R-HSA-422475 Axon guidance R-HSA-442755 Activation of NMDA receptor and postsynaptic events R-HSA-1266738 Developmental Biology R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112315 Transmission across Chemical Synapses R-HSA-112316 Neuronal System
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
