Human Gene S100A7 (ENST00000368723.4_7) from GENCODE V47lift37
  Description: S100 calcium binding protein A7 (from RefSeq NM_002963.4)
Gencode Transcript: ENST00000368723.4_7
Gencode Gene: ENSG00000143556.9_9
Transcript (Including UTRs)
   Position: hg19 chr1:153,430,220-153,433,127 Size: 2,908 Total Exon Count: 3 Strand: -
Coding Region
   Position: hg19 chr1:153,430,282-153,431,489 Size: 1,208 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:153,430,220-153,433,127)mRNA (may differ from genome)Protein (101 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MalacardsMGIOMIMPubMedReactomeUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: S10A7_HUMAN
DESCRIPTION: RecName: Full=Protein S100-A7; AltName: Full=Psoriasin; AltName: Full=S100 calcium-binding protein A7;
SUBUNIT: Interacts with RANBP9.
INTERACTION: Q96S59:RANBP9; NbExp=3; IntAct=EBI-357520, EBI-636085;
SUBCELLULAR LOCATION: Cytoplasm. Secreted. Note=Secreted by a non- classical secretory pathway.
TISSUE SPECIFICITY: Fetal ear, skin, and tongue and human cell lines. Highly up-regulated in psoriatic epidermis. Also highly expressed in the urine of bladder squamous cell carcinoma (SCC) bearing patients.
MASS SPECTROMETRY: Mass=11365; Mass_error=0.7; Method=Electrospray; Range=2-101; Source=PubMed:8526920;
SIMILARITY: Belongs to the S-101 family.
SIMILARITY: Contains 2 EF-hand domains.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: S100A7
Diseases sorted by gene-association score: bladder squamous cell carcinoma (26), psoriasis (8), squamous cell carcinoma (5), ductal carcinoma in situ (3), porokeratosis (3), lung squamous cell carcinoma (3), skin disease (3), trachea leiomyoma (2), pre-malignant neoplasm (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 29.46 RPKM in Skin - Not Sun Exposed (Suprapubic)
Total median expression: 101.71 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -5.6061-0.092 Picture PostScript Text
3' UTR -8.6062-0.139 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011992 - EF-hand-like_dom
IPR018247 - EF_Hand_1_Ca_BS
IPR018249 - EF_HAND_2
IPR001751 - S100/CaBP-9k_CS
IPR013787 - S100_Ca-bd_sub

Pfam Domains:
PF01023 - S-100/ICaBP type calcium binding domain

SCOP Domains:
47473 - EF-hand

Protein Data Bank (PDB) 3-D Structure
MuPIT help
1PSR - X-ray MuPIT 2PSR - X-ray MuPIT 2WND - X-ray MuPIT 2WOR - X-ray MuPIT 2WOS - X-ray MuPIT 3PSR - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on P31151
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
GO:0046914 transition metal ion binding
GO:0050786 RAGE receptor binding

Biological Process:
GO:0000302 response to reactive oxygen species
GO:0001525 angiogenesis
GO:0008544 epidermis development
GO:0010820 positive regulation of T cell chemotaxis
GO:0019730 antimicrobial humoral response
GO:0030216 keratinocyte differentiation
GO:0032496 response to lipopolysaccharide
GO:0043312 neutrophil degranulation
GO:0045087 innate immune response
GO:0050829 defense response to Gram-negative bacterium
GO:0051238 sequestering of metal ion
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071624 positive regulation of granulocyte chemotaxis
GO:0090026 positive regulation of monocyte chemotaxis

Cellular Component:
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0005925 focal adhesion
GO:0031012 extracellular matrix
GO:0035578 azurophil granule lumen


-  Descriptions from all associated GenBank mRNAs
  S81991 - psoriasin {3' region} [human, psoriatic skin lesion biopsy, psoriasis patient, mRNA Partial Mutant, 123 nt].
M86757 - Human psoriasin mRNA, complete cds.
BC034687 - Homo sapiens S100 calcium binding protein A7, mRNA (cDNA clone MGC:21353 IMAGE:4751685), complete cds.
JD549811 - Sequence 530835 from Patent EP1572962.
DQ891277 - Synthetic construct clone IMAGE:100003907; FLH170676.01X; RZPDo839A04100D S100 calcium binding protein A7 (psoriasin 1) (S100A7) gene, encodes complete protein.
DQ894465 - Synthetic construct Homo sapiens clone IMAGE:100008925; FLH170672.01L; RZPDo839A0499D S100 calcium binding protein A7 (psoriasin 1) (S100A7) gene, encodes complete protein.
CR542164 - Homo sapiens full open reading frame cDNA clone RZPDo834C0524D for gene S100A7, S100 calcium binding protein A7 (psoriasin 1); complete cds, incl. stopcodon.
KJ897511 - Synthetic construct Homo sapiens clone ccsbBroadEn_06905 S100A7 gene, encodes complete protein.
AB464699 - Synthetic construct DNA, clone: pF1KB8862, Homo sapiens S100A7 gene for S100 calcium binding protein A7, without stop codon, in Flexi system.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein P31151 (Reactome details) participates in the following event(s):

R-HSA-6798751 Exocytosis of azurophil granule lumen proteins
R-HSA-6798489 S100A7 or S100A7A binds Zn2+
R-HSA-6798695 Neutrophil degranulation
R-HSA-168249 Innate Immune System
R-HSA-6799990 Metal sequestration by antimicrobial proteins
R-HSA-168256 Immune System
R-HSA-6803157 Antimicrobial peptides

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000368723.1, ENST00000368723.2, ENST00000368723.3, NM_002963, P31151, PSOR1, Q5SY67, Q6FGE3, Q9H1E2, S100A7C, S10A7_HUMAN, uc318gzx.1, uc318gzx.2
UCSC ID: ENST00000368723.4_7
RefSeq Accession: NM_002963.4
Protein: P31151 (aka S10A7_HUMAN or S107_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.