Human Gene S100A10 (ENST00000368811.8_7) from GENCODE V47lift37
  Description: S100 calcium binding protein A10 (from RefSeq NM_002966.3)
Gencode Transcript: ENST00000368811.8_7
Gencode Gene: ENSG00000197747.9_9
Transcript (Including UTRs)
   Position: hg19 chr1:151,955,391-151,966,335 Size: 10,945 Total Exon Count: 3 Strand: -
Coding Region
   Position: hg19 chr1:151,955,639-151,958,706 Size: 3,068 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:151,955,391-151,966,335)mRNA (may differ from genome)Protein (97 aa)
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-  Comments and Description Text from UniProtKB
  ID: S10AA_HUMAN
DESCRIPTION: RecName: Full=Protein S100-A10; AltName: Full=Calpactin I light chain; AltName: Full=Calpactin-1 light chain; AltName: Full=Cellular ligand of annexin II; AltName: Full=S100 calcium-binding protein A10; AltName: Full=p10 protein; AltName: Full=p11;
FUNCTION: Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine- specific kinase.
SUBUNIT: Heterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of ANXA2/p36. Interacts with SCN10A (By similarity).
MISCELLANEOUS: Does not appear to bind calcium. Contains 2 ancestral calcium site related to EF-hand domains that have lost their ability to bind calcium.
SIMILARITY: Belongs to the S-100 family.
WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/S100A10ID44145ch1q21.html";

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: S100A10
Diseases sorted by gene-association score: hemophagocytic lymphohistiocytosis, familial, 3 (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 443.14 RPKM in Esophagus - Mucosa
Total median expression: 4192.12 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -32.40129-0.251 Picture PostScript Text
3' UTR -43.50248-0.175 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011992 - EF-hand-like_dom
IPR001751 - S100/CaBP-9k_CS
IPR013787 - S100_Ca-bd_sub

Pfam Domains:
PF01023 - S-100/ICaBP type calcium binding domain

SCOP Domains:
47473 - EF-hand

Protein Data Bank (PDB) 3-D Structure
MuPIT help
1A4P - X-ray MuPIT 1BT6 - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on P60903
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0042803 protein homodimerization activity
GO:0044325 ion channel binding
GO:0008289 lipid binding

Biological Process:
GO:0001765 membrane raft assembly
GO:0006900 membrane budding
GO:0042493 response to drug
GO:0043547 positive regulation of GTPase activity
GO:0051099 positive regulation of binding
GO:0051290 protein heterotetramerization
GO:0051496 positive regulation of stress fiber assembly
GO:0051894 positive regulation of focal adhesion assembly
GO:0072659 protein localization to plasma membrane
GO:1900026 positive regulation of substrate adhesion-dependent cell spreading

Cellular Component:
GO:0005576 extracellular region
GO:0005783 endoplasmic reticulum
GO:0019897 extrinsic component of plasma membrane
GO:0070062 extracellular exosome
GO:0045121 membrane raft


-  Descriptions from all associated GenBank mRNAs
  LF206217 - JP 2014500723-A/13720: Polycomb-Associated Non-Coding RNAs.
BC105786 - Homo sapiens S100 calcium binding protein A10, mRNA (cDNA clone MGC:111133 IMAGE:6701084), complete cds.
BC015973 - Homo sapiens S100 calcium binding protein A10, mRNA (cDNA clone MGC:23737 IMAGE:4103596), complete cds.
M81457 - Human calpactin 1 light chain mRNA, complete cds.
M38591 - Homo sapiens cellular ligand of annexin II (p11) mRNA, complete cds.
AK291073 - Homo sapiens cDNA FLJ77627 complete cds, highly similar to Homo sapiens S100 calcium binding protein A10 (annexin II ligand, calpactin I, light polypeptide (p11)) (S100A10), mRNA.
JD281190 - Sequence 262214 from Patent EP1572962.
JD239533 - Sequence 220557 from Patent EP1572962.
LF352442 - JP 2014500723-A/159945: Polycomb-Associated Non-Coding RNAs.
LF352441 - JP 2014500723-A/159944: Polycomb-Associated Non-Coding RNAs.
DQ893555 - Synthetic construct clone IMAGE:100006185; FLH195068.01X; RZPDo839F0483D S100 calcium binding protein A10 (annexin II ligand, calpactin I, light polypeptide (p11)) (S100A10) gene, encodes complete protein.
DQ893556 - Synthetic construct clone IMAGE:100006186; FLH195069.01X; RZPDo839G0483D S100 calcium binding protein A10 (annexin II ligand, calpactin I, light polypeptide (p11)) (S100A10) gene, encodes complete protein.
DQ893557 - Synthetic construct clone IMAGE:100006187; FLH195070.01X; RZPDo839H0483D S100 calcium binding protein A10 (annexin II ligand, calpactin I, light polypeptide (p11)) (S100A10) gene, encodes complete protein.
KJ897512 - Synthetic construct Homo sapiens clone ccsbBroadEn_06906 S100A10 gene, encodes complete protein.
DQ896803 - Synthetic construct Homo sapiens clone IMAGE:100011263; FLH195064.01L; RZPDo839B0483D S100 calcium binding protein A10 (annexin II ligand, calpactin I, light polypeptide (p11)) (S100A10) gene, encodes complete protein.
DQ896804 - Synthetic construct Homo sapiens clone IMAGE:100011264; FLH195066.01L; RZPDo839D0483D S100 calcium binding protein A10 (annexin II ligand, calpactin I, light polypeptide (p11)) (S100A10) gene, encodes complete protein.
AB464694 - Synthetic construct DNA, clone: pF1KB8860, Homo sapiens S100A10 gene for S100 calcium binding protein A10, without stop codon, in Flexi system.
CR542162 - Homo sapiens full open reading frame cDNA clone RZPDo834A0524D for gene S100A10, S100 calcium binding protein A10 (annexin II ligand, calpactin I, light polypeptide (p11)); complete cds, without stopcodon.
LF352440 - JP 2014500723-A/159943: Polycomb-Associated Non-Coding RNAs.
LF352439 - JP 2014500723-A/159942: Polycomb-Associated Non-Coding RNAs.
LF352438 - JP 2014500723-A/159941: Polycomb-Associated Non-Coding RNAs.
D28387 - Homo sapiens mRNA for calpactin I light chain, 5'UTR region.
MA588019 - JP 2018138019-A/159945: Polycomb-Associated Non-Coding RNAs.
MA588018 - JP 2018138019-A/159944: Polycomb-Associated Non-Coding RNAs.
MA588017 - JP 2018138019-A/159943: Polycomb-Associated Non-Coding RNAs.
MA588016 - JP 2018138019-A/159942: Polycomb-Associated Non-Coding RNAs.
MA588015 - JP 2018138019-A/159941: Polycomb-Associated Non-Coding RNAs.
MA441794 - JP 2018138019-A/13720: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: A8K4V8, ANX2LG, CAL1L, CLP11, ENST00000368811.1, ENST00000368811.2, ENST00000368811.3, ENST00000368811.4, ENST00000368811.5, ENST00000368811.6, ENST00000368811.7, NM_002966, P08206, P60903, Q5T1C5, S10AA_HUMAN, uc318hbu.1, uc318hbu.2
UCSC ID: ENST00000368811.8_7
RefSeq Accession: NM_002966.3
Protein: P60903 (aka S10AA_HUMAN or S110_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.