ID:RREB1_HUMAN DESCRIPTION: RecName: Full=Ras-responsive element-binding protein 1; Short=RREB-1; AltName: Full=Finger protein in nuclear bodies; AltName: Full=Raf-responsive zinc finger protein LZ321; AltName: Full=Zinc finger motif enhancer-binding protein 1; Short=Zep-1; FUNCTION: Transcription factor that binds specifically to the RAS- responsive elements (RRE) of gene promoters. May be involved in Ras/Raf-mediated cell differentiation by enhancing calcitonin expression. Represses the angiotensinogen gene. Negatively regulates the transcriptional activity of AR. Potentiates the transcriptional activity of NEUROD1. SUBUNIT: Interacts with NEUROD1 and AR. SUBCELLULAR LOCATION: Nucleus speckle. TISSUE SPECIFICITY: Expressed in heart, placenta, lung, liver, skeletal muscle, kidney and pancreas. Not found in the brain. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family. SIMILARITY: Contains 15 C2H2-type zinc fingers. SEQUENCE CAUTION: Sequence=AAB19094.1; Type=Frameshift; Positions=908, 1350, 1383; Sequence=AAC25598.1; Type=Frameshift; Positions=1350, 1383; Sequence=AAC26118.1; Type=Frameshift; Positions=1350, 1383; Sequence=AAH42910.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAH42910.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence; Sequence=BAA23165.1; Type=Miscellaneous discrepancy; Note=Numerous sequencing errors; Sequence=CAH73521.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q92766
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding GO:0003676 nucleic acid binding GO:0003677 DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0046872 metal ion binding
Biological Process: GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006366 transcription from RNA polymerase II promoter GO:0007265 Ras protein signal transduction GO:0007275 multicellular organism development GO:0010634 positive regulation of epithelial cell migration GO:0033601 positive regulation of mammary gland epithelial cell proliferation GO:0045892 negative regulation of transcription, DNA-templated GO:0045893 positive regulation of transcription, DNA-templated GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:1900026 positive regulation of substrate adhesion-dependent cell spreading GO:1903691 positive regulation of wound healing, spreading of epidermal cells GO:2000394 positive regulation of lamellipodium morphogenesis
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
