Human Gene S100A14 (ENST00000344616.4_8) from GENCODE V47lift37
  Description: S100 calcium binding protein A14 (from RefSeq NM_020672.3)
Gencode Transcript: ENST00000344616.4_8
Gencode Gene: ENSG00000189334.9_10
Transcript (Including UTRs)
   Position: hg19 chr1:153,586,731-153,588,801 Size: 2,071 Total Exon Count: 4 Strand: -
Coding Region
   Position: hg19 chr1:153,587,361-153,588,334 Size: 974 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:153,586,731-153,588,801)mRNA (may differ from genome)Protein (104 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedUniProtKBWikipedia
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: S10AE_HUMAN
DESCRIPTION: RecName: Full=Protein S100-A14; AltName: Full=S100 calcium-binding protein A14; Short=S114;
SUBCELLULAR LOCATION: Cytoplasm.
TISSUE SPECIFICITY: Expressed at highest levels in colon and at moderate levels in thymus, kidney, liver, small intestine, and lung. Low expression in heart and no expression is seen in brain, skeletal muscle, spleen, placenta and peripheral blood leukocytes.
SIMILARITY: Belongs to the S-100 family.
SIMILARITY: Contains 2 EF-hand domains.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 1573.69 RPKM in Esophagus - Mucosa
Total median expression: 3231.45 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -28.00109-0.257 Picture PostScript Text
3' UTR -231.90630-0.368 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011992 - EF-hand-like_dom
IPR013787 - S100_Ca-bd_sub

Pfam Domains:
PF01023 - S-100/ICaBP type calcium binding domain

SCOP Domains:
47473 - EF-hand

ModBase Predicted Comparative 3D Structure on Q9HCY8
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0042379 chemokine receptor binding

Biological Process:
GO:0006915 apoptotic process
GO:0032496 response to lipopolysaccharide
GO:0034142 toll-like receptor 4 signaling pathway
GO:0042742 defense response to bacterium
GO:0055074 calcium ion homeostasis
GO:0071624 positive regulation of granulocyte chemotaxis
GO:0090026 positive regulation of monocyte chemotaxis

Cellular Component:
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016604 nuclear body
GO:0030054 cell junction
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular exosome


-  Descriptions from all associated GenBank mRNAs
  AY007220 - Homo sapiens S100-type calcium binding protein A14 mRNA, complete cds.
JD437958 - Sequence 418982 from Patent EP1572962.
JD498632 - Sequence 479656 from Patent EP1572962.
JD264077 - Sequence 245101 from Patent EP1572962.
JD205189 - Sequence 186213 from Patent EP1572962.
JD536688 - Sequence 517712 from Patent EP1572962.
JD418980 - Sequence 400004 from Patent EP1572962.
JD467171 - Sequence 448195 from Patent EP1572962.
JD360499 - Sequence 341523 from Patent EP1572962.
JD303800 - Sequence 284824 from Patent EP1572962.
JD485321 - Sequence 466345 from Patent EP1572962.
JD304225 - Sequence 285249 from Patent EP1572962.
JD132427 - Sequence 113451 from Patent EP1572962.
BC005019 - Homo sapiens S100 calcium binding protein A14, mRNA (cDNA clone MGC:11012 IMAGE:3640899), complete cds.
HQ447959 - Synthetic construct Homo sapiens clone IMAGE:100071321; CCSB004325_02 S100 calcium binding protein A14 (S100A14) gene, encodes complete protein.
KJ894421 - Synthetic construct Homo sapiens clone ccsbBroadEn_03815 S100A14 gene, encodes complete protein.
JD249426 - Sequence 230450 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000344616.1, ENST00000344616.2, ENST00000344616.3, NM_020672, Q5RHT0, Q9HCY8, S100A15, S10AE_HUMAN, uc317wzs.1, uc317wzs.2
UCSC ID: ENST00000344616.4_8
RefSeq Accession: NM_020672.3
Protein: Q9HCY8 (aka S10AE_HUMAN or S114_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.