Human Gene RXFP3 (ENST00000330120.5_4) from GENCODE V47lift37
  Description: relaxin family peptide receptor 3 (from RefSeq NM_016568.3)
Gencode Transcript: ENST00000330120.5_4
Gencode Gene: ENSG00000182631.7_8
Transcript (Including UTRs)
   Position: hg19 chr5:33,936,491-33,939,023 Size: 2,533 Total Exon Count: 1 Strand: +
Coding Region
   Position: hg19 chr5:33,936,846-33,938,255 Size: 1,410 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr5:33,936,491-33,939,023)mRNA (may differ from genome)Protein (469 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCHuman Cortex Gene ExpressionMGIOMIMPubMedReactome
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: RL3R1_HUMAN
DESCRIPTION: RecName: Full=Relaxin-3 receptor 1; Short=RLN3 receptor 1; AltName: Full=G protein-coupled receptor SALPR; AltName: Full=G-protein coupled receptor GPCR135; AltName: Full=Relaxin family peptide receptor 3; AltName: Full=Somatostatin- and angiotensin-like peptide receptor;
FUNCTION: Receptor for RNL3/relaxin-3. Binding of the ligand inhibit cAMP accumulation.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Expressed predominantly in brain regions. Highest expression in substantia nigra and pituitary, followed by hippocampus, spinal cord, amygdala, caudate nucleus and corpus callosum, quite low level in cerebellum. In peripheral tissues, relatively high levels in adrenal glands, low levels in pancreas, salivary gland, placenta, mammary gland and testis.
SIMILARITY: Belongs to the G-protein coupled receptor 1 family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 0.10 RPKM in Brain - Hypothalamus
Total median expression: 0.43 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -133.90355-0.377 Picture PostScript Text
3' UTR -297.60768-0.388 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000276 - 7TM_GPCR_Rhodpsn
IPR000826 - Frt_met_rcpt
IPR017452 - GPCR_Rhodpsn_supfam

Pfam Domains:
PF00001 - 7 transmembrane receptor (rhodopsin family)

SCOP Domains:
81321 - Family A G protein-coupled receptor-like

ModBase Predicted Comparative 3D Structure on Q9NSD7
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004871 signal transducer activity
GO:0004930 G-protein coupled receptor activity
GO:0004966 galanin receptor activity
GO:0008528 G-protein coupled peptide receptor activity

Biological Process:
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007218 neuropeptide signaling pathway
GO:0032467 positive regulation of cytokinesis
GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway

Cellular Component:
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  D88437 - Homo sapiens mRNA for G-protein coupled receptor SALPR, complete cds.
JD169908 - Sequence 150932 from Patent EP1572962.
JD408630 - Sequence 389654 from Patent EP1572962.
JD534909 - Sequence 515933 from Patent EP1572962.
JD534910 - Sequence 515934 from Patent EP1572962.
JD128499 - Sequence 109523 from Patent EP1572962.
BC113438 - Homo sapiens relaxin/insulin-like family peptide receptor 3, mRNA (cDNA clone MGC:141998 IMAGE:8322490), complete cds.
BC113440 - Homo sapiens relaxin/insulin-like family peptide receptor 3, mRNA (cDNA clone MGC:142000 IMAGE:8322492), complete cds.
BC095526 - Homo sapiens relaxin/insulin-like family peptide receptor 3, mRNA (cDNA clone MGC:111744 IMAGE:30706560), complete cds.
JD295928 - Sequence 276952 from Patent EP1572962.
HQ258443 - Synthetic construct Homo sapiens clone IMAGE:100072872 relaxin/insulin-like family peptide receptor 3 (RXFP3) gene, encodes complete protein.
EU831899 - Synthetic construct Homo sapiens clone HAIB:100066928; DKFZo004G0622 relaxin/insulin-like family peptide receptor 3 protein (RXFP3) gene, encodes complete protein.
EU831822 - Synthetic construct Homo sapiens clone HAIB:100066851; DKFZo008G0621 relaxin/insulin-like family peptide receptor 3 protein (RXFP3) gene, encodes complete protein.
AY394501 - Homo sapiens relaxin-3 receptor-1 mRNA, complete cds.
JD419399 - Sequence 400423 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9NSD7 (Reactome details) participates in the following event(s):

R-HSA-444848 Relaxin 3 receptor 1 binds relaxin 3
R-HSA-749454 The Ligand:GPCR:Gi complex dissociates
R-HSA-749456 Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi
R-HSA-380073 Liganded Gi-activating GPCR acts as a GEF for Gi
R-HSA-444821 Relaxin receptors
R-HSA-418594 G alpha (i) signalling events
R-HSA-375276 Peptide ligand-binding receptors
R-HSA-388396 GPCR downstream signalling
R-HSA-373076 Class A/1 (Rhodopsin-like receptors)
R-HSA-372790 Signaling by GPCR
R-HSA-500792 GPCR ligand binding
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000330120.1, ENST00000330120.2, ENST00000330120.3, ENST00000330120.4, GPCR135, NM_016568, Q14DA5, Q9NSD7, RL3R1_HUMAN, RLN3R1, SALPR, uc317sws.1, uc317sws.2
UCSC ID: ENST00000330120.5_4
RefSeq Accession: NM_016568.3
Protein: Q9NSD7 (aka RL3R1_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.