Human Gene RYBP (ENST00000477973.5_14) from GENCODE V47lift37
Description: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1-like complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:25519132). Component of a PRC1-like complex that mediates monoubiquitination of histone H2A 'Lys-119' on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females. May stimulate ubiquitination of histone H2A 'Lys-119' by recruiting the complex to target sites (By similarity). Inhibits ubiquitination and subsequent degradation of TP53, and thereby plays a role in regulating transcription of TP53 target genes (PubMed:19098711). May also regulate the ubiquitin-mediated proteasomal degradation of other proteins like FANK1 to regulate apoptosis (PubMed:14765135, PubMed:27060496). May be implicated in the regulation of the transcription as a repressor of the transcriptional activity of E4TF1 (PubMed:11953439). May bind to DNA (By similarity). May play a role in the repression of tumor growth and metastasis in breast cancer by down-regulating SRRM3 (PubMed:27748911). (from UniProt Q8N488) Gencode Transcript: ENST00000477973.5_14 Gencode Gene: ENSG00000163602.12_15 Transcript (Including UTRs) Position: hg19 chr3:72,420,976-72,495,772 Size: 74,797 Total Exon Count: 4 Strand: - Coding Region Position: hg19 chr3:72,427,536-72,495,772 Size: 68,237 Coding Exon Count: 4
ID:RYBP_HUMAN DESCRIPTION: RecName: Full=RING1 and YY1-binding protein; AltName: Full=Apoptin-associating protein 1; Short=APAP-1; AltName: Full=Death effector domain-associated factor; Short=DED-associated factor; AltName: Full=YY1 and E4TF1-associated factor 1; FUNCTION: Inhibits ubiquitination and subsequent degradation of TP53, and thereby plays a role in regulating transcription of TP53 target genes. May be implicated in the regulation of the transcription as a repressor of the transcriptional activity of E4TF1. May bind to DNA. Promotes apoptosis. SUBUNIT: Monomer. Interacts with apoptin, DEDD, FADD, CASP8, CASP10, YY1 and GABPB1. Component of repressive BCOR complex containing Polycomb group subcomplex at least composed of BCOR, PCGF1, RING1 and RNF2/RING2. Together with GABPB1 and YY1, it forms a ternary complex, probably being the bridge factor between these two transcription factors. Interacts with CBX2, YAF2, RING1 and RNF2. Interacts with ubiquitin and ubiquitinated proteins. Interacts with ubiquitinated histone H2A (By similarity). Interacts with MDM2, and thereby inhibits ubiquitination of TP53. Identified in a ternary complex containing MDM2, TP53 and RYBP. INTERACTION: Q06587:RING1; NbExp=2; IntAct=EBI-752324, EBI-752313; SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Nucleus, nucleoplasm (By similarity). Note=Primarily found in the nucleus. Detected in a punctate pattern likely to represent Polycomb group (PcG) bodies (By similarity). TISSUE SPECIFICITY: Widely expressed with highest levels in lymphoid tissues and placenta. DOMAIN: Intrinsically unstructured in the absence of binding partners. Folds upon binding to DNA or RNF2 (By similarity). PTM: Monoubiquitinated (By similarity). SIMILARITY: Contains 1 RanBP2-type zinc finger. SEQUENCE CAUTION: Sequence=AAK63197.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAO73587.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAA89486.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8N488
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse
Rat
Zebrafish
D. melanogaster
C. elegans
S. cerevisiae
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
Gene Ontology (GO) Annotations with Structured Vocabulary
Biological Process: GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006915 apoptotic process GO:0007275 multicellular organism development GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0035518 histone H2A monoubiquitination GO:0043065 positive regulation of apoptotic process GO:0045893 positive regulation of transcription, DNA-templated GO:0070317 negative regulation of G0 to G1 transition
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
