Human Gene RXFP3 (ENST00000330120.5_4) from GENCODE V47lift37
Description: relaxin family peptide receptor 3 (from RefSeq NM_016568.3)
Gencode Transcript: ENST00000330120.5_4
Gencode Gene: ENSG00000182631.7_8
Transcript (Including UTRs)
Position: hg19 chr5:33,936,491-33,939,023 Size: 2,533 Total Exon Count: 1 Strand: +
Coding Region
Position: hg19 chr5:33,936,846-33,938,255 Size: 1,410 Coding Exon Count: 1
Data last updated at UCSC: 2024-08-22 23:36:26
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: RL3R1_HUMAN
DESCRIPTION: RecName: Full=Relaxin-3 receptor 1; Short=RLN3 receptor 1; AltName: Full=G protein-coupled receptor SALPR; AltName: Full=G-protein coupled receptor GPCR135; AltName: Full=Relaxin family peptide receptor 3; AltName: Full=Somatostatin- and angiotensin-like peptide receptor;
FUNCTION: Receptor for RNL3/relaxin-3. Binding of the ligand inhibit cAMP accumulation.SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.TISSUE SPECIFICITY: Expressed predominantly in brain regions. Highest expression in substantia nigra and pituitary, followed by hippocampus, spinal cord, amygdala, caudate nucleus and corpus callosum, quite low level in cerebellum. In peripheral tissues, relatively high levels in adrenal glands, low levels in pancreas, salivary gland, placenta, mammary gland and testis.SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
Primer design for this transcript
Comparative Toxicogenomics Database (CTD)
The following chemicals interact with this gene
Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR000276 - 7TM_GPCR_Rhodpsn
IPR000826 - Frt_met_rcpt
IPR017452 - GPCR_Rhodpsn_supfam
Pfam Domains: PF00001 - 7 transmembrane receptor (rhodopsin family)
SCOP Domains: 81321 - Family A G protein-coupled receptor-like
ModBase Predicted Comparative 3D Structure on Q9NSD7
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0004871 signal transducer activity
GO:0004930 G-protein coupled receptor activity
GO:0004966 galanin receptor activity
GO:0008528 G-protein coupled peptide receptor activity
Biological Process: GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007218 neuropeptide signaling pathway
GO:0032467 positive regulation of cytokinesis
GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
Cellular Component: GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Descriptions from all associated GenBank mRNAs
D88437 - Homo sapiens mRNA for G-protein coupled receptor SALPR, complete cds.JD169908 - Sequence 150932 from Patent EP1572962.JD408630 - Sequence 389654 from Patent EP1572962.JD534909 - Sequence 515933 from Patent EP1572962.JD534910 - Sequence 515934 from Patent EP1572962.JD128499 - Sequence 109523 from Patent EP1572962.BC113438 - Homo sapiens relaxin/insulin-like family peptide receptor 3, mRNA (cDNA clone MGC:141998 IMAGE:8322490), complete cds.BC113440 - Homo sapiens relaxin/insulin-like family peptide receptor 3, mRNA (cDNA clone MGC:142000 IMAGE:8322492), complete cds.BC095526 - Homo sapiens relaxin/insulin-like family peptide receptor 3, mRNA (cDNA clone MGC:111744 IMAGE:30706560), complete cds.JD295928 - Sequence 276952 from Patent EP1572962.HQ258443 - Synthetic construct Homo sapiens clone IMAGE:100072872 relaxin/insulin-like family peptide receptor 3 (RXFP3) gene, encodes complete protein.EU831899 - Synthetic construct Homo sapiens clone HAIB:100066928; DKFZo004G0622 relaxin/insulin-like family peptide receptor 3 protein (RXFP3) gene, encodes complete protein.EU831822 - Synthetic construct Homo sapiens clone HAIB:100066851; DKFZo008G0621 relaxin/insulin-like family peptide receptor 3 protein (RXFP3) gene, encodes complete protein.AY394501 - Homo sapiens relaxin-3 receptor-1 mRNA, complete cds.JD419399 - Sequence 400423 from Patent EP1572962.
Biochemical and Signaling Pathways
Other Names for This Gene
Alternate Gene Symbols: ENST00000330120.1, ENST00000330120.2, ENST00000330120.3, ENST00000330120.4, GPCR135, NM_016568, Q14DA5, Q9NSD7, RL3R1_HUMAN, RLN3R1, SALPR, uc317sws.1, uc317sws.2UCSC ID: ENST00000330120.5_4RefSeq Accession: NM_016568.3
Protein: Q9NSD7
(aka RL3R1_HUMAN)
Gene Model Information
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Methods, Credits, and Use Restrictions
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