Human Gene RRP1B (ENST00000340648.6_4) from GENCODE V47lift37
  Description: ribosomal RNA processing 1B (from RefSeq NM_015056.3)
Gencode Transcript: ENST00000340648.6_4
Gencode Gene: ENSG00000160208.13_7
Transcript (Including UTRs)
   Position: hg19 chr21:45,079,441-45,115,960 Size: 36,520 Total Exon Count: 16 Strand: +
Coding Region
   Position: hg19 chr21:45,079,546-45,113,264 Size: 33,719 Coding Exon Count: 16 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr21:45,079,441-45,115,960)mRNA (may differ from genome)Protein (758 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MGIOMIMPubMedUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: RRP1B_HUMAN
DESCRIPTION: RecName: Full=Ribosomal RNA processing protein 1 homolog B; AltName: Full=RRP1-like protein B;
INTERACTION: O15116:LSM1; NbExp=1; IntAct=EBI-372051, EBI-347619;
SUBCELLULAR LOCATION: Nucleus, nucleolus.
SIMILARITY: Belongs to the RRP1 family.
SEQUENCE CAUTION: Sequence=BAA11496.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 15.52 RPKM in Testis
Total median expression: 332.10 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -52.40105-0.499 Picture PostScript Text
3' UTR -849.602696-0.315 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR010301 - Nop52

Pfam Domains:
PF05997 - Nucleolar protein,Nop52

ModBase Predicted Comparative 3D Structure on Q14684
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologGenome BrowserGenome Browser
Gene DetailsGene Details  Gene DetailsGene Details
Gene SorterGene Sorter  Gene SorterGene Sorter
 RGD  WormBaseSGD
    Protein SequenceProtein Sequence
    AlignmentAlignment

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0001105 RNA polymerase II transcription coactivator activity
GO:0003723 RNA binding
GO:0005515 protein binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006364 rRNA processing
GO:0006366 transcription from RNA polymerase II promoter
GO:0006397 mRNA processing
GO:0006915 apoptotic process
GO:0008380 RNA splicing
GO:0010923 negative regulation of phosphatase activity
GO:0034260 negative regulation of GTPase activity
GO:0043065 positive regulation of apoptotic process
GO:0043484 regulation of RNA splicing
GO:0043923 positive regulation by host of viral transcription
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0098586 cellular response to virus

Cellular Component:
GO:0000791 euchromatin
GO:0000792 heterochromatin
GO:0001652 granular component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005730 nucleolus
GO:0005829 cytosol
GO:0030687 preribosome, large subunit precursor
GO:0030688 preribosome, small subunit precursor


-  Descriptions from all associated GenBank mRNAs
  BC028386 - Homo sapiens ribosomal RNA processing 1 homolog B (S. cerevisiae), mRNA (cDNA clone MGC:33175 IMAGE:4821672), complete cds.
BC014005 - Homo sapiens ribosomal RNA processing 1 homolog B (S. cerevisiae), mRNA (cDNA clone IMAGE:3839957), partial cds.
AK056263 - Homo sapiens cDNA FLJ31701 fis, clone NT2RI2006072.
D80001 - Homo sapiens KIAA0179 mRNA, complete cds.
AB385292 - Synthetic construct DNA, clone: pF1KA0179, Homo sapiens RRP1B gene for RRP1-like protein B, complete cds, without stop codon, in Flexi system.
JD229688 - Sequence 210712 from Patent EP1572962.
AK124620 - Homo sapiens cDNA FLJ42629 fis, clone BRACE3019055.
JD408565 - Sequence 389589 from Patent EP1572962.
JD217762 - Sequence 198786 from Patent EP1572962.
JD530039 - Sequence 511063 from Patent EP1572962.
JD459219 - Sequence 440243 from Patent EP1572962.
JD551115 - Sequence 532139 from Patent EP1572962.
JD390071 - Sequence 371095 from Patent EP1572962.
JD231173 - Sequence 212197 from Patent EP1572962.
JD193603 - Sequence 174627 from Patent EP1572962.
JD338016 - Sequence 319040 from Patent EP1572962.
JD126473 - Sequence 107497 from Patent EP1572962.
JD342680 - Sequence 323704 from Patent EP1572962.
JD168060 - Sequence 149084 from Patent EP1572962.
JD557049 - Sequence 538073 from Patent EP1572962.
DQ586046 - Homo sapiens piRNA piR-53158, complete sequence.
JD110165 - Sequence 91189 from Patent EP1572962.
JD385010 - Sequence 366034 from Patent EP1572962.
JD226568 - Sequence 207592 from Patent EP1572962.
JD220641 - Sequence 201665 from Patent EP1572962.
JD542254 - Sequence 523278 from Patent EP1572962.
JD265185 - Sequence 246209 from Patent EP1572962.
JD269109 - Sequence 250133 from Patent EP1572962.
JD102448 - Sequence 83472 from Patent EP1572962.
JD376525 - Sequence 357549 from Patent EP1572962.
JD509972 - Sequence 490996 from Patent EP1572962.
JD175345 - Sequence 156369 from Patent EP1572962.
JD244972 - Sequence 225996 from Patent EP1572962.
JD550812 - Sequence 531836 from Patent EP1572962.
JD432068 - Sequence 413092 from Patent EP1572962.
JD043311 - Sequence 24335 from Patent EP1572962.
JD305049 - Sequence 286073 from Patent EP1572962.
JD109624 - Sequence 90648 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000340648.1, ENST00000340648.2, ENST00000340648.3, ENST00000340648.4, ENST00000340648.5, KIAA0179, NM_015056, Q14684, Q8TBZ4, RRP1B_HUMAN, uc317vtb.1, uc317vtb.2
UCSC ID: ENST00000340648.6_4
RefSeq Accession: NM_015056.3
Protein: Q14684 (aka RRP1B_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.