Human Gene RSL24D1 (ENST00000260443.9_12) from GENCODE V47lift37
  Description: ribosomal L24 domain containing 1 (from RefSeq NM_016304.3)
Gencode Transcript: ENST00000260443.9_12
Gencode Gene: ENSG00000137876.11_15
Transcript (Including UTRs)
   Position: hg19 chr15:55,473,004-55,489,139 Size: 16,136 Total Exon Count: 6 Strand: -
Coding Region
   Position: hg19 chr15:55,474,350-55,489,088 Size: 14,739 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr15:55,473,004-55,489,139)mRNA (may differ from genome)Protein (163 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: RLP24_HUMAN
DESCRIPTION: RecName: Full=Probable ribosome biogenesis protein RLP24; AltName: Full=Ribosomal L24 domain-containing protein 1; AltName: Full=Ribosomal protein L24-like;
FUNCTION: Involved in the biogenesis of the 60S ribosomal subunit. Ensures the docking of GTPBP4/NOG1 to pre-60S particles (By similarity).
SUBUNIT: Associated with nucleolar and cytoplasmic pre-60S particles. At the end of biogenesis it dissociates from cytoplasmic pre-60S particles and is likely to be exchanged for its ribosomal homolog, RPL24 (By similarity).
SUBCELLULAR LOCATION: Nucleus, nucleolus.
SIMILARITY: Belongs to the ribosomal protein L24e family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: RSL24D1
Diseases sorted by gene-association score: diamond-blackfan anemia (3)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 51.39 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 1149.34 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -9.2051-0.180 Picture PostScript Text
3' UTR -293.101346-0.218 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR023442 - Ribosomal_L24e_CS
IPR023441 - Ribosomal_L24e_dom
IPR000988 - Ribosomal_L24e_rel
IPR024546 - Ribosome_biogen_RLP24
IPR011017 - TRASH

Pfam Domains:
PF01246 - Ribosomal protein L24e

SCOP Domains:
57716 - Glucocorticoid receptor-like (DNA-binding domain)

ModBase Predicted Comparative 3D Structure on Q9UHA3
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologGenome Browser
Gene DetailsGene Details Gene Details Gene Details
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 RGDEnsembl  SGD
     Protein Sequence
     Alignment

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding

Biological Process:
GO:0000027 ribosomal large subunit assembly
GO:0006412 translation
GO:0042254 ribosome biogenesis
GO:1902626 assembly of large subunit precursor of preribosome

Cellular Component:
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit


-  Descriptions from all associated GenBank mRNAs
  BC012913 - Homo sapiens ribosomal L24 domain containing 1, mRNA (cDNA clone MGC:21433 IMAGE:4514979), complete cds.
BC026266 - Homo sapiens ribosomal L24 domain containing 1, mRNA (cDNA clone MGC:22752 IMAGE:4276092), complete cds.
BC093067 - Homo sapiens ribosomal L24 domain containing 1, mRNA (cDNA clone MGC:111181 IMAGE:30419021), complete cds.
AF212226 - Homo sapiens RPL24 mRNA, complete cds.
AF060926 - Homo sapiens clone 018e04 My024 protein mRNA, complete cds.
BC008449 - Homo sapiens ribosomal L24 domain containing 1, mRNA (cDNA clone MGC:14686 IMAGE:4133589), complete cds.
BC026267 - Homo sapiens ribosomal L24 domain containing 1, mRNA (cDNA clone MGC:22753 IMAGE:4277062), complete cds.
BC016777 - Homo sapiens ribosomal L24 domain containing 1, mRNA (cDNA clone MGC:23743 IMAGE:4104810), complete cds.
BC008422 - Homo sapiens ribosomal L24 domain containing 1, mRNA (cDNA clone MGC:14573 IMAGE:4096889), complete cds.
BC009593 - Homo sapiens ribosomal L24 domain containing 1, mRNA (cDNA clone MGC:14678 IMAGE:4109097), complete cds.
BC009604 - Homo sapiens ribosomal L24 domain containing 1, mRNA (cDNA clone MGC:14750 IMAGE:4282059), complete cds.
BC016331 - Homo sapiens ribosomal L24 domain containing 1, mRNA (cDNA clone MGC:23761 IMAGE:4108672), complete cds.
BC016725 - Homo sapiens ribosomal L24 domain containing 1, mRNA (cDNA clone MGC:24451 IMAGE:4078305), complete cds.
BC008409 - Homo sapiens ribosomal L24 domain containing 1, mRNA (cDNA clone MGC:14543 IMAGE:4097130), complete cds.
BC016312 - Homo sapiens ribosomal L24 domain containing 1, mRNA (cDNA clone MGC:22728 IMAGE:4096867), complete cds.
BC005344 - Homo sapiens chromosome 15 open reading frame 15, mRNA (cDNA clone IMAGE:3930512), containing frame-shift errors.
AK055713 - Homo sapiens cDNA FLJ31151 fis, clone IMR322001541, highly similar to Probable ribosome biogenesis protein RLP24.
BC028672 - Homo sapiens ribosomal L24 domain containing 1, mRNA (cDNA clone MGC:23706 IMAGE:4092804), complete cds.
BC035995 - Homo sapiens ribosomal L24 domain containing 1, mRNA (cDNA clone MGC:32790 IMAGE:4671856), complete cds.
AF165521 - Homo sapiens ribosomal protein L30 isolog (L30) mRNA, complete cds.
JD090603 - Sequence 71627 from Patent EP1572962.
JD292014 - Sequence 273038 from Patent EP1572962.
JD109500 - Sequence 90524 from Patent EP1572962.
JD093254 - Sequence 74278 from Patent EP1572962.
AF201949 - Homo sapiens 60S ribosomal protein L30 isolog mRNA, complete cds.
BC008499 - Homo sapiens ribosomal L24 domain containing 1, mRNA (cDNA clone MGC:14835 IMAGE:4286115), complete cds.
JD280027 - Sequence 261051 from Patent EP1572962.
AB462502 - Homo sapiens TVAS3 mRNA, PBMC-based diagnostic gene marker for vasculitis.
JD551520 - Sequence 532544 from Patent EP1572962.
JD328842 - Sequence 309866 from Patent EP1572962.
BC014576 - Homo sapiens ribosomal L24 domain containing 1, mRNA (cDNA clone MGC:22835 IMAGE:3930303), complete cds.
JD302840 - Sequence 283864 from Patent EP1572962.
JD020809 - Sequence 1833 from Patent EP1572962.
JD019109 - Sequence 133 from Patent EP1572962.
JD019110 - Sequence 134 from Patent EP1572962.
CR457179 - Homo sapiens full open reading frame cDNA clone RZPDo834D108D for gene C15orf15, chromosome 15 open reading frame 15; complete cds, incl. stopcodon.
AK315431 - Homo sapiens cDNA, FLJ96487.
CU688538 - Synthetic construct Homo sapiens gateway clone IMAGE:100021810 5' read C15orf15 mRNA.
HQ448079 - Synthetic construct Homo sapiens clone IMAGE:100071459; CCSB012797_02 chromosome 15 open reading frame 15 (C15orf15) gene, encodes complete protein.
KJ898851 - Synthetic construct Homo sapiens clone ccsbBroadEn_08245 RSL24D1 gene, encodes complete protein.
KJ904747 - Synthetic construct Homo sapiens clone ccsbBroadEn_14141 RSL24D1 gene, encodes complete protein.
KJ906155 - Synthetic construct Homo sapiens clone ccsbBroadEn_15825 RSL24D1 gene, encodes complete protein.
KJ906157 - Synthetic construct Homo sapiens clone ccsbBroadEn_15827 RSL24D1 gene, encodes complete protein.
KJ906158 - Synthetic construct Homo sapiens clone ccsbBroadEn_15828 RSL24D1 gene, encodes complete protein.
KJ906159 - Synthetic construct Homo sapiens clone ccsbBroadEn_15829 RSL24D1 gene, encodes complete protein.
KJ906160 - Synthetic construct Homo sapiens clone ccsbBroadEn_15830 RSL24D1 gene, encodes complete protein.
AB463507 - Synthetic construct DNA, clone: pF1KB6821, Homo sapiens C15orf15 gene for chromosome 15 open reading frame 15, without stop codon, in Flexi system.
JD035091 - Sequence 16115 from Patent EP1572962.
KJ906156 - Synthetic construct Homo sapiens clone ccsbBroadEn_15826 RSL24D1 gene, encodes complete protein.

-  Other Names for This Gene
  Alternate Gene Symbols: B2RD72, C15orf15, ENST00000260443.1, ENST00000260443.2, ENST00000260443.3, ENST00000260443.4, ENST00000260443.5, ENST00000260443.6, ENST00000260443.7, ENST00000260443.8, My024, NM_016304, Q561V8, Q8N6S8, Q96B04, Q96C76, Q96HJ1, Q9UHA3, RLP24_HUMAN, RPL24L, uc317gkm.1, uc317gkm.2
UCSC ID: ENST00000260443.9_12
RefSeq Accession: NM_016304.3
Protein: Q9UHA3 (aka RLP24_HUMAN or RP24_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.